encyclopedia of medical concepts
ψ 

Sulfhydryl Reagents

More information in Books or onNLM PubMed
Definition: Chemical agents that react with SH groups. This is a chemically diverse group that is used for a variety of purposes. Among these are enzyme inhibition, enzyme reactivation or protection, and labelling.  do not confuse with SULFHYDRYL COMPOUNDS   
See Also Enzyme Inhibitors 		Other names Thiol Reagents; Sulfhydryl Compound Inhibitors; Sulfhydryl Compound Antagonists; SH-Reagents; SH Reagents; Reagents, Thiol; Reagents, Sulfhydryl; Inhibitors, Sulfhydryl Compounds; Inhibitors, Sulfhydryl Compound; Compound Inhibitors, Sulfhydryl; Compound Antagonists, Sulfhydryl; Antagonists, Sulfhydryl Compounds; Antagonists, Sulfhydryl Compound; Sulfhydryl Compounds Inhibitors; Sulfhydryl Compounds Antagonists
Substances having this pharmacologic action: p-Chloromercuribenzoic Acid; Diamide; Chloromercuribenzoates; Chloromercurinitrophenols; 4-Chloromercuribenzenesulfonate; Arsenicals; Showdomycin; Mercuribenzoates; Dithioerythritol; Dithionitrobenzoic Acid; Hydroxymercuribenzoates; Ethylmaleimide; Cystamine; (2-sulfonatoethyl)methanethiosulfonate; (2-(trimethylammonium)ethyl)methanethiosulfonate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-((methylsulfonyl)thio)ethyl (N-(N,N-dimethylamino)ethyl)carbamate  187592-54-7   *Carbamates *Sulfones Sulfhydryl Reagents. Biochemistry 1997 Feb 11;36(6):1343-8
2-nitro-1-(4,5-dimethoxy-2-nitrophenyl)ethene  0   *Nitrobenzenes beta-Galactosidase/antagonists & inhibitors Sulfhydryl Reagents. Biochim Biophys Acta 1996 Apr 16;1293(2):238-42
4-acetamido-4'-((iodoacetyl)amino)stilbene-2,2'-disulfonate  0   *Stilbenes Sulfhydryl Reagents. FEBS Lett 1994 Dec 12;356(1):66-71
4-(N,N-dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole  150993-62-7   *Oxadiazoles *Pyrrolidines Sulfhydryl Reagents. Biomed Chromatogr 1994 Mar-Apr;8(2):85-9
n-octyl-5-dithio-2-nitrobenzoic acid  146019-29-6   *Disulfides *Nitrobenzoates Sulfhydryl Reagents. Anal Biochem 1993 Feb 1;208(2):357-62
4-bromomethyl-3-nitrobenzoic acid  55715-03-2   *Nitrobenzoates Sulfhydryl Reagents. Biochem Int 1992 Apr;26(5):943-51
8-thiocyano-adenosine triphosphate  139041-17-1   Adenosine Triphosphate/*analogs & derivatives Sulfhydryl Reagents. Biochemistry 1992 Feb 25;31(7):2107-13
3-(2-pyridyldithio)propionylarginylmonoiodotyrosine  138191-81-8   *Dipeptides Sulfhydryl Reagents. Anal Biochem 1991 Oct;198(1):165-73
3-maleimidopropionylarginylmonoiodotyrosine  138191-82-9   *Dipeptides Sulfhydryl Reagents. Anal Biochem 1991 Oct;198(1):165-73
