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Tetrahydronaphthalenes

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Definition: Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.     
Examples 8-Hydroxy-2-(di-n-propylamino)tetralin; Levobunolol; Mibefradil; Podophyllotoxin; Tetralones 		Other names Tetralins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-((1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl))-N-(8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)cyclohexylcarboxamide  0   *Heterocyclic Compounds, 3-Ring *Tetrahydronaphthalenes. J Med Chem. 2012 Jan 26;55(2):697-708.
(S)-7-methoxy-2-aminotetraline  0   *Tetrahydronaphthalenes. Biosci Biotechnol Biochem. 2011;75(11):2093-8
(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)dimethylammonium  0   *Tetrahydronaphthalenes. Neuropsychopharmacology 2010 Dec;35(13):2564-78
confertifolin  0   *Furans *Tetrahydronaphthalenes Oils, Volatile. Pharm Biol. 2010 Feb;48(2):187-90
A-995662  0   *Tetrahydronaphthalenes. Pain. 2010 Aug;150(2):319-26
6-((2-(4-(biphenyl-4-yl)piperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol  0   *Biphenyl Compounds *Piperazines *Tetrahydronaphthalenes. Bioorg Med Chem. 2010 Aug 1;18(15):5661-74
6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid-(1-(4-(3-hydroxyphenyl)dimethylpiperidinylmethyl)methylpropyl)amide  0   *Piperidines *Tetrahydronaphthalenes Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2010 Jul 22;53(14):5290-301
2-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide  0   *Tetrahydronaphthalenes Valine/*analogs & derivatives Amyloid Precursor Protein Secretases/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Jul;334(1):269-77
2-hydroxy-3-(4-(4-fluorobenzoyl)piperidino)tetralin  0   *Piperidines *Tetrahydronaphthalenes Fluorine Radioisotopes. J Med Chem 2009 Mar 12;52(5):1358-69
2-amino-nonyl-6-methoxyl-tetralin muriate  0   *Tetrahydronaphthalenes. Acta Pharmacol Sin. 2010 May;31(5):616-28
NBRI17671  0   *Tetrahydronaphthalenes. J Antibiot (Tokyo). 2010 May;63(5):237-43
2-(4-((benzylmethylamino)methyl)benzylidene)-6-(5-piperidin-1-yl-pentyloxy)-3,4-dihydro-2H-naphthalen-1-one  0   *Benzylamines *Tetrahydronaphthalenes. Bioorg Med Chem 2010 Mar 1;18(5):1749-60
2-(4-((benzylmethylamino)methyl)benzylidene)-6-(5-diethylaminopentyloxy)-3,4-dihydro-2H-naphthalen-1-one  0   *Benzylamines *Tetrahydronaphthalenes. Bioorg Med Chem 2010 Mar 1;18(5):1749-60
JBIR-22  0   *Pyrrolidinones *Tetrahydronaphthalenes. J Nat Prod. 2010 Apr 23;73(4):628-31
IT-M-07000  0   *Phenylpropionates *Tetrahydronaphthalenes. Biol Pharm Bull 2009 Dec;32(12):1997-2001
EC23 compound  0   *Tetrahydronaphthalenes *Benzoic Acids. Mol Biosyst 2009 May;5(5):458-71
EC19 compound  0   *Tetrahydronaphthalenes *Benzoic Acids. Mol Biosyst 2009 May;5(5):458-71
N-(3-cyano-5-fluoro-4-(methylsulfonamido)benzyl)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)propanamide  0   *Sulfonamides *Tetrahydronaphthalenes. Bioorg Med Chem 2009 May 15;17(10):3557-67
1,3-diphenyl-1,2,3,4-tetrahydro-1-naphthol  0   *Naphthols *Tetrahydronaphthalenes. Acta Crystallogr C 2009 Feb;65(Pt 2):o35-8
8-methoxy-2-propionamidotetralin  0   *Tetrahydronaphthalenes. Reproduction. 2008 Nov;136(5):533-41
1-keto-2-(p-dimethylaminobenzal)-tetrahydronaphthalene  0   *Tetrahydronaphthalenes. Spectrochim Acta A Mol Biomol Spectrosc. 2008 Sep;70(4):888-91
N-(5,6,7,8-tetrahydronaphthalen-2-yl)guanidine  0   *Guanidines *Tetrahydronaphthalenes. J Med Chem 2008 Jun 12;51(11):3304-12
2-hydroxy-5-(3-iodoprop-2-en-1-oxy)-3-(4-phenylpiperidino)tetralin  0   *Piperidines *Tetrahydronaphthalenes Iodine Radioisotopes Ligands. Nucl Med Biol 2007 Nov;34(8):967-71
UVI 3003  0   *Coumaric Acids *Tetrahydronaphthalenes Retinoid X Receptors/agonists. Proc Natl Acad Sci U S A 2007 Oct 30;104(44):17323-8
CD 3254  0   *Coumaric Acids *Tetrahydronaphthalenes Retinoid X Receptors/agonists. Proc Natl Acad Sci U S A 2007 Oct 30;104(44):17323-8
1-acetyl-5-bromo-2,3-dihydro-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-Indole-7-sulfonamide  0   *Sulfonamides *Tetrahydronaphthalenes. Biol Pharm Bull 2007 Mar;30(3):502-7
