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Theophylline

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Definition: A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLATE CYCLASE and cyclic AMP.     
Pharmacological Action Bronchodilator Agents; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Vasodilator Agents 		Other names von ct, theo; ct, theo von; ct Arzneimittel Brand of Theophylline Sodium Glyci; Theophyllinate, Glycine; Theo24; Theo Dur; Theo 24; SomophyllinT; Somophyllin T; Sodium Glycinate, Theophylline; SloPhyllin; Slo Phyllin; Quibron TSR; Quibron T SR; Glycinate, Theophylline Sodium; ConstantT; Constant T; 1,3 Dimethylxanthine; theo von ct; ct-Arzneimittel Brand of Theophylline Sodium GlyciDrugs* : THEOPHYLLINE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER; THEOPHYLLINE 0.32% AND DEXTROSE 5% IN PLASTIC CONTAINER; SLO-PHYLLIN; THEOCLEAR-100; AQUAPHYLLIN; T-PHYL; AEROLATE SR; THEO-DUR; THEOCLEAR-200; THEOBID; THEOLAIR; LANOPHYLLIN; THEOCLEAR L.A.-130; THEOVENT; SOMOPHYLLIN-CRT; THEOPHYLLINE-SR; THEOLIXIR; THEOPHYL-225; SUSTAIRE; AEROLATE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
desethyletamiphylline  0   Theophylline/*analogs & derivatives. Drug Test Anal 2010 Jun;2(6):271-7
7-(2-(methacryloyloxy)ethylcarbamoyl)theophylline  0   Theophylline/*analogs & derivatives. Chem Pharm Bull (Tokyo) 2007 Mar;55(3):389-92
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dimethylxanthine  0   *Pyrazoles Theophylline/*analogs & derivatives Receptor, Adenosine A2B/antagonists & inhibitors. J Med Chem 2006 Jun 15;49(12):3682-92
8-(methylthio)theophylline  0   Theophylline/*analogs & derivatives. Inorg Chem. 2004 Feb 9;43(3):905-13
8-thiotheophylline  0   Theophylline/*analogs & derivatives. Inorg Chem. 2004 Feb 9;43(3):905-13
7-(2-mesyloxy-2-phenylethyl)theophylline  0   *Mesylates Theophylline/*analogs & derivatives. Nucleic Acids Res Suppl 2001:(1):27-8
bis(theophyllinato-N(7))bis(triphenylphosphine)platinum(II)  0   *Organoplatinum Compounds Theophylline/*analogs & derivatives. Acta Crystallogr C 2002 Feb;58(Pt 2):m111-5
7-2-2-(3,4-dihydroxy-phenyl-2-hydroxyethyl-aminoethyl)-theophylline  0   Theophylline/*analogs & derivatives Xanthines. Actas Luso Esp Neurol Psiquiatr Cienc Afines 1998; Sep-Oct;26(5):333-8
MED 27  104333-87-1   Theophylline/*analogs & derivatives Thromboxane-A Synthase/antagonists & inhibitors. Arzneimittelforschung 1996 Jan;46(1):35-41
theophylline, salbutamol drug combination  0   *Albuterol *Theophylline Drug Combinations. Ter Arkh 1995;67(6):26-9
8-aminotheophylline-7-butyric acid  0   Theophylline/*analogs & derivatives. Acta Pol Pharm 1994;51(4-5):385-91
guarana powder  0   *Caffeine *Theobromine *Theophylline Sapindaceae. Analyst 1994 Dec;119(12):2701-3
mepifiline  57383-74-1   Pyrilamine/*analogs & derivatives Theophylline/*analogs & derivatives. Allergol Immunopathol (Madr) 1994 Jan-Feb;22(1):3-8
7-(1,3-thiazolidin-2-ylmethyl)theophylline  103814-80-8 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-thiazolidinylmethyl)  *Thiazolidines Theophylline/*analogs & derivatives. Drug Metab Dispos Biol Fate Chem 1992 Sep-Oct;20(5):742-6
