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Thebaine

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Definition: A drug that is derived from opium, which contains from 0.3-1.5% thebaine depending on its origin. It produces strychnine-like convulsions rather than narcosis. It may be habit-forming and is a controlled substance (opiate) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). (From Merck Index, 11th ed)  thebaine derivatives   
Pharmacological Action Convulsants; Narcotics
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-aminomethyl-6,14-ethanotetrahydrooripavine  0   Thebaine/*analogs & derivatives Ligands. J Med Chem 2007 Oct 18;50(21):5176-82
7-aminomethyl-6,14-ethanotetrahydrothebaine  0   Thebaine/*analogs & derivatives Ligands. J Med Chem 2007 Oct 18;50(21):5176-82
7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydronorthebaine  0   Thebaine/*analogs & derivatives. Biopharm Drug Dispos 2004 Apr;25(3):117-26
N-cyclopropylmethyl-7-(1-hydroxy-1-methyl-3-(2-thiophene)propyl)-6,14-endoethanotetrahydrooripavine  0   Thebaine/*analogs & derivatives. Biopharm Drug Dispos 2004 Apr;25(3):117-26
bractazonine  0   Thebaine/*analogs & derivatives. J Org Chem 2003 Mar 7;68(5):1929-32
ASM 5-10  140164-88-1   4-Chloro-7-nitrobenzofurazan/*analogs & derivatives Sarcosine/*analogs & derivatives Thebaine/*analogs & derivatives. Biochem Pharmacol 1992 Jan 22;43(2):301-6
N-(cyclopropylmethyl)-6,14-endo-etheno-7-(3-carboxy-3-n-butenyl)tetrahydronororipavine gamma-lactone  127154-03-4   Thebaine/*analogs & derivatives. JMed Chem 1990;33(8):2286
RX 140M  14186-98-2 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-alpha,17-dimethyl-alpha-(3-methylbutyl)-, (5alpha,7alpha(R))  Thebaine/*analogs & derivatives. Prog Clin Biol Res 1990;328:379
7-bis(beta-chloroethyl)aminomethyl-6,14-endoethenotetrahydrooripavine  114836-79-2   Thebaine/*analogs & derivatives. Chung Kuo Yao Li Hsueh Pao 1989;10(2):97
N-allyl-7-N,N-bis(beta-chloroethyl)amino-6,14-endoethenotetrahydronororipavine  123553-00-4   Thebaine/*analogs & derivatives Receptors, Opioid/drug effects. Sci China (B) 1989;32(3):335
7-(N,N-bis(2-chloroethyl)amino)-6,14-endoethenotetrahydrooripavine  94859-17-3   Thebaine/*analogs & derivatives Receptors, Opioid/drug effects. Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao 1987;9(2):118
NIH 10236  88167-37-7   Thebaine/*analogs & derivatives. Eur J Pharmacol 1986;126(3):313
hybromet  95461-73-7   *Organomercury Compounds Thebaine/*analogs & derivatives. J Med Chem 1985;28(12):1950
NIH 10364  95387-01-2   Thebaine/*analogs & derivatives. Neuropeptides 1984;5(1-3):229
endo-ethenotetrahydrooripavine  87453-63-2 6,14-Ethenomorphinan-3-ol, 7-amino-4,5-epoxy-6-methoxy-17-methyl-, (5alpha,7alpha)  Thebaine/*analogs & derivatives. Science 1983;220(4594):314
phi-dihydrothebaine  6878-93-9   Thebaine/*analogs & derivatives. Arch Int Pharmacodyn Ther 1981;254(2):223
dihydrothobainone  847-86-9   Thebaine/*analogs & derivatives. J Med Chem 19(10):1171;1976
oripavine  467-04-9   Thebaine/*analogs & derivatives. J Med Chem 18(11):1074;1975; J Med Chem 20(5):682;1977
drotebanol  3176-03-2 3,4-dimethoxy-17-methylmorphinan-6 beta,14-diol  Thebaine/*analogs & derivatives. Bull Narc 29(1):33;1977
N-cyclopropylmethyl oripavine  0   Thebaine/*analogs & derivatives Cyclopropanes Morphinans. Brit J Pharmacol 43(2):461P;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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