encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 
ψ 

Substance P

More information in Books or onNLM PubMed
Definition: An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.     
Pharmacological Action Neurotransmitter Agents
See Also Receptors, Neurokinin-1 		Other names Substance P, Hypothalamic; Substance P, Euler-Gaddum; P, Substance; P, Hypothalamic Substance; P, Euler-Gaddum Substance; Euler Gaddum Substance P; Hypothalamic Substance P; Euler-Gaddum Substance P; SP(1-11)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
substance P, 213Bi-DOTA(thienylalanyl(8)-methionyl(O2)(11))  0   *Organometallic Compounds Substance P/*analogs & derivatives Bismuth. Eur J Nucl Med Mol Imaging 2010 Jul;37(7):1335-44
substance P (6-11), Phe(7)-His(9)  0   *Peptide Fragments Substance P/*analogs & derivatives. Pharmacol Biochem Behav 2003 Jan;74(2):487-93
substance P, 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-arginyl(1)  0   *Heterocyclic Compounds, 1-Ring Substance P/*analogs & derivatives. Clin Cancer Res 2006 Jun 15;12(12):3843-50
substance P-metabolite 5-11  0   *Peptide Fragments *Substance P. Scand J Immunol 2006 Jan;63(1):42-9
substance P (6-11), Tyr(6)-D-Phe(7)-D-His(9)  0   *Peptide Fragments Substance P/*analogs & derivatives. Exp Neurol 2005 Feb;191(2):285-91
2-(4-fluorophenyl)-1-(3-oxo-(2H,4H)-1,2,4-triazol-5-ylmethyl)-3-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)morpholine  0   *Morpholines *Triazoles Substance P/antagonists & inhibitors. Chemistry 2002 Mar 15;8(6):1372-6
substance P-saporin  0   *Ribosome Inactivating Proteins, Type 1 Substance P/*analogs & derivatives. J Neurosci 2002 Oct 15;22(20):9086-98
SP31 ScFv  0   *Single-Chain Antibodies Recombinant Proteins Substance P. Anal Biochem 2000 Sep 10;284(2):221-30
spantide III  0   Substance P/*analogs & derivatives Substance P/antagonists & inhibitors. Endocr Regul 2000 Mar;34(1):13-8
substance P, desArg(1)  0   Substance P/*analogs & derivatives. J Mass Spectrom 2000 Feb;35(2):183-8
cyclo(Trp-Pro-Lys-Trp-Phe)  0   *Peptides, Cyclic Substance P. Biopolymers 1999 Aug;50(2):211-9
substance P, biotinyl-apa-Pro(9)-MePhe(pBz)(10)-Trp(11)  0   Biotin/*analogs & derivatives Substance P/*analogs & derivatives Substance P/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Jun 2;8(11):1369-74
NY 3640  0   Substance P/*analogs & derivatives. Peptides 1998;19(9):1519-23
N-(tert-butoxycarbonyl)-N-methyl-4-benzoylphenylalanine  0   *Phenylalanine Substance P/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Jun 2;8911):1369-74
substance P, Cys(3,6)-Tyr(8)-Pro(9)  0   Substance P/*analogs & derivatives Receptors, Neurokinin-1/agonists. J Neurophysiol 1998 Jul;80(1):218-29
substance P, Arg(1)-Pro(2)-Phe(7)-His(9)  0   Substance P/*analogs & derivatives Receptors, Neurokinin-1/antagonists & inhibitors. J Med Chem 1998 Apr 23;41(9):1497-506
substance P, Leu(11),CH2NH-(10-11)  0   Substance P/*analogs & derivatives Substance P/antagonists & inhibitors. Am J Physiol 1997 Jul;273(1 Pt 2):R28-34
propionyl-(Met(O2)11)substance P(7-11)  0   *Peptide Fragments Substance P/*analogs & derivatives. Mol Pharmacol 1997 Jul;52(1):120-7
substance P, Arg(1)-Trp(5,7,9)-Leu(11)  0   Substance P/*analogs & derivatives. J Biol Chem 1996 Nov 15;271(46):29453-60