4,4'-dimethoxytrityloxy-S-(2-thio-5-nitropyridyl)-2-mercaptoethane  131384-76-4   *Pyridines *Trityl Compounds Sulfhydryl Reagents. Anal Biochem 1990;189(2):173
S-(bismaleimidoethyl ether)cysteine  124505-88-0   *Maleimides Cysteine/*analogs & derivatives Sulfhydryl Reagents. Biochem J 1989;263(3):875
4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole  98358-90-8 4-Benzofurazansulfonamide, 7-fluoro-N,N-dimethyl  *Oxazoles *Sulfonamides Sulfhydryl Reagents. Analyst 1989;114(4):413
1-(4-chlorophenyl)-4,4-dimethyl-5-diethylamino-1-penten-3-one  121229-92-3   *Chlorobenzenes *Ketones Mannich Bases Sulfhydryl Reagents. Anal Biochem 1989;177(2):237
3-bromopyruvamide  35293-21-1   *Pyruvates Sulfhydryl Reagents. Biomed Biochim Acta 1988;47(1):9
pyridyldithioethylamine  83578-21-6   *Disulfides *Pyridines Sulfhydryl Reagents. Biochemistry 1988;27(3):848
phenyldichloroarsine  696-28-6   *Arsenicals Sulfhydryl Reagents. Arch Biochem Biophys 1987;257(2):293
4-(hydroxybutyl)dichloroarsine  28440-95-1   *Arsenicals Sulfhydryl Reagents. Biochemistry 1987;26(3):863
benzophenone-4-iodoacetamide  76809-63-7   *Benzophenones Sulfhydryl Reagents. Proc Natl Acad Sci USA 1986;83(17):6392
(2-nitroaniline-N-ethyldithio)-2-(pyridyl-5-thioureido-N'-(5-fluorescein))  101613-93-8   *Fluoresceins Thiourea/*analogs & derivatives Sulfhydryl Reagents. Anal Biochem 1986;153(2):336
4,4'-diaminodiphenyldisulfide  722-27-0   *Aniline Compounds Sulfhydryl Reagents. Biochim Biophys Acta 1985;830(1):71
glutathione maleimide  137593-43-2   *Maleimides Sulfhydryl Reagents. J Biol Chem 1985;260(1):462
glutathione hexane maleimide  0   *Maleimides Sulfhydryl Reagents. Eur J Biochem 1983;135(1):41
N-(4-(2-benzoxazolyl)phenyl)maleimide  16707-41-8   *Maleimides Sulfhydryl Reagents. J Chromatogr 1983;275(1):89
7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate  84806-27-9 4-Benzofurazansulfonic acid, 7-fluoro-, ammonium salt  *Fluorobenzenes Sulfhydryl Reagents.
Pharma Action Fluorescent Dyes 		Anal Biochem 1983;128(2):471
warburganal  62994-47-2   *Sesquiterpenes Allergens Sulfhydryl Reagents. Arch Dermatol Res 1982;274(3-4):277
methyl 2-pyridyl disulfide  63434-91-3 Pyridine, 2-(methyldithio)  *Pyridines Sulfhydryl Reagents. Anal Biochem 1982;122(2):274
3-nitro-2-pyridyl disulfide  82650-28-0 Pyridine, 2-(methyldithio)-3-nitro  *Pyridines Sulfhydryl Reagents. Anal Biochem 1982;122(2):274
tetramethylrhodamine iodoacetamide  81235-33-8 Xanthylium, 9-(2-carboxyphenyl)-3,6-bis(dimethylamino)-, mono((iodoacetyl)amino) deriv., chloride  *Rhodamines Sulfhydryl Reagents.
