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Steroid 21-Hydroxylase

More information in Books or onNLM PubMed
Definition: An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).      Other names Steroid 21-Monooxygenase; Cytochrome P-450 CYP21; Steroid 21 Monooxygenase; Steroid 21 Hydroxylase; Progesterone 21 Hydroxylase; P-450 c21, Cytochrome; Cytochrome P 450 c21; Cytochrome P 450 CYP21; Cytochrome P 450 21 Hydroxylase; 21 Hydroxylase; Steroid-21-Hydroxylase; Progesterone 21-Hydroxylase; Cytochrome P450c21; Cytochrome P-450(c-21); Cytochrome P-450 c21; Cytochrome P-450 21-Hydroxylase; 21-Hydroxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CYP21A1P protein, human  EC 1.14.99.10   *Steroid 21-Hydroxylase. Clin Chem. 2012 Feb;58(2):421-30
Cyp21a1 protein, rat  EC 1.14.99.10   *Steroid 21-Hydroxylase.
Cyp21a1 protein, mouse  EC 1.14.99.10   *Steroid 21-Hydroxylase.
CYP21A2 protein, human  EC 1.14.99.10   *Steroid 21-Hydroxylase Adrenal Hyperplasia, Congenital.
Cyp2c6 protein, rat  EC 1.14.14.1   *Steroid 21-Hydroxylase. Can J Physiol Pharmacol 1994 Apr;72(4):397-401
CYP2C5 protein, Oryctolagus cuniculus  EC 1.14.14.1   *Steroid 21-Hydroxylase. J Biol Chem 1990;265(24):14662

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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