substance P, Bpa(8)  130409-05-1   Substance P/*analogs & derivatives. J Biol Chem 1996 Oct 18;271(42):25797-800
substance P (3-4)  0   *Substance P. Biull Eksp Biol Med 1996 Apr;121(4):399-403
substance P, Indium-111-DTPA-Arg(1)  0   Pentetic Acid/*analogs & derivatives Substance P/*analogs & derivatives Indium Radioisotopes. J Nucl Med 1996 Jan;37(1):108-17
substance P (5-11), Glp(5)-Glu(O-benzyl)(11)  0   *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives Substance P/*analogs & derivatives Receptors, Neurokinin-1/agonists. Int J Pept Protein Res 1995 Jun;45(6):508-13
substance P (6-11), Glp(6)-Glu(O-benzyl)(11)  0   *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives Substance P/*analogs & derivatives Receptors, Neurokinin-1/agonists. Int J Pept Protein Res 1995 Jun;45(6):508-13
NY 3238  0   Substance P/*analogs & derivatives. Int J Cancer 1995 Jan 3;60(1):82-7
GPAnt-2  0   *Oligopeptides Pyrrolidonecarboxylic Acid/*analogs & derivatives Substance P. Cell Mol Biol (Noisy-Le-grand) 1994 Jul;40(5):707-15
tryptophyl(7)-sendide  0   *Peptide Fragments *Substance P. Brain Res 1994 Jun 27;649(1-2):319-22
substance P (1-7), Pro(2)-Phe(7)  0   Substance P/*analogs & derivatives. J Neurosci 1994 May;14(5 Pt 2):3364-9
substance P (6-11)-O-benzyl, Orn(6)-Glu(O-benzyl)(11)  0   *Peptide Fragments Substance P/*analogs & derivatives. Neuropeptides 1994 Jan;26(1):55-7
substance P(4-11), beta Ala(4)-Ser(9)-Met(O2)(11)  0   *Peptide Fragments Substance P/*analogs & derivatives. Neuropeptides 1993 Jun;24(6):335-41
substance P (6-11), pGlu(6)-N-MePhe(8)-Aib(9)  0   *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives Substance P/*analogs & derivatives. Biopolymers 1993 Jun;33(6):915-26
substance P (4-11), Pro(4)-Trp(2,9,10)  0   Substance P/*analogs & derivatives. Int Arch Allergy Immunol 1993;101(2):190-5
substance P (6-11), Ac(Arg(6)-Sar(9)-Met(O2)(11))  0   *Peptide Fragments Substance P/*analogs & derivatives. Life Sci 1993;52(13):103-6
galanin (1-13)-spantide amide  143868-20-6   *Galanin *Peptide Fragments Substance P/*analogs & derivatives. Brain Res 1993 Jan 15;600(2):268-72
substance P (6-11), Orn(6)  102979-72-6   *Peptide Fragments Substance P/*analogs & derivatives. Int J Pept Protein Res 1992 Nov;40(5):395-400
Substance P (1-6)  68232-52-0 Substance P, 7-de-L-phenylalanine-8-de-L-phenylalanine-9-deglycine-10-de-L-leucine-11-de-L-methioninamide  *Peptide Fragments *Substance P. Biochem Pharmacol 1992 Nov 3;44(9):1773-7
GR 71251  127493-01-0 Substance P, 9-deglycine-10-((5S)-6-oxo-L-alpha-(2-methylpropyl)-1,7-diazaspiro(4.4)nonane-7-acetic acid)-11-L-tryptophanamide  Substance P/*analogs & derivatives. Br J Pharmacol 1992 Apr;105(4):805-10
substance P, N-spermine-Gln(5)  141231-59-6   Substance P/*analogs & derivatives. Peptides 1992 Jan-Feb;13(1):151-4
galantide  138579-66-5 L-Methioninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl  Substance P/*analogs & derivatives Galanin/*analogs & derivatives. Eur J Pharmacol 1992 Jan 14;210(2):183-8
delta-Ava-Pro(9)-substance P (7-11)  136912-73-7 L-Methionine, N-(N-(1-(N-(N-(5-amino-1-oxopentyl)-L-phenylalanyl)-L-phenylalanyl)-D-prolyl)-L-leucyl)  *Peptide Fragments Substance P/*analogs & derivatives. Neuropeptides 1991;19(2):119
