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Steroid 17-alpha-Hydroxylase

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Definition: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.     
See Also Adrenal Hyperplasia, Congenital 		Other names Steroid 17-Monooxygenase; Steroid 17-Hydroxylase; Steroid 17 alpha-Monooxygenase; P450(c17); Cytochrome P-450(17 alpha); CYP17; 17,20-Lyase; 17 alpha-Hydroxylase; 17,20-Desmolase; alpha-Monooxygenase, Steroid 17; alpha-Hydroxyprogesterone Aldolase, 17; alpha-Hydroxylase, 17; Steroid 17 alpha Monooxygenase; Steroid 17 alpha Hydroxylase; Steroid 17 Monooxygenase; Steroid 17 Hydroxylase; Aldolase, Hydroxyprogesterone; Aldolase, 17 alpha-Hydroxyprogesterone; 17-alpha-Hydroxylase, Steroid; 17-Monooxygenase, Steroid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4'-(pyridin-4-ylmethyl)biphenyl-3,4-diol  0   *Biphenyl Compounds *Pyridines Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5749-58
4'-(pyridin-4-ylmethyl)biphenyl-3-amine  0   *Biphenyl Compounds *Pyridines Steroid 11-beta-Hydroxylase/antagonists & inhibitors Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5749-58
CYP17A1 protein, human  EC 1.14.99.9   *Steroid 17-alpha-Hydroxylase. Hum Genet 2005 May;116(6):539
3-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene  0   *Androstadienes *Benzimidazoles Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2972-84
3-hydroxy-17-(imidazol-1-yl)androsta-5,16-diene  0   *Androstadienes *Imidazoles Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Steroid Biochem Mol Biol 2004 Oct;92(3):155-65
22-iminopregn-5-en-3-ol  0   *Imines Pregnenolone/*analogs & derivatives Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 2000 Nov 16;43(23):4437-45
17-(3-pyridyl)-16,17-epoxy-5alpha-androst-3-ol  0   *Androstanols *Pyridines Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 1998 Dec 31;41(27):5375-81
17-(4-pyridyl)androst-5-en-3-ol  0   *Androstenols *Pyridines Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 1998 Dec 31;41(27):5375-81
YM 116  0   *Carbazoles *Imidazoles Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. Prostate 1998 Sep 15;37(1):10-8
1-methyl-2-(1-hydroxyiminoethyl)-6-methoxy-3,4-dihydronaphthalene  0   *Imines *Naphthalenes Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. Arch Pharm (Weinheim) 1997 Nov;330(11):359-61
20-hydroxy-21,21,21,-trifluoropregn-4-en-3-one  0   *Pregnenes Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. Steroids 1997 Jun;62(6):468-73
4-tert-butylcyclohexyl 4-pyridylacetate  129175-17-3   *Pyridines Steroid 17-alpha-Hydroxylase/antagonists & inhibitors Aromatase Inhibitors. J Med Chem 1990;33(11):3055
17-(cyclopropylamino)androst-5-en-3-ol  120973-21-9   *Androstenols Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. Biochem Biophys Res Commun 1989;162(3):1571
22-amino-23,24-bisnor-5-cholen-3-ol  78949-97-0   *Pregnenes Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. Arch Biochem Biophys 1985;242(1):297
progesterone 17-alpha-hydroxylase  EC 1.14.99.9   *Steroid 17-alpha-Hydroxylase. J Steroid Biochem 11(2):1151;1979; J Steroid Biochem 7(8):571;1976
pregnenolone 17-alpha-hydroxylase  EC 1.14.99.9   *Steroid 17-alpha-Hydroxylase. J Steroid Biochem 11(2):1151;1979; J Steroid Biochem 7(8):571;1976; Steroids 1979;34(7):817
17 beta-ureido-1,4-androstadien-3-one  32012-41-2 Urea, ((17beta)-3-oxoandrosta-1,4-dien-17-yl)  *Androstadienes Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Endocrinol 71(3):289;1976
16 beta-bromo-3 beta,17 alpha-dihydroxy-5 alpha-pregnane-11,20-dione  1780-98-9   *Pregnanediones Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Endocrinol 71(3):289;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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