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ψ 
ψ 

Spermidine

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Definition: A polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.     
Examples Spermine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1,8-diamino-3-methyl-4-azaoctane  0   Spermidine/*analogs & derivatives. Bioorg Khim. 2011 Mar-Apr;37(2):253-8
didemnidine B  0   *Indole Alkaloids Spermidine/*analogs & derivatives. J Nat Prod. 2011 Apr 25;74(4):888-92
didemnidine A  0   *Indole Alkaloids Spermidine/*analogs & derivatives. J Nat Prod. 2011 Apr 25;74(4):888-92
N1-(4,5-dihydro-3H-azepin-2-yl)spermidine  0   *Azepines Spermidine/*analogs & derivatives. J Med Chem 2010 Nov 11;53(21):7647-63
N1,N5-di(hydroxyferuloyl)-N10-sinapoylspermidine  0   Spermidine/*analogs & derivatives. Science. 2009 Sep 25;325(5948):1688-92
keayanine  0   *Coumaric Acids Spermidine/*analogs & derivatives Alkaloids. Phytother Res 2009 Jun;23(6):892-5
N-(3-(3-aminopropylamino)propyl)-2-oxo-2H-chromene-3-carboxamide  0   *Coumarins Spermidine/*analogs & derivatives. Int J Radiat Biol 2008 Dec;84(12):1001-10
keayanidine B  0   *Coumaric Acids Spermidine/*analogs & derivatives. Chem Biodivers 2006 Sep;3(9):982-9
anthracenylmethyl homospermidine  0   *Anthracenes Spermidine/*analogs & derivatives. Toxicol In Vitro 2008 Mar;22(2):352-8
N1,N8-bis(2,5-dihydroxybenzoyl)spermidine  0   Spermidine/*analogs & derivatives. Biochem Biophys Res Commun 2007 Jan 26;352(4):953-9
dovyalicin F  0   Spermidine/*analogs & derivatives. J Nat Prod 2006 Sep;69(9):1300-4
dovyalicin E  0   Spermidine/*analogs & derivatives. J Nat Prod 2006 Sep;69(9):1300-4
lunarine  0   Spermidine/*analogs & derivatives. Bioorg Med Chem 2006 Apr 1;14(7):2266-78
1-amino-8-acetamido-5-azanonane  0   Spermidine/*analogs & derivatives. J Biol Chem 2006 Feb 24;281(8):4589-95
N1,N10-ditigloylspermidine  0   Spermidine/*analogs & derivatives. Pharmazie 2005 Dec;60(12):958-9
N1,N8-bis(dihydrocaffeoyl)spermidine  0   Spermidine/*analogs & derivatives. J Agric Food Chem. 2005 Jun 29;53(13):5461-6
Spd-C2-BODIPY  0   *Boron Compounds Spermidine/*analogs & derivatives. J Biol Chem 2004 Nov 19;279(47):49355-66
L-arginyl-3,4-spermidine  0   Spermidine/*analogs & derivatives. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):216-24
N-(6-chloro-2-methoxyacridin-9-yl)spermidine  0   *Acridines Spermidine/*analogs & derivatives. Nucleic Acids Res 2003 Aug 1;31(15):4497-502
3-oxo-8,9b-bis(N(1)-acrylamidospermidyl)-1,2,3,4,4a,9b-hexahydroxanthene  0   *Xanthenes Spermidine/*analogs & derivatives. Biochem J 2003 Feb 1;369(Pt 3):529-37
spermidine-C2-BODIPY  0   *Boron Compounds Spermidine/*analogs & derivatives. Biochem J 2002 Oct 15;367(Pt 2):347-57
sulfonamido oxa-spermidine  0   *Sulfonamides Spermidine/*analogs & derivatives. Cell Mol Life Sci 2002 Apr;59(4):715-23
dioctadecylamidoglycylspermidine  0   Spermidine/*antagonists & inhibitors Liposomes. AAPS PharmSci. 2001;3(1):E7
N1,N5,N10-tris(4-coumaroyl)spermidine  0   *Coumaric Acids Spermidine/*analogs & derivatives. Chem Pharm Bull (Tokyo) 2001 Jul;49(7):915-7
bisnaphthalimidopropylspermidine  0   *Quinolones Spermidine/*analogs & derivatives. Chem Biol Interact 2001 Jul 31;137(1):15-24
N-(3-((4-aminobutyl)amino)propyl)((4-fluorophenyl)methyl)amine  0   Spermidine/*analogs & derivatives. J Med Chem 2001 Oct 25;44(22):3653-64
homofluviabactin  0   Spermidine/*analogs & derivatives. J Med Chem 2001 Jul 19;44(15):2469-78
N5,N6-thiodipropanoylbis(N1,N10-bis(2,3-dihydroxybenzoylspermidine))  0   *Catecholamines Spermidine/*analogs & derivatives. Bioorg Med Chem Lett 1999 Aug 16;9(16):2309-14
((4-(B-hydroxyboryl)phenyl)methyl)spermidine  0   *Boron Compounds Spermidine/*analogs & derivatives Boron Neutron Capture Therapy. J Med Chem 1999 Apr 8;42(7):1282-92
N(5)-(4-(2-aminoethyl-2-carboranyl)butyl)spermidine  0   *Boron Compounds Spermidine/*analogs & derivatives Boron Neutron Capture Therapy. J Med Chem 1999 Apr 8;42(7):1282-92