bupleurumin  0   *Lactones *Tetrahydronaphthalenes. Arch Pharm Res 2007 May;30(5):561-4
ST-1942  0   *Tetrahydronaphthalenes. Neuropsychopharmacology. 2007 Jun;32(6):1302-11
N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid  0   *Tetrahydronaphthalenes. Alcohol Alcohol 2007 Jan-Feb;42(1):11-8
7,8-dihydroxycalamenene  0   *Tetrahydronaphthalenes. Org Lett 2006 Nov 9;8(23):5315-6
carneic acid B  0   *Tetrahydronaphthalenes. J Nat Prod 2006 Aug;69(8):1198-202
carneic acid A  0   *Tetrahydronaphthalenes. J Nat Prod 2006 Aug;69(8):1198-202
AS 19 compound  0   *Pyrazoles *Tetrahydronaphthalenes. Behav Brain Res 2005 Aug 30;163(1):136-40
isocatalpanol  0   *Tetrahydronaphthalenes. Magn Reson Chem 2005 Jul;43(7):582-4
burseranin  0   *Tetrahydronaphthalenes. Chem Pharm Bull (Tokyo). 2005 Feb;53(2):229-31
(5,6,7,8-tetrahydronaphthalen-1-yl)-(2-(1H-tetrazol-5-yl)phenyl)amine  0   *Tetrahydronaphthalenes *Tetrazoles. J Pharmacol Exp Ther 2005 Apr;313(1):250-9
4-(2-methylthiophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide  0   *Piperazines *Tetrahydronaphthalenes Receptors, Serotonin/agonists. J Med Chem 2004 Dec 16;47(26):6616-24
5-hydroxy-2-(N-propyl-N-(5'-fluoropentyl))aminotetralin  0   *Tetrahydronaphthalenes Fluorine Radioisotopes Receptors, Dopamine D2 Receptors, Dopamine D2/agonists. Nucl Med Biol 2004 Apr;31(3):303-11
ST1214  0   *Tetrahydronaphthalenes. Shock 2004 Jan;21(1):77-85
FR901512  0   *Tetrahydronaphthalenes. J Antibiot (Tokyo). 2004 Apr;57(4):264-70
sikkimotoxin  0   *Lignans *Tetrahydronaphthalenes. J Nat Prod 2004 Apr;67(4); 697-9
6-(4-(N,N-dimethylaminoethoxy)-5,6,7,8-tetrahydronaphthalen-1-yl)pyridin-2-ylamine  0   *Aminopyridines *Tetrahydronaphthalenes Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1575-86
cytosporic acid  0   *Tetrahydronaphthalenes. J Nat Prod 2003 Apr;66(4):551-3
5-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)methyl)-N-(2,4,6-trimethoxyphenyl)-2-furamide  0   *Anilides *Tetrahydronaphthalenes Gonadotropin-Releasing Hormone/antagonists & inhibitors. J Pharmacol Exp Ther 2003 May;305(2):688-95
vulcanolide  0   *Tetrahydronaphthalenes. Chemistry. 2002 Feb 15;8(4):853-8
scaphopetalone  0   *Tetrahydronaphthalenes Guaiacol/*analogs & derivatives. Phytochemistry 2003 Feb;62(4):647-50
5,8-dihydroxy-3-methyl-2-(dipropylamino)-1,2,3,4-tetrahydronaphthalene  0   *Tetrahydronaphthalenes. Bioorg Med Chem 2002 Nov;10(11):3565-9
N-((4-dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide  0   *Aniline Compounds *Tetrahydronaphthalenes. J Biol Chem 2002 Dec 20;277(51):49403-7
5,6-dihydroxy-3,4-dihydrospiro(naphthalene-1(2H)-3'-piperidine)  0   *Spiro Compounds *Tetrahydronaphthalenes. J Pharm Pharmacol. 2002 May;54(5):649-60
6,7-dihydroxy-3,4-dihydrospiro(naphthalene-1(2H)-3'-piperidine)  0   *Spiro Compounds *Tetrahydronaphthalenes Catecholamines. J Pharm Pharmacol. 2002 May;54(5):649-60
AG045572  0   *Furans *Tetrahydronaphthalenes. Pharm Res 2002 Feb;19(2):202-8
2-methyl-5,6,7,8-tetrahydro-6-(methylamino)-1,2-naphthalenediyl ester hydrochloride  0   *Tetrahydronaphthalenes. Biopolymers 2002;67(4-5):289-93
1,2-diacetyltetramethyltetralin  0   *Tetrahydronaphthalenes. J Am Chem Soc 2002 Mar 20;124(11):2744-52
CJ 17572  0   Pyrrolidinones Tetrahydronaphthalenes. J Antibiot (Tokyo) 2002 Jan;55(1):19-24
N-(5-(1H-imidazol-4-y1)-5,6,7,8-tetrahydro-1-naphthalenyl)methanesulfonamide  0   *Imidazoles *Tetrahydronaphthalenes. Life Sci 2001 Nov 30;70(2):181-97
cagayanin  0   *Tetrahydronaphthalenes *Lignans. J Org Chem 2001 Dec 14;66(25):8606-11
(3,5,5,8,8,-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl) (5 carboxypyrid-2-yl)sulfide  0   *Fatty Acids, Unsaturated *Tetrahydronaphthalenes. Biochem Pharmacol 2001 Dec 1;62(11):1501-9
isoshinanolone  0   *Tetrahydronaphthalenes Plant Extracts. Phytochemistry 2001 Feb;56(4):387-91
4-(5-(5,6,7,8-tetrahydro-5,5,8,8--tetramethylnaphthalen-2-yl)isoxazol-3-yl)benzoic acid  0   *Isoxazoles *Tetrahydronaphthalenes Apoptosis. J Med Chem 2001 Jul 5;44(14):2308-18
AGN 194204  0   *Fatty Acids, Unsaturated *Tetrahydronaphthalenes Ligands. J Med Chem 2001 Jul 5;44(14):2298-303
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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