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Sphingomyelin Phosphodiesterase

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Definition: An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.  /defic: consider also NIEMANN-PICK DISEASE   
See Also Niemann-Pick Diseases 		Other names Sphingomyelinase C; Sphingomyelinase; Sphingomyelin Cleaving Enzyme; Sphingomyelin Cholinephosphohydrolase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RY221B-a  0   Sphingosine/*analogs & derivatives 2,2'-Dipyridyl/*analogs & derivatives Sphingomyelin Phosphodiesterase/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Jul 1;20(13):3868-71
neutral sphingomyelinase 3, human  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase. Biochim Biophys Acta. 2009 Nov-Dec;1789(11-12):681-90
sphingomyelin phosphodiesterase 1, human  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase. J Obstet Gynaecol Res. 2009 Jun;35(3):421-8
neutral sphingomyelinase-1, human  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase. J Biol Chem 2000 Sep 8;275(36):28316-25
intestinal alkaline sphingomyelinase, human  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase. Biochim Biophys Acta 2005 Feb 21;1687(1-3):94-102
intestinal alkaline sphingomyelinase, rat  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase. Biochim Biophys Acta 2005 Feb 21;1687(1-3):94-102
SMPDL3B protein, human  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase. Blood. 2006 Feb 1;107(3):1070-7
sphingomyelinase I, Loxosceles laeta  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase *Spider Venoms. Acta Crystallogr D Biol Crystallogr 2004 Jun;60(Pt 6):1112-4
SMPD3 protein, human  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase.
Smpd3 protein, mouse  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase.
SMPDL3A protein, human  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase Tumor Markers, Biological. J Urol 2002 Dec;168960:2645-9
TK4 sphingomyelinase  EC 3.1.4.-   *Sphingomyelin Phosphodiesterase Hemolysin Proteins. J Bacteriol 2002 Jan;184(2):540-6
scyphostatin  0   *Amides *Pyrones Sphingomyelin Phosphodiesterase/antagonists & inhibitors. J Antibiot (Tokyo) 1999 Jun;52(6):525-30
acid sphingomyelinase-2  EC 3.1.4.-   *Sphingomyelin Phosphodiesterase. J Biol Chem 1998 Jun 5;273(23):14374-9
acid sphingomyelinase-1  EC 3.1.4.-   *Sphingomyelin Phosphodiesterase. J Biol Chem 1998 Jun 5;273(23):14374-9
Smpd3 protein, rat  EC 3.1.4.12   *Sphingomyelin Phosphodiesterase. J Biol Chem 1997 Jul 18;272(29):18082-6
altenusin  31186-12-6   *Biphenyl Compounds Myosin-Light-Chain Kinase/antagonists & inhibitors Sphingomyelin Phosphodiesterase/antagonists & inhibitors. Biosci Biotech Biochem 1995 Jul;59(7):1333-5
fantofarone  114432-13-2 Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-(3-(4-((2-(1-methylethyl)-1-indolizinyl)sulfonyl)phenoxy)propyl)  *Indolizines *Phenethylamines Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Pharma Action Calcium Channel Blockers ; Enzyme Inhibitors ; Vasodilator Agents 		Naunyn Schmiedebergs Arch Pharmacol 1989;339(1-2):31
tricyclodecane-9-yl-xanthogenate  83373-60-8   *Bridged Compounds *Thiones Type C Phospholipases/antagonists & inhibitors Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Antioxidants ; Antiviral Agents ; Phosphodiesterase Inhibitors 		J Gen Virol 1985;66(Pt 9):1953
hlb protein, Staphylococcus aureus  EC 3.1.4.12   *Bacterial Toxins *Hemolysin Proteins *Sphingomyelin Phosphodiesterase. Acta Pathol Microbiol Immunol Scand 1983;91(5):351; Infect Immun 1981;31(3):952

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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