encyclopedia of medical concepts
ψ 
ψ 

Spiro Compounds

More information in Books or onNLM PubMed
Definition: A group of compounds consisting in part of two rings sharing one carbon atom in common.  DF: SPIRO CPDS   
Examples Buspirone; Fluorescamine; Fluoresceins; Fluspirilene; Leucogenenol; Prospidium; Spiperone 		Other names Compounds, Spiro
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-(1,2,6,7-tetraoxaspiro(7.11)nonadec-4-yl)hexan-1-ol  0   *Hexanols *Spiro Compounds Antimalarials. Parasitol Int. 2011 Sep;60(3):270-3
maistemonine  0   *Azepines *Spiro Compounds Alkaloids. J Org Chem. 2011 Dec 16;76(24):10173-86
cycloelatanene B  0   *Furans *Spiro Compounds. Phytochemistry. 2011 Nov;72(16):2081-9
cycloelatanene A  0   *Furans *Spiro Compounds. Phytochemistry. 2011 Nov;72(16):2081-9
tenuipyrone  0   *Pyrones *Spiro Compounds. Org Lett. 2012 Jan 20;14(2):513-5
portentol  0   *Pyrans *Spiro Compounds. Org Lett. 2012 Jan 6;14(1):58-61
2'-(tert-butyl)-1-(1H-indazole-5-carbonyl)-2'H-spiro(piperidine-4,5'-pyrano(3,2-c)pyrazol)-7'(6'H)-one  0   *Indazoles *Spiro Compounds Acetyl-CoA Carboxylase. J Med Chem. 2012 Jan 26;55(2):935-42.
spirotetramat  0   *Aza Compounds *Spiro Compounds Insecticides. Bull Environ Contam Toxicol. 2012 Feb;88(2):124-8
(2'R,3R,4R,4aS,7aR)-methyl-3-hydroxy-4'-((S)-1-hydroxyethyl)-5'-oxo-3,4,4a,7a-tetrahydro-1H,5'H-spiro(cyclopenta(c)pyran-7,2'-furan)-4-carboxylate  0   *Furans *Pyrans *Spiro Compounds. Acta Crystallogr C. 2011 Oct;67(Pt 10):o409-12
1-oxa-8-azaspiro(4.5)decane urea  0   *Aza Compounds *Spiro Compounds Urea/*analogs & derivatives. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53
PF-04862853  0   *Spiro Compounds Aza Compounds. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53
1-oxa-8-azaspiro(4.5)decane  0   *Aza Compounds *Spiro Compounds. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44
7-azaspiro(3.5)nonane  0   *Aza Compounds *Spiro Compounds. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44
1',3'-dihydrospiro(fluorene-9,2'-perimidine)  0   *Fluorenes *Spiro Compounds. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Nov;82(1):56-62
1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one  0   *Spiro Compounds *Thiadiazoles. J Biol Chem. 2011 Nov 4;286(44):38000-17.
pestalospirane B  0   *Benzoxepins *Spiro Compounds. J Nat Prod. 2011 Oct 28;74(10):2206-15
pestalospirane A  0   *Benzoxepins *Spiro Compounds. J Nat Prod. 2011 Oct 28;74(10):2206-15
massarigenin A  0   *Lactones *Spiro Compounds. Chirality. 2011 Sep;23(8):617-23
14,15,18,20-diepoxyturbinarin  0   *Spiro Compounds Stigmasterol/*analogs & derivatives. Nat Prod Res. 2011 Apr;25(7):723-9
3-(2'-fluoro-6',7'-dihydrospiro(piperidine-4,4'-thieno(3,2-c)pyran)-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide  0   *Spiro Compounds *Bicyclo Compounds, Heterocyclic Carbon Radioisotopes Ligands. J Nucl Med 2011 Oct;52(10):1638-45
sequosempervirin A  0   *Spiro Compounds. Org Lett. 2011 Sep 2;13(17):4640-3
4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro(2.4)heptane-5,6-diol  0   *Spiro Compounds Adenosine/*analogs & derivatives. Bioorg Med Chem Lett 2011 Jul 1;21(13):3982-5
XEN 907  0   *Indoles *Spiro Compounds. Bioorg Med Chem Lett 2011 Jun 15;21(12):3676-81
maldoxin  0   *Lactones *Spiro Compounds. Org Lett. 2011 Aug 19;13(16):4224-7
97-63 compound  0   *Heterocyclic Compounds, 1-Ring *Spiro Compounds Antimalarials. Arzneimittelforschung. 2011;61(7):425-32
8-(3-(4-chlorophenyl)prop-2-enoyl)-3-((3,4-dichlorophenyl)methyl)-1-oxa-3,8-diazaspiro(4.5)decan-2-one  0   *Oxazoles *Spiro Compounds. J Biol Chem 2011 Aug 19;286(33):29292-302
spiro-prorocentrimine  0   *Lactones *Spiro Compounds. Org Lett. 2011 Jul 15;13(14):3758-61
filifolinol acetate  0   *Benzofurans *Spiro Compounds. Nat Prod Commun. 2011 Jun;6(6):759-62
