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Spermine

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Definition: A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
technetium 99m HYNIC-spermine  0   *Organotechnetium Compounds Spermine/*analogs & derivatives. Eur J Nucl Med Mol Imaging. 2011 Oct;38(10):1832-41.
kukoamine B  0   *Caffeic Acids Spermine/*analogs & derivatives. Int Immunopharmacol 2011 Jan;11(1):110-20
N1-(7-nitro-4,5-dihydro-3H-1-benzazepin-2-yl)spermine  0   *Benzazepines Spermine/*analogs & derivatives. J Med Chem 2010 Nov 11;53(21):7647-63
F 96982  0   *Oxadiazoles Spermine/*analogs & derivatives. Leuk Res 2010 Oct;34(10):1383-9
lysyl-epsilon-palmitoyl-N1-spermine  0   Lysine/*analogs & derivatives Spermine/*analogs & derivatives. J Med Chem 2009 Apr 9;52(7):1983-93
N1,N12-bis(2-oxo-2H-chromene-3-carbonyl)-1,12-diamine-4,9-diazadodecane  0   *Coumarins Spermine/*analogs & derivatives. Int J Radiat Biol 2008 Dec;84(12):1001-10
DS-96 compound  0   Spermine/*analogs & derivatives. J Pharm Sci 2008 Dec;97(12):5376-85
kearanine  0   *Coumaric Acids Spermine/*analogs & derivatives. Chem Pharm Bull (Tokyo) 2007 Apr;55(4):643-5
spermatinamine  0   Spermine/*analogs & derivatives Tyrosine/*analogs & derivatives. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6860-3
CGC 11102  0   Spermine/*analogs & derivatives. Amino Acids 2007 Aug;33(2):291-7
incasine C'  0   Spermine/*analogs & derivatives. J Asian Nat Prod Res 2007 Mar;9(2):115-8
carboxyspermine-cysteinyl-cholesterol  0   Cholesterol/*analogs & derivatives Spermine/*analogs & derivatives. J Control Release 2006 Dec 1;116(3):353-9
N1-cholesteryl spermine carbamate  0   *Carbamates Spermine/*analogs & derivatives. Pharm Res. 2006 Jul;23(7):1564-73
MQT 1426  0   Spermine/*analogs & derivatives. Int J Cancer 2006 May 1;118(9):2344-9
N4,N9-dioleoylspermine  0   Spermine/*analogs & derivatives. Pharm Res 2005 Jun;22(6):972-80
bisnaphthalimidopropyl spermine  0   *Quinolones Spermine/*analogs & derivatives. Int J Parasitol 2005 May;35(6):637-46
1,12-diamino-3,6,9-triazadodecane  0   Spermine/*analogs & derivatives. Bioorg Khim. 2005 May-Jun;31(3):303-11
1,12-diamino-4,9-diaza-5-oxadodecan  0   Spermine/*analogs & derivatives. Bioorg Khim. 2005 Mar-Apr;31(2):206-12
alpha-methylspermine  0   Spermine/*analogs & derivatives. Bioorg Khim. 2005 Mar-Apr;31(2):200-5
N(1)-(4-carboxy)benzoylspermine  0   Spermine/*analogs & derivatives. J Med Chem 2005 Jun 16;48(12):4120-37
N(1)-heptadecanoyl-1,16-diamino-4,8,13-triazahexadecane  0   *Amides Spermine/*analogs & derivatives. J Med Chem 2005 Apr 7;48(7):2589-99
11-(aminooxy)-4,9-diaza-1-aminoundecane  0   Spermine/*analogs & derivatives. Nucleic Acids Res 2004;32(2):579-89
1-(12-amino-4,9-diazadodecyl)-2-methyl-3-hydroxy-4(1H)-pyridinone  0   *Pyridones Spermine/*analogs & derivatives. J Med Chem 2003 Dec 4;46(25):5478-83
N1-(2-(1-((3-aminopropyl)amino)-4-(di-(3-aminopropyl)amino)butylcarboxamido)ethyl)-3,4-di-(oleyloxy)benzamide  0   *Benzamides Spermine/*analogs & derivatives. J Med Chem 2002 Nov 7;45(23):5023-9
1,14-bis(1-hydroxy-2-pyridon-6-oyl)-5,10-bis(3-hydroxy-1-methyl-2-pyridon-4-oyl)-1,5,10,14-tetraazatetradecane  0   *Pyridones Spermine/*analogs & derivatives Ligands. J Med Chem 2002 Aug 29;45(18):3963-71
sulfonamido oxa-spermine  0   *Sulfonamides Spermine/*analogs & derivatives. Cell Mol Life Sci 2002 Apr;59(4):715-23
3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate  0   *Cholestanes Spermine/*analogs & derivatives. Int J Obes Relat Metab Disord 2001 May;25(5):689-97
N(1)-spermine-lysinylamide  0   Lysine/*analogs & derivatives Spermine/*analogs & derivatives. J Med Chem 2001 Oct 25;44(22):3632-44
N-(3-((4-aminobutyl)amino)propyl)((4-(dihydroxyboryl)phenyl)methyl)amine  0   *Boron Compounds Spermine/*analogs & derivatives. J Med Chem 2001 Oct 25;44(22):3653-64
GalSper  0   *Monosaccharides Spermine/*analogs & derivatives. Bioconjug Chem 2001 Jul-Aug;12(4):569-75