substance P (6-11), pGlu(6)-Phe(8)-psi-(methyleneoxy)-Gly(9)  98900-29-9   *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives Substance P/*analogs & derivatives. J Med Chem 1991;34(8):2430
substance P (4-11), Pro(4)-Trp-(7,9,10)-Phe(11)  89457-20-5   *Peptide Fragments Substance P/*analogs & derivatives. Pain 1991;44(2):178
substance P (6-11), Glp(6)-iodo-Tyr(8)  70082-71-2   *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives Substance P/*analogs & derivatives. Int J Biochem 1991;23(3):317
substance P, biotin-NTE-Arg(3)  137084-95-8   Substance P/*analogs & derivatives. Lab Invest 1991;64(5):703
GR 73632  133156-06-6 L-Methioninamide, N-(5-amino-1-oxopentyl)-L-phenylalanyl-L-phenylalanyl-L-prolyl-N-methyl-L-leucyl  *Peptide Fragments Substance P/*analogs & derivatives. Agents Actions Suppl 1990;31:205
substance P, Pro(9)  104486-69-3   Substance P/*analogs & derivatives. J Neurochem 1991;56(3):879
CP 96345  132746-60-2   *Biphenyl Compounds Substance P/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Hypnotics and Sedatives 		Science 1991;251(4992):435
septide, acetyl-Arg(6)  116097-84-8   Substance P/*analogs & derivatives. Br J Pharmacol 1990;100(4):711
spantide II  129176-97-2 L-Norleucinamide, N6-(3-pyridinylcarbonyl)-D-lysyl-L-prolyl-3-(3-pyridinyl)-L-alanyl-L-prolyl-3,4-dichloro-D-phenylalanyl-L-asparaginyl-D-tryptophyl-L-phenylalanyl-D-tryptophyl-L-leucyl  Substance P/*analogs & derivatives Substance P/antagonists & inhibitors.
Pharma Action Analgesics 		Regul Pept 1990;29(1):1
substance P (6-11), N(1,6)(beta-glucopyranosyl)Glu(5)-Pro(9)  125741-45-9   *Peptide Fragments Substance P/*analogs & derivatives. J Pharm Sci 1990;79(1):74
substance P, Sar(9)-Met(O2)(11)  110880-55-2   Substance P/*analogs & derivatives Receptors, Neurokinin-3/antagonists & inhibitors. Naunyn Schmiedebergs Arch Pharmacol 1989;340(5):547
substance P, Arg(1)-Pro(2)-Trp(7,9)  83440-04-4   Substance P/*analogs & derivatives. Ophthalmic Res 1989;21(5):360
substance P (7-11)  51165-05-0   *Peptide Fragments *Substance P. Naunyn Schmiedebergs Arch Pharmacol 1989;340(1):107
substance P (4-11), beta-Ala(4)-Sar(9)-Met(02)(11)  110863-38-2   *Peptide Fragments Substance P/*analogs & derivatives. Peptides 1989;10(3):671
substance P (6-11), Glu(Glc)(6)  128022-96-8   *Peptide Fragments Substance P/*analogs & derivatives. Int J Pept Protein Res 1989;33(5):335
substance P (6-11), Glu(6)  123067-53-8   *Peptide Fragments Substance P/*analogs & derivatives. Int J Pept Protein Res 1989;33(5):335
substance P (5-11), Asp(5,6)-MePhe(8)  104499-97-0   *Peptide Fragments Substance P/*analogs & derivatives Receptors, Neurokinin-3/antagonists & inhibitors. Neurosci Lett 1988;92(3):341
substance P, Arg(1)-Cl2-Phe(5)-Asn(6)-Trp(7,9)-Nle(11)  108376-57-4   Substance P/*analogs & derivatives. Br J Pharmacol 1988;94(3):707
substance P, Pro(9)-Met(O2)(11)  110880-54-1   Substance P/*analogs & derivatives. Eur J Pharmacol 1988;150(3):377
substance P (5-11), cyclo(11-5(epsilon))Lys(5)  0   *Peptide Fragments Substance P/*analogs & derivatives. Bioorg Khim 1987;13(12):1619
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy