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Sulindac

More information in Books or onNLM PubMed
Definition: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.     
Pharmacological Action Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cyclooxygenase Inhibitors 		Other names Nu Sulindac; Nu Pharm Brand of Sulindac; Novo Sundac; MK231; MK 231; Apo Sulin; Sulindal; Nu-Sulindac; Nu-Pharm Brand of Sulindac; Novopharm Brand of Sulindac; Novo-Sundac; Merck Sharp & Dohme Brand of Sulindac; Merck Brand of Sulindac; MK-231; Klinoril; Kendrick Brand of Sulindac; Kenalin; Copal; Clinoril; ChibretDrugs* : SULINDAC; CLINORIL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid 4-(5-thioxo-5H-1,2-dithiol-3-yl)-phenyl ester  0   *Thiones Sulindac/*analogs & derivatives. Biochem Pharmacol. 2012 Mar 15;83(6):715-22.
OXT-328  0   *Organophosphorus Compounds Sulindac/*analogs & derivatives. Gastroenterology. 2010 Oct;139(4):1320-32
sulindac sulfide amide  0   Sulindac/*analogs & derivatives. Cancer Prev Res (Phila Pa). 2009 Jun;2(6):572-80
S-sulindac  0   Sulindac/*analogs & derivatives. Clin Cancer Res 2009 Mar 15;15(6):1964-72
2-(1-benzylidene-5-bromo-2-methyl-1H-inden-3-yl)acetic acid  0   Sulindac/*analogs & derivatives. Br J Pharmacol 2007 Dec;152(8):1207-14
(5-fluoro-2-methyl-1-(3,5-dimethoxy-4-hydroxybenzylidene)-3-(N-benzyl)indene)acetamide  0   Sulindac/*analogs & derivatives. Mol Cancer Ther 2006 Jan;5(1):60-7
sulindac derivative IND 12  0   Sulindac/*analogs & derivatives. Cancer Res 2002 Mar 15;62(6):1718-23
(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride  0   Sulindac/*analogs & derivatives Phosphodiesterase Inhibitors. J Pharmacol Exp Ther 2001 Nov;299(2):583-92
nitrosulindac  0   Sulindac/*analogs & derivatives. Biochem Biophys Res Commun 2001 Jun 15;284(3):808-16
sulindac sulfone  59864-04-9   Sulindac/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Anticarcinogenic Agents ; Cyclooxygenase Inhibitors 		Biochim Biophys Acta 1980;618(2):318
sulindac sulfide  32004-67-4 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-(4-(methylthio)phenyl)methylene-, (Z)  Sulindac/*analogs & derivatives.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Antineoplastic Agents ; Tocolytic Agents 		Biochim Biophys Acta 1980;618(2):318

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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