ambroxol-theophylline-7-acetate  0   Ambroxol/*analogs & derivatives Theophylline/*analogs & derivatives. Int J Tissue React 1992;14(1):31-6
etheofazine  85609-79-6 1H-Purine-2,6-dione, 8-(3,3-dimethyl-1-triazenyl)-7-ethyl-3,7-dihydro-1,3-dimethyl  Theophylline/*analogs & derivatives Biotransformation. Yao Hsueh Hsueh Pao 1992;27(3):166-9
7-(3-deoxy-3-fluorohex-2-enopyranosyl-4-ulose)theophylline  142270-03-9   Theophylline/*analogs & derivatives. Carbohydr Res 1992 Apr 10;228(1):95-102
7-(4'-(2-nitroimidazole-1-yl)butyl)theophylline  137046-51-6   *Nitroimidazoles Theophylline/*analogs & derivatives. Int J Radiat Biol 1992 Jun;61(6):797-804
6-(7-theophylline)-3(2H)-pyridazinone  139026-57-6   *Pyridazines Theophylline/*analogs & derivatives. Arch Pharm (Weinheim) 1991 Dec;324(12):999-1001
7-(2-(1-methyl-2-phenyl-ethylamino)propyl)theophylline  133563-07-2   Theophylline/*analogs & derivatives. Arch Pharm (Weinheim) 1991 Sep;324(9):543-6
pamabrom  606-04-2   *Propanolamines Drug Combinations Theophylline/*analogs & derivatives. Cleve Clin J Med 1991;58(1):33
8-thiotheophyllinate-triphenylphosphine gold(I)  137025-15-1   *Organophosphorus Compounds *Organogold Compounds Theophylline/*analogs & derivatives Gold. Anticancer Res 1991;11(2):625
ABC 99  116763-36-1 1H-Purine-2,6-dione, 7-(1,3-dithiolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl  Theophylline/*analogs & derivatives. Drugs Exp Clin Res 1990;16(6):263
theophylline-rutozide  0   *Theophylline Drug Combinations Rutin/*analogs & derivatives. Rev Med Chir Soc Med Nat Iasi 1990;94(1):151
CHINOIN 170  88338-63-0   *Oxadiazoles Theophylline/*analogs & derivatives. Acta Pharm Hung 1989;59 suppl 1:32
8-(3-sulfophenyl)theophylline  129107-78-4   Theophylline/*analogs & derivatives. Naunyn Schmiedebergs Arch Pharmacol 1990;341(5):445
imfilin  106131-93-5   Theophylline/*analogs & derivatives. Rev Med Chir Soc Med Nat Iasi 1989;93(3):577
carprofilin  101706-05-2   Theophylline/*analogs & derivatives. Rev Med Chir Soc Med Nat Iasi 1989;93(3):577
7-(2-(1-hydroxy-2-butylamino)ethyl)theophylline  108940-62-1   Theophylline/*analogs & derivatives. Acta Crystallogr C 1988;44(Pt 7):1235
Ersilan  135556-19-3   *Dihydroergotoxine Drug Combinations Theophylline/*analogs & derivatives. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralov 1988;31(5 Suppl):649
7-gamma-(beta-hydroxypropyl)theophylline 2',4'-dichlorobenzoate  117782-63-5   Theophylline/*analogs & derivatives. Acta Pol Pharm 1988;45(4):362
teomorfolin  100706-81-8   *Morpholines Theophylline/*analogs & derivatives. Drugs Exp Clin Res 1988;14(5):347
7-(2-chloroethyl)theophylline  5878-61-5   Theophylline/*analogs & derivatives. Pharmacol Biochem Behav 1988;30(1):155
8-cyclopropyltheophylline  35873-47-3   Theophylline/*analogs & derivatives. Psychopharmacology 1988;94(3):417
Jupal  2530-97-4   Theophylline/*analogs & derivatives. Z Arztl Fortbild (Jena) 1987;81(17):879
8-cyclopentyl-1,3-dimethylxanthine  35873-49-5   Theophylline/*analogs & derivatives.
