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Thalidomide

More information in Books or onNLM PubMed
Definition: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.     
Pharmacological Action Angiogenesis Inhibitors; Immunosuppressive Agents; Leprostatic Agents; Teratogens 		Other names Thalomid; Sedoval; Celgene Brand of ThalidomideDrugs* : THALOMID
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3,6'-dithiothalidomide  0   Thalidomide/*analogs & derivatives Tumor Necrosis Factor-alpha/antagonists & inhibitors. J Neurochem 2011 Sep;118(6):1032-42
5-hydroxythalidomide  0   Thalidomide/*analogs & derivatives. J Chromatogr B Biomed Appl 1995 Dec 15;674(2):287-92
DT PACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Dexamethasone Doxorubicin Etoposide Thalidomide. Blood Coagul Fibrinolysis 2009 Jul;20(5):337-9
1-O-methyl-2,3,4-tri-acetyl-6-tetrafluorophthalimido-6-deoxy-D-glucopyranose  0   *Glucosides Thalidomide/*analogs & derivatives. Acta Pharmacol Sin 2009 Jan;30(1):134-40
MDT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Melphalan Thalidomide. Int J Hematol 2007 Jul;86(1):69-71
5,N-dihydroxythalidomide  0   Thalidomide/*analogs & derivatives Tumor Necrosis Factor-alpha/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2006 Dec;54(12):1709-14
4-fluorothalidomide  0   Thalidomide/*analogs & derivatives Fluorine Radioisotopes. Nucl Med Biol 2006 Feb;33(2):255-62
apremilast  0   Thalidomide/*analogs & derivatives. Curr Opin Investig Drugs 2005 May;6(5):513-7
CPS 49  0   Thalidomide/*analogs & derivatives. Clin Cancer Res 2004 Jun 15;10(12 Pt 1):4192-7
CPS 45  0   Thalidomide/*analogs & derivatives. Clin Cancer Res 2004 Jun 15;10(12 Pt 1):4192-7
CPS 11  0   Thalidomide/*analogs & derivatives. Clin Cancer Res 2004 Jun 15;10(12 Pt 1):4192-7
TCID protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Thalidomide Idarubicin. Ann Hematol 2004 Jul;83(7):467-70
3-fluorothalidomide  0   Thalidomide/*analogs & derivatives. Oncol Res 2003;14(2):75-82
hyperCDT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Thalidomide. Br J Haematol 2003 Aug;122(4):607-16
SelCID-3  0   Thalidomide/*analogs & derivatives. Cancer Res 2003 Feb 1;63(3):593-9
DT-PACE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Etoposide Thalidomide. Leuk Lymphoma 2002 Jun;43(6):1267-71
lenalidomide  191732-72-6   Thalidomide/*analogs & derivatives.
Pharma Action Antineoplastic Agents 		Clin Exp Immunol 2002 Oct;130(1):75-84REVLIMID
pomalidomide  0   Thalidomide/*analogs & derivatives. Clin Exp Immunol 2002 Oct;130(1):75-84
3-aminophthalimidoglutarimide  19171-19-8   Thalidomide/*analogs & derivatives. Cancer Res 2002 Apr 15;62(8):2300-5
5'-hydroxythalidomide  0   Thalidomide/*analogs & derivatives. Ther Drug Monit 2002 Feb;24(1):104-10
CC 3052  0   Thalidomide/*analogs & derivatives. J Immunol 1998 Oct 15;161(8):4236-43
3'-methylthalidomide  0   *Thalidomide. Chem Pharm Bull (Tokyo) 1998 Jul;46(7):1165-8
N-phthalimidino glutaric acid  0   Thalidomide/*analogs & derivatives. Exp Eye Res 1997 Jun;64(6):971-8
2-(2-(3-azido-4-iodophenylpropionamido)ethoxy)thalidomide  0   *Azides Thalidomide/*analogs & derivatives Iodine Radioisotopes. Proc Natl Acad Sci U S A 1996 Jul 23;93(15):7552-6
tetrafluorothalidomide  0   Thalidomide/*analogs & derivatives Tumor Necrosis Factor-alpha/antagonists & inhibitors. J Med Chem 1996 Aug 2;39(16):3044-5
phthalimidophthalimide  4388-29-8   Thalidomide/*analogs & derivatives. Arch Toxicol 1994;68(3):203-5
N-hydroxythalidomide  126663-38-5   Thalidomide/*analogs & derivatives. Arzneimittelforschung 1989;39(3):293
EM 16  26581-91-9   Thalidomide/*analogs & derivatives. J Chromatogr 1989;488(2):417
EM 240  75871-97-5 Benzoic acid, 2-(((2-oxo-3-piperidinyl)amino)sulfonyl)  Thalidomide/*analogs & derivatives. Teratology 1980;22(2):183
supidimide  49785-74-2   Thalidomide/*analogs & derivatives. Teratology 1980;22(2):179
N-phthalylisoglutamine  2614-08-6   Thalidomide/*analogs & derivatives. Arch Toxicol 35(1):63;1976
K 2004-1c  58958-06-8 2-(bicyclo(2.2.1)heptane-2-endo-3-endo- dicarboximido)glutaramide  Thalidomide/*analogs & derivatives. Arch Toxicol 35(1):63;1976
biglumide  14166-26-8 2-(2,6-dioxo-3-piperidinyl)hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione  Thalidomide/*analogs & derivatives. Arch Pharm (Weinheim) 309(8):609;1976; Arch Pharm (Weinheim) 311(9):779;1978; Arch Toxicol 35(1):63;1976; Arch Toxicol 37(2):165;1977; Arzneim Forsch 1979;29(7):1036; Arzneim Forsch 1979;29(8):1146; Arzneim Forsch 24(10):1616;1974
2-(2,6-dioxopiperidin-3-yl)phthalimidine  26581-81-7 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione  Thalidomide/*analogs & derivatives. Teratology 19(3):341;1979; Teratology 5(2):233;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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