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Sphingolipids

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Definition: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)     
See Also Sphingosine
Examples Glycosphingolipids 		Other names Lysosphingolipids
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
K6EAA-L12  0   *Sphingolipids. Exp Dermatol 2011 Apr;20(4):314-9
mucusoside  0   *Sphingolipids. Chem Pharm Bull (Tokyo). 2010;58(12):1661-5
mucusamide  0   *Sphingolipids. Chem Pharm Bull (Tokyo). 2010;58(12):1661-5
2N-(tetradecanoyl)-4(E),8(E)-icosadiene-1,3-diol  0   *Sphingolipids. Chem Pharm Bull (Tokyo). 2010;58(12):1635-8
leucettamol A  0   *Sphingolipids. Bioorg Med Chem Lett 2008 Dec 15;18(24):6319-20
1-O-beta-D-glucopyranosyl-(2S,2'R,3R,3'E,4E,8E)-N-(2'-hydroxy-3'-hexadecenoyl)-9-methyl-4,8-icosadien-1,3-diol  0   *Sphingolipids. Lipids 2007 Aug;42(8):759-64
N-acetylphytosphingosine  0   *Sphingolipids Apoptosis. Apoptosis. 2006 Apr;11(4):581-8
2-amino-14,16-dimethyloctadecan-3-ol  0   *Sphingolipids. Toxicon 2005 Oct;46(5):513-22
glucosyloctanoylsphingosine  0   *Sphingolipids. Methods Enzymol 2000;311:42-9
1,3,4-triacetoxy-2-(2'-acetoxyoctadecanoyl)aminooctadecane  0   *Sphingolipids. Chem Pharm Bull (Tokyo) 1999 Sep;47(9):1214-20
1,3,4-trihydroxy-2-(2'-hydroxytetradecanoyl)aminotricosane  0   *Sphingolipids. Chem Pharm Bull (Tokyo) 1999 Sep;47(9):1214-20
1-phenyl-2-palmitoylamino-3-morpholino-1-propanol  0   *Morpholines *Sphingolipids. Proc Natl Acad Sci U S A 1995 Sep 26;92(20):9181-5
globotriaosyl lysosphingolipid  126550-86-5   *Glycolipids *Sphingolipids. Biochem J 1990;266(1):25

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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