Pharma Action Fluorescent Dyes 		Arch Biochem Biophys 1982;216(1):133
4-nitrobenzyl selenosulfuric acid  82571-50-4 Selenosulfuric acid, Se-((4-nitrophenyl)methyl) ester  *Nitrobenzenes *Organoselenium Compounds Sulfhydryl Reagents. Biochem J 1982;201(2):305
benzylselenium sulfuric acid  82571-51-5 Selenosulfuric acid, Se-(phenylmethyl) ester  *Organoselenium Compounds Sulfhydryl Reagents. Biochem J 1982;201(2):305
4-chloro-7-sulfobenzofurazan  81377-14-2 4-Benzofurazansulfonic acid, 7-chloro-, ammonium salt  *Benzoxazoles Sulfhydryl Reagents. Arch Biochem Biophys 1982;214(1):386
N-(2,2,2-trifluoroethoxycarbonyl)imidazole  81265-32-9 1H-Imidazole-1-carboxylic acid, 2,2,2-trifluoroethyl ester  *Imidazoles Sulfhydryl Reagents. Biochim Biophys Acta 1982;701(2):153
6,6'-diselenobis-(3-nitrobenzoic acid)  80180-68-3 Benzoic acid, 2,2'-diselenobis(5-nitro)  Dithionitrobenzoic Acid/*analogs & derivatives Sulfhydryl Reagents. Anal Biochem 1981;117(1):94
4-aminophenylarsenoxide  1122-90-3   *Arsenicals Sulfhydryl Reagents. Eur J Biochem 1981;118(3):541
mercury orange  3076-91-3   *Phenylmercury Compounds Sulfhydryl Reagents. Pol J Pharmacol 1980;32(4):557; Verh Anat Ges 69;249;1975
monobromobimane  71418-44-5 1H,7H-pyrazolo(1,2-a)pyrazole-1,7-dione, 3-(bromomethyl)-2,5,6-trimethyl  *Bicyclo Compounds Sulfhydryl Reagents.
Pharma Action Fluorescent Dyes 		Histochemistry 1980;68(3):309
N-(beta-iodoethyl)trifluoroacetamide  0   Trifluoroacetic Acid/*analogs & derivatives Sulfhydryl Reagents. Anal Biochem 1980;106(1):43
2-chloromercuri-4-nitrophenol  24579-90-6   *Chloromercurinitrophenols Sulfhydryl Reagents. J Biol Chem 1980;255(15):7296
L589-420  1431-30-7 2,3-dichloro-4-(2-ethylidinebutyryl)phenoxyacetic acid  *Glycolates Sulfhydryl Reagents. Can J Physiol Pharmacol 51(9):642;1973
ethylacetylacrylate  6742-53-6 4-oxo-2-pentenoic acid, ethyl ester  *Acrylates Sulfhydryl Reagents. Biochim Biophys Acta 1980;621(2):338
methoxycarbonyl-coenzyme A disulfide  72205-57-3 Coenzyme A, S-(O-methyl carbono(dithioperoxoate))  *Coenzyme A Sulfhydryl Reagents. J Biol Chem 254(23):11988;1979
N-(methoxypolyethylene glycol)-4-hydroxymercuribenzamide  71861-55-7 Poly(oxy-1,2-ethanediyl), alpha-(2-((4-(hydroxymercurio)benzoyl)amino)ethyl)-omega-methoxy  *Mercuribenzoates *Polyethylene Glycols Sulfhydryl Reagents. Contraception 20(2):159;1979
2-(4'-maleimidylanilino)naphthalene-6-sulfonic acid  71936-81-7 2-Naphthalenesulfonic acid, 6-((4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl)amino)-, monosodium salt  *Anilino Naphthalenesulfonates Sulfhydryl Reagents. J Biol Chem 254(20):10362;1979
tetracyanoaurate(III)  22806-79-7 (SP-4-1)-tetrakis(cyano-C)aurate(1-)  *Cyanides *Gold Compounds Sulfhydryl Reagents. Biochim Biophys Acta 579(1):234;1979
N-(7-dimethylamino-4-methylcoumarinyl)maleimide  55145-14-7   *Maleimides Sulfhydryl Reagents.
Pharma Action Fluorescent Dyes ; Indicators and Reagents 		Acta Derm Venereol (Stockh) 58(5):391;1978; Anal Biochem 79(1&2):83;1977; Anal Biochem 90(1):300;1978; Arch Dermatol Res 264(1):77;1979; J Biochem (Tokyo) 1980;87(2):593; J Histochem Cytochem 1979;27(5):942; Jpn J Dermatol 88(2):93;1978
2,2'-dihydroxy-6,6'-dinaphthyldisulfide  6088-51-3 6,6'-dithiobis-2-naphthalenol  *Disulfides Sulfhydryl Reagents. Acta Histochem (Suppl) (Jena) 16:183;1976
sodium arsenite  13768-07-5   *Sodium Compounds *Arsenites Sulfhydryl Reagents.
