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Tamoxifen

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Definition: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.     
Pharmacological Action Antineoplastic Agents, Hormonal; Bone Density Conservation Agents; Estrogen Antagonists; Selective Estrogen Receptor Modulators
Examples Raloxifene; Toremifene 		Other names ICI47699; ICI46474; ICI46,474; ICI 47699; ICI 46474; ICI 46,474; Citrate, Tamoxifen; Zitazonium; Tomaxithen; Tamoxifen Citrate; Soltamox; Savient brand of Tamoxifen Citrate; Novaldex; Nolvadex; ICI-47699; ICI-46474; ICI-46,474Drugs* : SOLTAMOX; NOLVADEX; TAMOXIFEN CITRATE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-hydroxyospemifene  0   Tamoxifen/*analogs & derivatives. Menopause. 2012 Jan;19(1):96-103
Isotretinoin embryopathy like syndrome  0   Tamoxifen/adverse effects *Abnormalities, Drug-Induced.
(Z)-2-(2-(4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy)ethoxy)ethanol  0   Tamoxifen/*analogs & derivatives. J Pharmacol Exp Ther 2008 Oct;327(1):58-67
ridaifen-B  0   *Pyrrolidines Tamoxifen/*analogs & derivatives. Cancer Sci 2008 Mar;99(3):608-14
tamoxifen-pyropheophorbide conjugate  0   *Porphyrins Tamoxifen/*analogs & derivatives. J Cell Biochem 2006 Oct 15;99(3):665-70
alpha,4-dihydroxytamoxifen  0   Tamoxifen/*analogs & derivatives. Chem Res Toxicol 2005 Oct;18(10):1611-8
alpha-hydroxy-N,N-didesmethyltamoxifen  0   Tamoxifen/*analogs & derivatives. Chem Res Toxicol. 2003 Sep;16(9):1090-8
alpha-(deoxyguanosin-N(2)-yl)-N,N-didesmethyltamoxifen  0   Tamoxifen/*analogs & derivatives. Chem Res Toxicol. 2003 Sep;16(9):1090-8
hydroxytamoxifen  0   Tamoxifen/*analogs & derivatives. Hum Reprod. 2003 Jan;18(1):100-7
ethylbromide tamoxifen  0   Tamoxifen/*analogs & derivatives. Mol Pharmacol 2002 May;61(5):1105-13
boroxifen  0   Tamoxifen/*analogs & derivatives. J Org Chem 2002 Jan 25;67(2):383-7
alpha-(N(2)-deoxyguanosinyl)tamoxifen N-oxide  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis. 2000 Sep;21(9):1737-44
DBPT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Br J Cancer 2000 Jun;82(11):1759-63
DBCT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Br J Cancer 2000 Mar;82(6):1158-62
3,4-dihydroxytamoxifen  0   *Quinones Tamoxifen/*analogs & derivatives. Chem Res Toxicol 2000 Jan;13(1):53-62
3,4-dihydroxytamoxifen-o-quinone  0   *Quinones Tamoxifen/*analogs & derivatives. Chem Res Toxicol 2000 Jan;13(1)53-62
iodomethyl-N,N-diethyltamoxifen  0   Tamoxifen/*analogs & derivatives Iodine Radioisotopes Ligands. Eur J Nucl Med 1999 Oct;26(10):1259-64
N,N-didesmethyltamoxifen  0   Tamoxifen/*analogs & derivatives. Carcinogenesis 1999 Oct;20(10):2011-60
tamoxifen catechol  0   *Catechols *Tamoxifen. Drug Metab Dispos 1999 Jun;27(6):681-8
2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol  0   Tamoxifen/*analogs & derivatives. J Chromatogr B Biomed Sci Appl 1999 Mar 5;724(1):163-71
FCT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Nitrosourea Compounds Tamoxifen. Melanoma Res 1998 Dec;8(6):565-72
alpha-hydroxytamoxifen  0   Tamoxifen/*analogs & derivatives. Cancer Res 1998 Feb 15;58(4):647-53
DAVTHML regimen  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluoxymesterone Methotrexate Mitolactol Tamoxifen Vincristine. Am J Clin Oncol 1998 Feb;21(1):99-104
alpha-sulfate tamoxifen  0   Tamoxifen/*analogs & derivatives DNA Adducts. Chem Res Toxicol 1997 Feb;10(2):189-96
alpha-(N(2)-deoxyguanosinyl)tamoxifen  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):529-43
4-(4-(2-(dimethylamino)ethoxy)phenyl)-3,4-diphenyl-2-(9beta-deoxyribofuranosyl-6-oxopurin-2-ylamino)-3-butene  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):529-43
alpha-(N(6)-deoxyadenosinyl)tamoxifen  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):529-43
alpha-acetoxytamoxifen  0   Tamoxifen/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):529-43
TEMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Etoposide Mitoxantrone Tamoxifen. Cancer 1996 Nov 1;78(9):1906-11
tamoxifen methiodide  107256-99-5   Tamoxifen/*analogs & derivatives. Cancer Res 1996 Oct 1;56(19):4328-31
indometafen  0   Tamoxifen/*analogs & derivatives Delayed-Action Preparations. Patol Fiziol Eksp Ter 1994 Jul-Sep;(3):20-2
tamoxifen 1,2-epoxide  0   Tamoxifen/*analogs & derivatives. Carcinogenesis 1994 May;15(5):793-5
CEFT protocol  0   Tamoxifen *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Fluorouracil Epirubicin. Gan To Kagaku Ryoho 1993 Jun;20(8):1067-70
CDPTH regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Fluoxymesterone Mitolactol Prednisone Tamoxifen. Ann Oncol 1992 Nov;3(9):768-70
CMFPTH regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Fluorouracil Fluoxymesterone Methotrexate Prednisone Tamoxifen. Ann Oncol 1992 Nov;3(9):768-70
1,1-dichloro-2,3-diphenyl-2-(4-methoxyphenyl)cyclopropane  131544-74-6   Tamoxifen/*analogs & derivatives. Anticancer Res 1992 May-Jun;12(3):585-90
pyrrolidino-4-iodotamoxifen  116057-75-1   Tamoxifen/*analogs & derivatives.
