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Stearoyl-CoA Desaturase

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Definition: An enzyme that catalyzes the formation of oleoyl-CoA, A, and water from stearoyl-CoA, AH2, and oxygen where AH2 is an unspecified hydrogen donor.      Other names Stearyl-CoA Desaturase; delta 9 Desaturase; Stearyl CoA Desaturase; Stearoyl CoA Desaturase; Desaturase, delta-9; Desaturase, Stearyl-CoA; Desaturase, Stearoyl-CoA; Desaturase, Stearate; delta-9 Desaturase; Stearate Desaturase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid  0   *Acetic Acids *Tetrazoles Stearoyl-CoA Desaturase/antagonists & inhibitors. J Med Chem 2011 Jul 28;54(14):5082-96
1'-(6-(5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl)pyridazin-3-yl)-5-(trifluoromethyl)-3,4-dihydrospiro(chromene-2,4'-piperidine)  0   *Benzopyrans *Piperidines Stearoyl-CoA Desaturase/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Jan 15;20(2):746-54
MF 438  0   *Pyridazines *Thiadiazoles Stearoyl-CoA Desaturase/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Jan 15;20(2):499-502
2-(6-(4-(2-chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole  0   *Oxadiazoles *Pyridazines Stearoyl-CoA Desaturase/antagonists & inhibitors. J Med Chem 2007 Jun 28;50(13):3086-100
4-(2-chlorophenoxy)-N-(3-(methyl carbamoyl)phenyl)piperidine-1-carboxamide  0   *Piperidines Stearoyl-CoA Desaturase/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Aug 1;18(15):4298-302
SCD1 protein, human  EC 1.14.99.5   *Stearoyl-CoA Desaturase. Obesity (Silver Spring) 2007 Jul;15(7):1732-40
SCD5 protein, human  EC 1.14.99.5   *Stearoyl-CoA Desaturase. Biochem Biophys Res Commun 2005 Jul 8;332(3):735-42
Scd1 protein, mouse  EC 1.14.99.5   *Stearoyl-CoA Desaturase.
Scd4 protein, mouse  EC 1.14.99.5   *Stearoyl-CoA Desaturase. J Biol Chem 2003 Sep 5;278(36):33904-11
delta 6-desaturase, rat  EC 1.14.99.-   *Stearoyl-CoA Desaturase. J Lipid Res 2003 Mar;44(3):450-4
FAR-17c protein, Mesocricetus auratus  EC 1.14.19.1   *Stearoyl-CoA Desaturase. Dermatology 1998;196(1):47-50

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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