ORI 1202  0   Lysine/*analogs & derivatives Spermine/*analogs & derivatives. Exp Cell Res 2000 Nov 25;261(1):293-302
(N(1),N(12))bis(ethyl)-6,7-dehydrospermine  0   Spermine/*analogs & derivatives. Antimicrob Agents Chemother 2000 Oct;44(10):2891-4
N(1)-(n-octanesulfonyl)spermine  0   *Sulfonamides Spermine/*analogs & derivatives. Mol Pharmacol 1997 May;51(5):861-71
N(1)-dansylspermine  0   *Dansyl Compounds Spermine/*analogs & derivatives. Mol Pharmacol 1997 May;51(5):861-71
6-hydroxy-3-(N(1)-sperminyl)-5alpha-cholan-24-oic acid  0   Cholic Acids Spermine/analogs & derivatives. Steroids 1996 Oct;61(10):565-71
N-(2,2'-dithio(ethyl,1'-aminoethyl))spermine 5-carboxamide  0   Cysteamine/*analogs & derivatives Spermine/*analogs & derivatives. J Biol Chem 1996 Nov 1;271(44):27556-63
N-(2-mercaptoethyl)spermine 5-carboxamide  0   *Sulfhydryl Compounds Spermine/*analogs & derivatives. J Biol Chem 1996 Nov 1;271(44):27556-63
2,2'-dithiobis(N-ethylspermine-5-carboxamide)  0   *Disulfides Spermine/*analogs & derivatives. J Biol Chem 1996 Nov 1;271(44):27556-63
N(1)N(14)-diethyl-3,12-dihydroxyhomospermine  0   Spermine/*analogs & derivatives. J Med Chem 1996 Jun 21;39(13):2461-71
6,9-dioxa-5,10-di-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)spermine  0   *Chromans Spermine/*analogs & derivatives Cytotoxins. Int J Biochem Cell Biol 1996 Jun;28(6):697-704
2,3-dioleyloxy-N-(2-(sperminecarboxamido)ethyl)-N,N-dimethyl-1-propanaminium trifluoroacetate  0   Spermine/*analogs & derivatives Lipids. Biotechniques 1995 Nov;19(5):816-23
1,12-diaziridinyl-4,9-diazadodecane  0   *Aziridines Spermine/*analogs & derivatives. J Med Chem 1996 Jan 5;39(1):339-41
kukoamine A  0   Spermine/*analogs & derivatives. Biochem J 1995 Oct 15;311(Pt 2):371-5
azidophenylspermine  0   *Azides Spermine/*analogs & derivatives. Eur J Pharmacol 1995 May 26;289(3):471-7
anthracene-9-carbonyl-N(1)-spermine  0   Spermine/*analogs & derivatives. Biopolymers 1994 Dec;34(12):1583-93
spermine nitric oxide complex  136587-13-8   Spermine/*analogs & derivatives.
Pharma Action Nitric Oxide Donors 		Chem Res Toxicol 1994 Sep-Oct;7(5):628-32
BE 4-4-4-4  147510-59-6   Spermine/*analogs & derivatives. Cancer Res 1993 Sep 1;53(17):3948-55
1,12-dimethylspermine  137946-03-3   Spermine/*analogs & derivatives. J Med Chem 1992 Feb 21;35(4):724-34
(5-azido-2-nitrobenzoyl)spermine  138109-67-8   *Azides Spermine/*analogs & derivatives. Nucleic Acids Res 1991;19(13):3701
N(1)-(azidobenzamidino)spermine  133009-20-8   *Azides Spermine/*analogs & derivatives. Biochemistry 1991;30(16):4009
1-naphthylacetylspermine  122306-11-0   Spermine/*analogs & derivatives. Brain Res 1990;524(2):282
spermine-platinum complex  0   *Organoplatinum Compounds *Spermine. J Inorg Biochem 1990;40(1):13
Het 389 toxin  0   *Indoles Spermine/*analogs & derivatives Neurotoxins Spider Venoms. Toxicon 1990;28(5):541
dioctadecylamidospermine  133294-12-9   Spermine/*analogs & derivatives. J Neurochem 1990;54(5):1812
methidiumspermine sepharose  123757-91-5   Sepharose/*analogs & derivatives Spermine/*analogs & derivatives. Nucleic Acids Res 1989;17(17):6947
1,2-dipalmitoylphosphatidylethanolamidospermine  124076-29-5   *Phosphatidylethanolamines Spermine/*analogs & derivatives. Proc Natl Acad Sci USA 1989;86(18):6982
dioctadecylamidoglycylspermine  124050-77-7   Glycine/*analogs & derivatives Spermine/*analogs & derivatives Transfection. Proc Natl Acad Sci USA 1989;86(18):6982
N(1),N(11)-diethylnorspermine  121749-39-1   Spermine/*analogs & derivatives.
Pharma Action Antihypertensive Agents ; Antineoplastic Agents 		Cancer Res 1989;49(11):2959
MDL 26752  25712-59-8   Spermine/*analogs & derivatives. Biochem J 1989;257(3):769
N(1),N(14)-bis(ethyl)homospermine  119422-08-1   Spermine/*analogs & derivatives.
Pharma Action Antihypertensive Agents ; Antineoplastic Agents ; Radiation-Sensitizing Agents 		Cancer Res 1989;49(3):639
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