Pharma Action Estrogen Antagonists 		Cancer Res 1991;51(21):5851
DBPT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Oncology (Williston Park) 1991;5(5):95
2-methyl-4-hydroxytamoxifen  96474-35-0   Tamoxifen/*analogs & derivatives. Endocrinology 1991;128(6):3283
tamoxifen acid  97818-93-4   Tamoxifen/*analogs & derivatives. Drug Metab Dispos 1990;18(5):645
4-iodo-tamoxifen  116057-68-2   Tamoxifen/*analogs & derivatives. Biochem Pharmacol 1990;40(10):2277
TAT 59  115767-74-3 Phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-(4-(1-methylethyl)phenyl)-1-butenyl)-, dihydrogen phosphate (ester), (E)  Tamoxifen/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Estrogen Antagonists 		Eur J Cancer 1990;26(3):397
2-(4-(1-(4-hydroxyphenyl)-2-(4-isopropylphenyl)-1-butenyl)phenoxy)-N,N-dimethylethylamine  129612-87-9   Tamoxifen/*analogs & derivatives. Cancer Res 1990;50(13):3866
PFT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Melphalan Tamoxifen. J Clin Oncol 1990;8(6):1005
PAFT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluorouracil Melphalan Tamoxifen. J Clin Oncol 1990;8(6):1005
ACT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Tamoxifen. J Clin Oncol 1990;8(6):1005
4-hydroxytamoxifen beta-glucuronide  128255-45-8   Tamoxifen/*analogs & derivatives. Biochem Pharmacol 1990;39(9):1459
N-desmethyltoremifene  110503-61-2   Tamoxifen/*analogs & derivatives. Cancer Chemother Pharmacol 1990;25(4):247
4-hydroxytoremifene  110503-62-3   Tamoxifen/*analogs & derivatives. Cancer Chemother Pharmacol 1990;25(4):247
CAPT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Prednisolone Tamoxifen. Gan To Kagaku Ryoho 1989;16(2):243
ACFT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Tegafur Tamoxifen. Gan To Kagaku Ryoho 1988;15(5):1711
4-hydroxy-N-desmethyltamoxifen  110025-28-0   Tamoxifen/*analogs & derivatives. Cancer Res 1988;48(8):2304
iododesethyltamoxifen aziridine  113202-48-5   Tamoxifen/*analogs & derivatives. Steroids 1986;48(5-6):287
dihydrotamoxifen  109640-20-2   Tamoxifen/*analogs & derivatives. J Med Chem 1987;30(10):1761
ICI 142269  77207-49-9   Tamoxifen/*analogs & derivatives. J Steroid Biochem 1987;26(5):547
(1-(4-dimethylaminoethoxy)phenyl)-1-(4-hydroxyphenyl)-2-bromo-2-phenylethylene  106692-19-7   Tamoxifen/*analogs & derivatives. Int J Rad Appl Instrum (B) 1986;13(4):483
CMFPT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Fluorouracil Methotrexate Prednisone Tamoxifen. NCI Monogr 1986;(1):75
TAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Tamoxifen. Gynecol Oncol 1986;25(3):340
6,7-dihydro-8-phenyl-9-(4-(2-(dimethylamino)ethoxy)phenyl)-5-H-benzocycloheptene  103304-52-5   Tamoxifen/*analogs & derivatives. J Med Chem 1986;29(10):2053
N-(2-chloroethyl)-N'-2-(4-(1,2-diphenylbutenyl)phenoxy)ethyl-N-nitrosourea  104691-78-3   Tamoxifen/*analogs & derivatives. Breast Cancer Res Treat 1986;7(2):77
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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