3,4-dehydrotheaspirone  0   *Spiro Compounds. Fitoterapia. 2011 Mar;82(2):225-9
spironaphthoxazine  0   *Oxazines *Spiro Compounds. Bioorg Med Chem 2011 Feb 1;19(3):1030-40
3-methoxy-1-oxa-2,7-diaza-7,10-ethanospiro(4.5)dec-2-ene  0   *Aza Compounds *Spiro Compounds. ChemMedChem. 2011 May 2;6(5):889-903
pinnarine  0   *Alkaloids *Spiro Compounds. J Nat Prod. 2011 May 27;74(5):1323-6
virgatolide B  0   *Furans *Spiro Compounds. Org Lett. 2011 May 20;13(10):2670-3
virgatolide C  0   *Furans *Spiro Compounds. Org Lett. 2011 May 20;13(10):2670-3
virgatolide A  0   *Furans *Spiro Compounds. Org Lett. 2011 May 20;13(10):2670-3
coixspiroenone  0   *Spiro Compounds. J Agric Food Chem 2011 Feb 23;59(4):1185-94
97-78 compound  0   *Heterocyclic Compounds, 1-Ring *Spiro Compounds Antimalarials. Arzneimittelforschung. 2011;61(2):120-5
1'-benzyl-3-(3-fluoropropyl)-3H-spiro((2)benzofuran-1,4'-piperidine)  0   *Piperidines *Spiro Compounds. Chirality. 2011 Feb;23(2):148-54
27-hydroxy-13-desmethyl spirolide C  0   *Spiro Compounds. Toxicon. 2010 Dec;56(8):1327-33
27-oxo-13,19-didesmethyl spirolide C  0   *Spiro Compounds. Toxicon. 2010 Dec;56(8):1327-33
5'-(2-fluorophenyl)-spiro(1-azabicyclo(2.2.2)octane-3,2'(3'H)-furo(2,3-b)pyridine)  0   *Spiro Compounds *Azabicyclo Compounds Receptors, Nicotinic. Eur J Pharmacol 2010 Oct 25;645(1-3):63-9
1',3'-dihydro-1'-ethanol-3',3'-dimethyl-8-methoxy-6-nitro-spiro(2H-1-benzopyran-2,2'-(2H)-indole)  0   *Benzopyrans *Spiro Compounds. Chem Res Toxicol 2010 Sep 20;23(9):1459-66
didemnaketal C  0   *Spiro Compounds *Terpenes. Org Lett. 2010 Nov 19;12(22):5354-7
didemnaketal A  0   *Spiro Compounds *Terpenes. Org Lett. 2010 Nov 19;12(22):5354-7
didemnaketal B  0   *Spiro Compounds *Terpenes. Org Lett. 2010 Nov 19;12(22):5354-7
dihypoestoxide  0   *Chromans *Spiro Compounds. Org Lett. 2010 Nov 19;12(22):5294-7
RKA 182  0   *Spiro Compounds *Tetraoxanes. Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5693-7
2'-deoxy-2'-spirocyclopropylcytidine  0   *Spiro Compounds Cytidine/*analogs & derivatives RNA Replicase/antagonists & inhibitors. J Med Chem 2010 Nov 25;53(22):8150-60
JB-788  0   *Pyridines *Spiro Compounds. Neuroscience. 2010 Sep 1;169(3):1337-46
spliceostatin A  0   *Pyrans *Spiro Compounds. Cancer Sci 2010 Nov;101(11):2483-9
2-((2,6-dichlorophenyl)carbonylamino)-3-((2,4,8-triaza-2-methyl-1-oxo-4-phenylspiro(4.5)dec-8-yl)carbonylamino)propanoic acid  0   *Spiro Compounds beta-Alanine/*analogs & derivatives Integrin alpha4beta1/antagonists & inhibitors. J Pharm Sci 2010 Sep;99(9):3986-4004
MK-0489  0   *Pyrrolidines *Spiro Compounds. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4399-405
(3,3')spiro((hexahydropyrrolo(1,2-a)pyrazine-1,4-dione)-6,3'-(2',3'-dihydrothieno(2,3-b)naphtho-4',9'-dione))  0   *Quinolines *Spiro Compounds. Br J Pharmacol 2010 Jun;160(4):931-40
pinnatoxin G  0   *Alkaloids *Spiro Compounds. J Agric Food Chem 2010 May 26;58(10):6532-42
pinnatoxin F  0   *Alkaloids *Spiro Compounds. J Agric Food Chem 2010 May 26;58(10):6532-42
pinnatoxin E  0   *Alkaloids *Spiro Compounds. J Agric Food Chem 2010 May 26;58(10):6532-42
N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro(4.5)decan-8-yl)ethyl)-2-naphthamide  0   *Naphthalenes *Spiro Compounds Phospholipase D/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6706-19
linderaspirone A  0   *Lactones *Spiro Compounds. Org Lett. 2010 Jul 16;12(14):3196-9
longianone  0   *Lactones *Spiro Compounds. J Org Chem. 2009 Aug 21;74(16):6339-42
7,9-diamino-10-(3'-phenoxypropyloxy)-6,8,10-triazaspiro(4.5)deca-6,8-diene  0   *Spiro Compounds *Triazines. Int J Oncol 2010 Jul;37(1):211-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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