Pharma Action Enzyme Inhibitors 		Biochim Biophys Acta 1980;606(1):170; J Gen Microbiol 108(1):119;1978; Toxicol Appl Pharmacol 1980;52(2):245
CMB-dextran  37307-31-6 Dextran, 2-((4-(chloromercurio)benzoyl)amino)ethyl ether  *Chloromercuribenzoates *Dextrans Sulfhydryl Reagents. Agents Actions 5:236;1975
benzofuroxan  480-96-6 benzofurazan 1-oxide  *Benzoxazoles Sulfhydryl Reagents. Biochem J 161(3):627;1977; Biochem J 167:799;1977; Cancer Res 35(12):3735;1975
2-methyl-N-benzenesulfonyl-N(4)-bromoacetylquinonediimide  62442-86-8 Acetamide, 2-bromo-N-(3-methyl-4-((phenylsulfonyl)imino)-2,5-cyclohexadien-1-ylidene)  *Imides Sulfhydryl Reagents. J Am Chem Soc 99(6):1984;1977
diazenedicarboxylic acid bis(N'-methylpiperazide)  53202-52-1   *Azo Compounds Sulfhydryl Reagents. Brain Res 117(2):277;1976; Eur J Biochem 1979;100(2):393
bromoacetylsulfanilic acid  61389-09-1   *Sulfanilic Acids Sulfhydryl Reagents. FEBS Lett 70(1):76;1976
bromoacetylaminoisophthalic acid  61389-10-4   *Phthalic Acids Sulfhydryl Reagents. FEBS Lett 70(1):76;1976
alpha-bromo-4-hydroxy-3-nitroacetophenone  5029-61-8   *Acetophenones Sulfhydryl Reagents. J Am Chem Soc 98(20):6369;1976
2,4-dimethoxybenzylamine  20781-20-8   *Benzylamines Sulfhydryl Reagents. Eur J Pharmacol 36(1):41;1976
N-(4-carboxy-3-hydroxyphenyl)maleimide  19232-43-0 Benzoic acid, 4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-2-hydroxy  *Maleimides Sulfhydryl Reagents. Biol Reprod 14(5):632;1976; Rec Adv Human Reprod W3 EX89 ICS 370:322;1974
N-acetylimidazole  2466-76-4   *Imidazoles Sulfhydryl Reagents. Biochemistry 17(15):3001;1978; Biochim Biophys Acta 1980;611(2):217; Europ J Pharmacol 36(1):41;1976
2,2'-dithiobis(5-nitropyridine)  2127-10-8   *Pyridines Sulfhydryl Reagents. Biochim Biophys Acta 423(3):590;1976; Biochim Biophys Acta 459(1):20;1977
1,4-(N-2-aminoethyl-2'-pyridyl disulfide)-7-nitrobenzo-2-oxa-1,3-diazole  58210-58-5 4-Benzofurazanamine, 7-nitro-N-(2-(2-pyridinyldithio)ethyl)  *Benzoxazoles Sulfhydryl Reagents. Biochem J 151(2):417;1975; Biochem J 1979;183(2):223
4-aminophenylmercuriacetate  6283-24-5 (acetato-O)(4-aminophenyl)mercury  Phenylmercuric Acetate/*analogs & derivatives Sulfhydryl Reagents. Anal Biochem 68(2):349;1975; Biochim Biophys Acta 483(2):493;1977; FEBS Lett 53(1):23;1975; J Membrane Biol 23(3-4):249;1975; Lancet 2(8033):333;1977
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy