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Spironolactone

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Definition: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)     
Pharmacological Action Aldosterone Antagonists; Diuretics 		Other names Spirolactone; von ct, spiro; ct Arzneimittel Brand of Spironolactone; Spirono Isis; SC9420; SC 9420; NovoSpiroton; Novo Spiroton; spiro von ct; duraspiron; ct-Arzneimittel Brand of Spironolactone; betapharm Brand of Spironolactone; W+Śrwag Brand of Spironolactone; Verospirone; Verospiron; Veroshpiron; Spirospare; Spironone; Spirono-Isis; SpirolangDrugs* : ALDACTONE; SPIRONOLACTONE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
yaoshanenolide B  0   Spironolactone/*analogs & derivatives. Org Lett. 2012 Feb 17;14(4):1004-7
yaoshanenolide A  0   Spironolactone/*analogs & derivatives. Org Lett. 2012 Feb 17;14(4):1004-7
naphthospironone  0   Spironolactone/*analogs & derivatives. Chemistry. 2010 Apr 6;16(13):3902-5
SC70303  0   Spironolactone/*analogs & derivatives. Pharm Res 2000 Nov;17(11):1426-31
eplerenone  0   Spironolactone/*analogs & derivatives.
Pharma Action Aldosterone Antagonists 		Curr Hypertens Rep 2000 Aug;2(4):378-83INSPRA; EPLERENONE
8-(3-(4-fluorobenzoyl)propyl)-1-methyl-1,3,8-triazaspiro(4,5)decan-4-one  0   *Spironolactone. Life Sci 1998;63(22):2001-13
8-(3-(4-iodobenzoyl)propyl)-1-methyl-1,3,8-triazaspiro(4,5)decan-4-one  0   *Spironolactone. Life Sci 1998;63(22):2001-13
spironolactone-beta-cyclodextrin complex  0   *Spironolactone *beta-Cyclodextrins. Br J Clin Pharmacol 1997 Jul;44(1):35-9
7alpha-(methylthio)spironolactone S-oxide  38753-75-2   Spironolactone/*analogs & derivatives. Chem Res Toxicol 1989 Mar-Apr;2(2):109
6,6-ethylene-15,16-methylene-3-oxo-17-pregn-4-ene-2,17-carbolactone  101765-35-9   Spironolactone/*analogs & derivatives. J Med Chem 1991;34(8):2464
6,7-epoxycanrenone  114577-01-4   Spironolactone/*analogs & derivatives. Steroids 1989;54(1):113
epoxymexrenone  107724-20-9   Spironolactone/*analogs & derivatives. J Steroid Biochem 1989;32(1B):223
SC 30822  61237-95-4   Spironolactone/*analogs & derivatives. J Chromatogr 1988;428(2):377
ZK 97894  97870-25-2   Spironolactone/*analogs & derivatives. Am J Physiol 1989;256(1 Pt 1):C121
dihydroxy-6,7-dihydrocanrenone  67483-35-6   Spironolactone/*analogs & derivatives. Arch Int Physiol Biochim 1987;95(4):373
ZK 91587  84542-26-7 3'H-Cyclopropa(15,16)pregna-4,15-diene-7,21-dicarboxylic acid, 15,16-dihydro-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,15alpha,16alpha,17alpha)  Spironolactone/*analogs & derivatives Mineralocorticoids/antagonists & inhibitors. Biochim Biophys Acta 1988;964(1):105
mespirenone  87952-98-5   Spironolactone/*analogs & derivatives. Arzneimittelforschung 1986;36(11):1561
lasilacton  124199-68-4   *Furosemide *Spironolactone Drug Combinations. Pharmatherapeutica 1986;4(8):473
7-propyl spirolactone  76676-33-0 Pregn-4-ene-21-carboxylic acid, 17-hydroxy-3-oxo-7-propyl-, gamma-lactone, (7alpha,17alpha)  Spironolactone/*analogs & derivatives. Biochem Biophys Res Commun 1986;134(1):261
6-hydroxy-7-thiomethylspirolactone  42219-60-3   Spironolactone/*analogs & derivatives. J Chromatogr 1985;341(2):279
7-thiomethylspirolactone  38753-77-4   Spironolactone/*analogs & derivatives. J Chromatogr 1985;341(2):279
bupranolol, spironolactone drug combination  0   *Bupranolol *Spironolactone Drug Combinations. Wien Med Wochenschr 1985;89(suppl):215
spiroprop  138230-23-6   *Propranolol *Spironolactone Drug Combinations. Drug Ther Bull 1985;23(8):31
RU 28318  76676-34-1 Pregn-4-ene-21-carboxylic acid, 17-hydroxy-3-oxo-7-propyl-, monopotassium salt, (7alpha,17alpha)  Spironolactone/*analogs & derivatives.
Pharma Action Aldosterone Antagonists 		J Steroid Biochem 1984;20(4A):853
7 alpha-thiospironolactone  38753-76-3   Spironolactone/*analogs & derivatives. Life Sci 1981;29(26):2727
SC 8109  1722-54-9   Spironolactone/*analogs & derivatives. Kidney Int 1981;20(1):1
spironolactone, althiazide drug combination  76270-06-9 Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, mixt. with 6-chloro-3,4-dihydro-3-((2-propenylthio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide  *Spironolactone *Sulfonamides Drug Combinations. J Int Med Res 1980;8(3):199
SC 25152  41020-65-9   Spironolactone/*analogs & derivatives. J Pharmacol Exp Ther 209(1):144;1979
prorenone  49848-04-6   Spironolactone/*analogs & derivatives. Adv Nephrol 7:210;1977; Can J Physiol Pharmacol 1983;61(1):23; Endocrinology 104(4):1194;1979
buthiazide, spironolactone drug combination  0 Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)-, mixt. with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide  *Hydrochlorothiazide *Spironolactone Drug Combinations. Aviat Space Environ Med 49(3):503;1978ALDACTAZIDE; SPIRONOLACTONE AND HYDROCHLOROTHIAZIDE; SPIRONOLACTONE W/ HYDROCHLOROTHIAZIDE
3-(3-oxo-7 alpha-methylsulfonyl-6 beta,17 beta- dihydroxy-4-androsten-17 alpha-yl)propionic acid gamma-lactone  0   Spironolactone/*analogs & derivatives. Steroids 28(4):467;1976
prorenoate potassium  49848-01-3   Spironolactone/*analogs & derivatives. Br J Clin Pharmacol 3(3):475;1976; Clin Pharmacol Ther 18(4):391;1975; Clin Sci Mol Med 51:333;1976; Endocrinology 104(4):1194;1979; Eur J Clin Pharmacol 9(5-6):381;1976; J Endocrinol 70(2):173;1976; J Pharmacol Exp Ther 194(2):450;1975
SC 26304  41020-79-5 3-(3-oxo-7 alpha-carboxyisopropyl-17 beta-hydroxy-4-androstene-17 alpha yl)propionic acid gamma lactone  Spironolactone/*analogs & derivatives. Clin Exptl Pharmacol Physiol Suppl 2:99;1975; J Membrane Biol 41:15;1978; J Steroid Biochem 9(3):265;1978; Proc Nat Acad Sci USA 71(4):1431;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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