MS-681a  0   *Peptides Spermidine/*analogs & derivatives. J Antibiot (Tokyo) 1997 Dec;50(12):992-7
FR 160  0   Spermidine/*analogs & derivatives Siderophores. Antimicrob Agents Chemother 1997 Aug;41(8):1837-9
N-(N-methyl-N-(N,N-dimethylaminobutyl)aminopropyl)-5-methyltetradecen-3-enamide  0   *Fatty Acids, Monounsaturated Spermidine/*analogs & derivatives. J Nat Prod 1997 May;60(5):495-6
5-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-6-oxaspermidine  0   *Sulfonamides Spermidine/*analogs & derivatives Cytotoxins. Int J Biochem Cell Biol 1996 Jun;28(6):697-704
N(4)-(2-propenal)spermidine  0   Spermidine/*analogs & derivatives. Biol Pharm Bull 1995 Aug;18(8):1162-4
PotB protein, E coli  0   *ATP-Binding Cassette Transporters *Escherichia coli Proteins Spermidine. J Biol Chem 1995 Oct 27;270(43):25377-82
PotA protein, E coli  0   *ATP-Binding Cassette Transporters *Escherichia coli Proteins Spermidine Ca(2+) Mg(2+)-ATPase. J Biol Chem 1995 Oct 27;270(43):25377-82
adenosylspermidine  0   Adenosine/*analogs & derivatives Spermidine/*analogs & derivatives Spermidine Synthase/antagonists & inhibitors. J Med Chem 1995 Jul 7;38(14):2714-27
N(1),N(8)-diacetylspermidine  0   Spermidine/*analogs & derivatives. J Biochem (Tokyo) 1995 Jan;117(1):107-12
N-(2-aminooxyethyl)-1,4-diaminobutane  0   Spermidine/*analogs & derivatives Spermine Synthase/antagonists & inhibitors. Life Sci 1994 Dec 23;56(5):349-60
hispidospermidin  0   Spermidine/*analogs & derivatives Type C Phospholipases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Jan;47(1):6-15
N(8)-aziridinylspermidine  154264-47-8   *Aziridines Spermidine/*analogs & derivatives. Cancer Res 1994 Feb 1;54(3):742-8
N(1)-aziridinylspermidine  154264-46-7   *Aziridines Spermidine/*analogs & derivatives. Cancer Res 1994 Feb 1;54(3):742-8
N(1),N(7)-bis(2,3-dihydroxybenzoyl)norspermidine  88381-35-5   *Catechols Spermidine/*analogs & derivatives Siderophores. J Biochem (Tokyo) 1993 May;113(5):538-44
fluvibactin  103185-30-4 4-Oxazolecarboxamide, N,N-bis(3-((2,3-dihydroxybenzoyl)amino)propyl)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-5-methyl-, (4S-trans)  *Catechols Spermidine/*analogs & derivatives Siderophores. J Biochem (Tokyo) 1993 May;113(5):538-44
5,8-dimethylspermidine  149608-57-1   Spermidine/*analogs & derivatives Ornithine Decarboxylase/antagonists & inhibitors. Cancer Lett 1993 Apr 15;69(1):33-8
N-octamethylspermidine  132210-30-1   Spermidine/*analogs & derivatives. Biochemistry 1993 Jan 26;32(3):961-7
chlorambucil-spermidine conjugate  143984-22-9   Chlorambucil/*analogs & derivatives Spermidine/*analogs & derivatives. Cancer Res 1992 Aug 1;52(15):4190-5
1-methylspermidine  137946-02-2   Spermidine/*analogs & derivatives. J Med Chem 1992 Feb 21;35(4):724-34
N(4)-acetylspermidine  66039-56-3   Spermidine/*analogs & derivatives. Acta Chem Scand 1989;43(10):990
N(1)-benzyloxycarbonyl-N(8)-butoxycarbonylspermidine  68076-38-0   Spermidine/*analogs & derivatives. Acta Chem Scand 1989;43(10):990
hydroxynorspermidine  125144-89-0   Spermidine/*analogs & derivatives. Chem Pharm Bull 1989;37(11):3139
N(1)-acetylnorspermidine  70862-22-5   Spermidine/*analogs & derivatives. FEMS Microbiol Lett 1989;52(1-2):225
aminobutylhomospermidine  45185-87-3   Spermidine/*analogs & derivatives. Biochem Biophys Res Commun 1989;165(2):659
N(1),N(8)-bis(gamma-glutamyl)spermidine  74141-51-8   Spermidine/*analogs & derivatives. FEBS Lett 1989;245(1,2):150
spermexatol  117680-13-4   Spermidine/*analogs & derivatives. J Med Chem 1989;32(2):357
spermexatin  117680-04-3   Spermidine/*analogs & derivatives. J Med Chem 1989;32(2):357
N(1)-(gamma-glutamyl)spermidine  74141-50-7   Spermidine/*analogs & derivatives. Biochem J 1988;249(3):813
6,6-difluorospermidine  111397-40-1   Spermidine/*analogs & derivatives. Int J Biochem 1987;19(9):843
N(1),N(8)-diethylspermidine  97141-40-7   Spermidine/*analogs & derivatives. Cancer Res 1986;46(12 Pt 1):6279
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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