Pharma Action Purinergic P1 Receptor Antagonists 		Brain Res 1987;417(2):377
phthalidyltheophylline  107745-64-2   Theophylline/*analogs & derivatives. J Pharmacobiodyn 1987;10(1):15
7-(3,4-dideoxy-6-O-(6-hydroxyhexyl)hex-3-enopyranosyl-2-ulose)theophylline  107838-98-2   *Nucleosides Theophylline/*analogs & derivatives. Carbohydr Res 1986;156:256
7-(6-O-(5-carboxypentyl)-3,4-dideoxyhex-3-enopyranosyl-2-ulose)theophylline  107838-94-8   *Nucleosides Theophylline/*analogs & derivatives. Carbohydr Res 1986;156:256
furafylline  80288-49-9   Theophylline/*analogs & derivatives Cytochrome P-450 CYP1A2/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Pharm Pharmacol 1986;38(8):615
perphyllon  8066-99-7   *Atropine Derivatives *Papaverine *Phenobarbital *Theophylline Drug Combinations. Wien Med Wochenschr 1986;136(9):213
deriphyllin-digoxin  0   *Digoxin Drug Combinations Theophylline/*analogs & derivatives Delayed-Action Preparations. Int J Clin Pharmacol Ther Toxicol 1986;24(1):30
tazifylline  79712-55-3   Theophylline/*analogs & derivatives. Eur J Clin Pharmacol 1986;30(1):27
BY 118K  0   *Theophylline Delayed-Action Preparations. Prax Klin Pneumol 1984;38(5):182
pulmophylline (new)  95646-60-9 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1), mixt. with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione  *Theophylline. Z Ekr Atmungsorgane 1984;62(1):18
pulmophylline  8059-07-2   *Antipyrine *Theophylline Drug Combinations. Z Erkr Atmungsorgane 1984;162(1):18
flufylline  82190-91-8   Theophylline/*analogs & derivatives. Arzneimittelforsch 1984;34(1):1
fluprophylline  85118-43-0 1H-Purine-2,6-dione, 7-(3-(4-(4-fluorobenzoyl)-1-piperidinyl)propyl)-3,7-dihydro-1,3-dimethyl  Theophylline/*analogs & derivatives. Arzneimittelforsch 1984;34(1):1
AC 85  80296-66-8   Theophylline/*analogs & derivatives. J Chromatogr 1983;277:239
AC 119  80296-67-9   Theophylline/*analogs & derivatives. J Chromatogr 1983;277:239
AC 155  80296-68-0   Theophylline/*analogs & derivatives. J Chromatogr 1983;277:239
6-thiotheophylline  2398-70-1   Theophylline/*analogs & derivatives. Pharmacol Res Commun 1983;15(2):131
lysine theophylline  83920-54-1   Theophylline/*analogs & derivatives. Postgrad Med J 1983;59(688):86
Eucebral-N  84930-23-4 Benzeneacetic acid, alpha-hydroxy-, 3,3,5-trimethylcyclohexyl ester, mixt. with 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione  *Cyclandelate Drug Combinations Theophylline/*analogs & derivatives Cerebrovascular Disorders/drug therapy. Arzneimittelforsch 1982;32(10):1322
drotaverine, acephyllinate drug combination  61954-97-0   Drug Combinations Papaverine/*analogs & derivatives Theophylline/*analogs & derivatives. Acta Vet Acad Sci Hung 1981;29(2):173
theophylline-7-acetylaminobutanol  82951-56-2 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-N-(1-(hydroxymethyl)propyl)-1,3-dimethyl-2,6-dioxo  Theophylline/*analogs & derivatives. Ann Acad Med Stetin 1981;27:297
beta-galactosylumbelliferone theophylline  79181-90-1 2H-1-Benzopyran-3-carboxamide, 7-(beta-D-galactopyranosyloxy)-2-oxo-N-(3-(2,3,6,7-tetrahydro-1,3-dimethyl-2,6-dioxo-1H-purin-8-yl)propyl)  Theophylline/*analogs & derivatives. Clin Chem 1981;27(9):1614
lomifylline  10226-54-7   Theophylline/*analogs & derivatives. Eur Neurol 1981;20(3):265
8-(4-sulfophenyl)theophylline  80206-91-3 Benzenesulfonic acid, 4-(2,3,6,7-tetrahydro-1,3-dimethyl-2,6-dioxo-1H-purin-8-yl)  Theophylline/*analogs & derivatives.
Pharma Action Purinergic P1 Receptor Antagonists 		Life Sci 1981;28(23):2611
theophylline olamine  573-41-1   *Ethanolamines *Theophylline. J Pharm Sci 1981;70(6):589
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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