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Suramin

More information in Books or onNLM PubMed
Definition: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.     
Pharmacological Action Antinematodal Agents; Antineoplastic Agents; Trypanocidal Agents 		Other names Sodium, Suramin; Salt Suramin, Monosodium; Salt Suramin, Hexasodium; Monosodium Salt Suramin; Hexasodium Salt Suramin; Suramin, Monosodium Salt; Suramin, Hexasodium Salt; Suramin Sodium; Naphuride; Naganol; Naganin; Moranil; Germanin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NF157 compound  0   Suramin/*analogs & derivatives. J Med Chem 2005 Nov 3;48(22):7040-8
NF676 compound  0   Suramin/*analogs & derivatives. Br J Pharmacol. 2005 Oct;146(4):525-33
8,8',8'',8'''-(carbonylbis(imino-5,13-benzenetriyl-bis(carbonylimino)))tetrakisnaphthalene-1,3,5-trisulfonic acid  0   Suramin/*analogs & derivatives Receptors, Purinergic P2/antagonists & inhibitors. Naunyn Schmiedebergs Arch Pharmacol 2005 Jul;372(1):1-13
6-((4,6,8-trisulfo-1-naphthyl)iminocarbonyl-1,3-(4-methylphenylene)iminocarbonyl-1,3-phenyleneazo)pyridoxal-5'-phosphate  0   Pyridoxal Phosphate/*analogs & derivatives Suramin/*analogs & derivatives Receptors, Purinergic P2. J Auton Nerv Syst 2000 Jul 3;81(1-3):171-7
XAMR 0721  0   Suramin/*analogs & derivatives. Cancer Chemother Pharmacol 1999;43(4):341-7
NF 279  0   Suramin/*analogs & derivatives Receptors, Purinergic/antagonists & inhibitors. Eur J Pharmacol 1998 May 29;350(1):R5-6
NF023  0   Suramin/*analogs & derivatives. Br J Pharmacol 1997 Mar;120(5):954-60

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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