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Tacrine

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Definition: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.     
Pharmacological Action Cholinesterase Inhibitors; Nootropic Agents; Parasympathomimetics 		Other names Tetrahydroaminoacridine; Woods Brand of Tacrine Hydrochloride; Tenakrin; Tacrine Hydrochloride; Romotal; Parke Davis Brand of Tacrine Hydrochloride; OTL Pharm Brand of Tacrine Hydrochloride; Horizon Brand of Tacrine Hydrochloride; Cognex; 9-Amino-1,2,3,4-Tetrahydroacridine; 1,2,3,4-Tetrahydroaminoacridine; 1,2,3,4-Tetrahydro-9-acridinamine; THADrugs* : COGNEX
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-hydroxy-4-oxo-N-(10-((1,2,3,4-tetrahydroacridin-9-yl)amino)decyl)-4H-chromene-2-carboxamide  0   *Chromones Tacrine/*analogs & derivatives Butyrylcholinesterase Cholinesterase Inhibitors Amyloid Precursor Protein Secretases/antagonists & inhibitors. J Med Chem. 2012 Feb 9;55(3):1303-17.
bis(propyl)cognitin  0   Tacrine/*analogs & derivatives Receptors, GABA-A Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. J Biol Chem 2010 Jun 25;285(26):19947-58
lipocrine  0   Thioctic Acid/*analogs & derivatives Tacrine/*analogs & derivatives. J Med Chem 2005 Jan 27;48(2):360-3
TZ2PA6 compound  0   *Phenanthridines Tacrine/*analogs & derivatives Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2005 Dec 29;48(26):8155-62
(9-amino-5,6,7,8-tetrahydroacridin-4-yl)methanol  0   Tacrine/*analogs & derivatives Acetylcholinesterase/antagonists & inhibitors. J Med Chem 2005 Nov 17;48(23):7496-9
ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzo(1,8)naphthyridine-3-carboxylate  0   Tacrine/*analogs & derivatives Acetylcholinesterase/antagonists & inhibitors. J Pharmacol Exp Ther 2004 Sep;310(3):987-94
N-butyramide-tacrine  0   Tacrine/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):285-90
7-bromotacrine  53970-68-6   Tacrine/*analogs & derivatives. J Med Chem 2000 May 18;43(10):2007-18
1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine  0   Tacrine/*analogs & derivatives Acetylcholinesterase. Chung Kuo Yao Li Hsueh Pao 1999 Mar;20(3):211-7
3-hydroxytacrine  0   Tacrine/*analogs & derivatives. J Med Chem 1996 Jul 19;39(15):3014-8
6-chlorotacrine  0   Tacrine/*analogs & derivatives. Biopolymers 1996 Jan;38(1):109-17
2-tert-butyl-9-amino-1,2,3,4-tetrahydroacridine  0   Tacrine/*analogs & derivatives. Hum Exp Toxicol 1995 Jun;14(6):469-74
9-(3-(2-nitro-1-imidazolyl)propylamino)-1,2,3,4-tetrahydroacridine  163714-83-8   Tacrine/*analogs & derivatives. Oncol Res 1994;6(9):439-48
THB 013  0   Tacrine/*analogs & derivatives. J Neural Transm Park Dis Dement Sect 1994;8(1-2):139-48
2-hydroxytacrine  0   Tacrine/*analogs & derivatives. J Pharm Sci 1994 Nov;83(11):1582-5
4-hydroxytacrine  0   Tacrine/*analogs & derivatives. J Pharm Sci 1994 Nov;83(11):1582-5
N-methyltacrine  136297-33-1   Tacrine/*analogs & derivatives Carbon Radioisotopes. Eur J Pharmacol 1993 May 19;236(2):229-38
9-hydroxylamine-1,2,3,4-tetrahydroacridine  118976-89-9   Tacrine/*analogs & derivatives. J Chromatogr 1989;487(2):401
velnacrine  104675-29-8   Tacrine/*analogs & derivatives Alzheimer Disease/drug therapy.
Pharma Action Cholinesterase Inhibitors 		J Med Chem 1988;31(7):1278
9-amino-10-methyl-1,2,3,4-tetrahydroacridine  316-88-1   Tacrine/*analogs & derivatives. Sb Ved Pr Lek Fak Univ Karlovy 1984;27(4):477
centbucridine  82636-28-0 4-Acridinamine, N-butyl-1,2,3,4-tetrahydro-, monohydrochloride  Tacrine/*analogs & derivatives. Anesth Analg (Cleve) 1983;62(1):109
7-methoxytacrine  5778-80-3 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine  Tacrine/*analogs & derivatives. Activit Nerv Super 20(1):79;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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