encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

Steroid Hydroxylases

More information in Books or onNLM PubMed
Definition: Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.  GEN; prefer specifics   
Examples Aldosterone Synthase; Aromatase; Cholesterol 7-alpha-Hydroxylase; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 CYP27A1; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Steroid 12-alpha-Hydroxylase; Steroid 16-alpha-Hydroxylase; Steroid 17-alpha-Hydroxylase; Steroid 11-beta-Hydroxylase; Steroid 21-Hydroxylase; Sterol 14-Demethylase 		Other names Steroid Monooxygenases; Monooxygenases, Steroid; Hydroxylases, Steroid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,4-estrogen hydroxylase, human  EC 1.14.14.1   *Steroid Hydroxylases. Vopr Onkol. 2011;57(6):722-6
cholesterol 25-hydroxylase  EC 1.14.99.38   *Steroid Hydroxylases. Neurosci Lett. 2006 Jan 2;391(3):142-6
CYP39A1 protein, human  EC 1.14.13.-   *Steroid Hydroxylases.
CYP7B1 protein, human  EC 1.14.13.-   *Steroid Hydroxylases.
Cyp7b1 protein, rat  EC 1.14.13.-   *Steroid Hydroxylases.
Cyp2a4 protein, mouse  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases.
Cyp2a1 protein, rat  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases.
VID 400  0   *Imidazoles Steroid Hydroxylases/antagonists & inhibitors. Steroids 2001 Mar-May;66(3-5):451-62
SDZ 89-443  0   *Imidazoles Steroid Hydroxylases/antagonists & inhibitors. Steroids 2001 Mar-May;66(3-5):451-62
vitamin D 1-alpha hydroxylase  EC 1.14.-   *Steroid Hydroxylases. J Endocrinol 2000 Mar;164(3):339-48
Cyp2b9 protein, mouse  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1999 Sep 1;369(1):89-99
cholesterol 24-hydroxylase  EC 1.14.-   *Steroid Hydroxylases. Curr Opin Lipidol 1999 Apr;10(2):161-5
oxysterol 7-alpha-hydroxylase  EC 1.14.13.-   *Steroid Hydroxylases. J Clin Invest 1998 Nov 1;102(9):1690-703
CPD protein, Arabidopsis  EC 1.14.-   *Steroid Hydroxylases *Arabidopsis Proteins. Cell 1996 Apr 19;85(2):171-82
cytochrome P-450 CYP2G1  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1997 Apr 15;340(2):208-14; Biochem Biophys Res Commun 1996 Jan 17;218(2):570-4
saturated steroid 6-alpha-hydroxylase  EC 1.14.99.-   *Steroid Hydroxylases. J Clin Endocrinol 1997 May;82(5):1338-44; J Steroid Biochem. 1986 Dec;25(6):911-6; Steroids. 1979 Jun;33(6):675-92
Cyp2b10 protein, mouse  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Biochem Biophys Res Commun 1996 Sep 24;226(3):900-5
Cyp7b1 protein, mouse  EC 1.14.13.-   *Steroid Hydroxylases. J Biol Chem 1995 Dec 15;270(50):29739-45
taurochenodeoxycholic acid 6-alpha-hydroxylase  EC 1.14.99.-   *Steroid Hydroxylases. Biochem J 2002 Apr 15;363(Pt 2):297-303; Eur J Biochem 1995 Aug 1;231(1):855-61
testosterone 2-alpha-hydroxylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1995 Jan 10;316(1):478-84
cytochrome P-450 CYP2B5 (rabbit)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1994 Nov 1;314(2):367-75
cytochrome P-450 CYP2B11 (dog)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases Steroid Hydroxylases. Arch Biochem Biophys 1994 Nov 1;314(2):367-75
CYP2K1 protein, Oncorhynchus mykiss  EC 1.14.14.1   *Fish Proteins *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 1994 Jul;312(1):45-51
steroid 14-alpha-hydroxylase  EC 1.14.13.-   *Steroid Hydroxylases. J Steroid Biochem Mol Biol 1993 Jun;45(6):563-9
steroid 11-alpha-hydroxylase  EC 1.14.99.-   *Steroid Hydroxylases. J Basic Microbiol 1991;31(5):347-56
cytochrome P450 CYP3A10 (hamster)  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. J Biol Chem 1991;266(31):21031
cytochrome P450(C-MF)  EC 1.14.-   *Steroid Hydroxylases. Biochem Biophys Res Commun 1988;156(2):681
digitoxin 12-beta-hydroxylase  EC 1.14.99.-   *Steroid Hydroxylases. Biochem J 1988;252(2):537
steroid 15-alpha-hydroxylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Biochemistry 1986;25(17):4913
steroid (23R)-hydroxylase  EC 1.14.99.-   *Steroid Hydroxylases. Biochim Biophys Acta 1986;883(3):585
steroid 9-alpha-hydroxylase  EC 1.14.99.-   *Steroid Hydroxylases. Eur J Biochem 1982;128(1):125
steroid 15-beta-hydroxylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Biochem Biophys Res Commun 1982;105(1):303
steroid hormone 7-alpha-hydroxylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Steroids 1980;36(6):647
steroid 19-hydroxylase  EC 1.14.13.-   *Steroid Hydroxylases. Prod Soc Exp Biol Med 1980;165(1):69
steroid 16-beta-hydroxylase  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1998 Nov; 121(1-3):197-203; FEBS Lett 1980;113(2):193
testosterone 7-alpha-hydroxylase, hamster  EC 1.14.14.1   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Arch Biochem Biophys 371(2):270;1999
steroid hormone 6-beta-hydroxylase  EC 1.14.14.1   *Steroid Hydroxylases. Metabolism 27(8):1003;1978
vitamin D 24-hydroxylase  EC 1.14.13.-   *Steroid Hydroxylases. Biochem Biophys Res Comms 81(4):1073;1978; Biochem Biophys Res Commun 90(1):50;1979; J Biol Chem 1979;254(24):12455; J Biol Chem 253(11):3804;1978; Methods Enzymol 1980;67:445
estrogen 2-hydroxylase  EC 1.14.14.1   *Steroid Hydroxylases *Cytochrome P-450 CYP1A1. Biochem Pharmacol 1980;29(1):83; Cancer Res 1979;39(11):4584; Steroids 32(4):529;1978
ecdysone 20-hydroxylase  EC 1.14.99.22   *Aryl Hydrocarbon Hydroxylases *Steroid Hydroxylases. Eur J Biochem 88(1):37;1978; Hoppe Seylers Z Phyiol Chem 359(10):1247;1978

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy