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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.  /defic: consider also HOMOCYSTINURIA; DF: note short X ref   
See Also Homocystinuria 		Other names Tetrahydropteroylglutamate Methyltransferase; Methyltetrahydrofolate Homocysteine Methyltransfer; Methionine Synthetase; Synthetase, Methionine; Synthase, Methionine; S-Methyltransferase, 5-Methyltetrahydrofolate-Homo; Methyltransferase, Tetrahydropteroylglutamate; Methyltransferase, Methyltetrahydrofolate Homocyst; Homocysteine Methyltransferase, Methyltetrahydrofo; Vitamin B12-Independent Methionine Synthase; Vitamin B12-Dependent Methionine Synthase; Methionine Synthase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Arakawa syndrome 2  0   *Amino Acid Metabolism, Inborn Errors 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/deficiency.
N-(4-((2-(2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl)methyl)amino)-3-bromobenzoyl)glutamic acid  0   *Glutamates *Pyrimidines 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/antagonists & inhibitors. Anticancer Drugs 2008 Aug;19(7):697-704
diethyl N-(4-((2-(2,4-diamino-5-(2,3-dibromopropyl)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl)methyl)amino)-3-bromobenzoyl)glutamate  0   *Glutamates *Pyrimidines 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/antagonists & inhibitors. Anticancer Drugs 2008 Aug;19(7):697-704

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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