encyclopedia of medical concepts
ψ 
ψ 

Thiadiazoles

More information in Books or onNLM PubMed
Definition:   includes thiadiazolines, thiadiazolidines   
Examples Acetazolamide; Benzolamide; Methazolamide; Timolol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
O-ethyl S-(5-(5-(tert-butyl)-2-oxo-1,3,4-thiadiazol-3(2H)-yl)-6-fluorobenzo-thiazol-2-yl)carbonothioate  0   *Thiadiazoles. Bioorg Med Chem. 2012 Jan 1;20(1):296-304
3-pyridin-4-yl-6-(thiophen-2-ylmethyl)-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazole  0   *Thiadiazoles *Triazoles. Chem Biol. 2011 Dec 23;18(12):1658-68.
6-(3,4-dimethoxyphenyl)-3-pyridin-2-yl-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazole  0   *Thiadiazoles *Triazoles. Chem Biol. 2011 Dec 23;18(12):1658-68.
6-cyclohexyl-3-furan-2-yl-(1,2,4)triazolo(3,4-b)(1,3,4)thiadiazole  0   *Thiadiazoles *Triazoles. Chem Biol. 2011 Dec 23;18(12):1658-68.
4-chloro-N-(5-(((2-chloroquinolin-3-yl)methyl)thio)-1,3,4-thiadiazol-2-yl)benzamide  0   *Quinolines *Thiadiazoles Anticonvulsants. Chem Biol Drug Des. 2012 Jan;79(1):104-11
N-(5-(((2-chloroquinolin-3-yl)methyl)thio)-1,3,4-thiadiazol-2-yl)-4-methylbenzamide  0   *Quinolines *Thiadiazoles Anticonvulsants. Chem Biol Drug Des. 2012 Jan;79(1):104-11
N-((4-fluorophenyl)(1-methyl-1H-imidazol-2-yl)methyl)-2-methyl-3-(1,2,4-thiadiazol-5-yl)-1H-indole-6-carboxamide  0   *Indoles *Thiadiazoles IMP Dehydrogenase/antagonists & inhibitors. Eur J Pharmacol. 2012 Jan 5;674(1):58-63.
2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole  0   *Thiadiazoles Antineoplastic Agents. Folia Histochem Cytobiol. 2011;49(3):436-44
2,5-dimercapto-1,3,5-thiadiazole  0   *Thiadiazoles. Langmuir. 2011 Nov 15;27(22):13904-9
1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one  0   *Spiro Compounds *Thiadiazoles. J Biol Chem. 2011 Nov 4;286(44):38000-17.
5-2-(4-((ethylmethylamino)carbonyl)-3-fluorophenyl)-alpha,alpha-dimethyl-N-1,3,4-thiadiazol-2-yl-5H-(1)benzopyrano(2,3-b)pyridin-5-acetamide  0   *Heterocyclic Compounds, 3-Ring *Thiadiazoles. J Med Chem. 2011 Oct 27;54(20):7318-33.
2-(4-((dimethylamino)carbonyl)-3-fluorophenyl)-alpha,alpha-dimethyl-N-1,3,4-thiadiazol-2-yl-5H-(1)benzopyrano(2,3-b)pyridin-5-acetamide  0   *Heterocyclic Compounds, 3-Ring *Thiadiazoles. J Med Chem. 2011 Oct 27;54(20):7318-33.
1-(2-fluorophenyl)-3-(2-(morpholin-2-yl)ethyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide  0   *Cyclic S-Oxides *Thiadiazoles Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors. J Med Chem. 2011 Oct 13;54(19):6824-31.
3-(2-methoxy-1-methylethoxy)-5-(4-methylsulfonylphenoxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzamide  0   *Sulfones *Thiadiazoles Enzyme Activators. J Mol Endocrinol 2011;47(1):59-67
N-propyl-4-(4-(5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl)piperazin-1-yl)benzamidine  0   *Benzamidines *Thiadiazoles. Eur J Med Chem 2011 Jun;46(6):2602-8
2-benzyl-5-thiocyanato-6-(4'-fluorophenyl)imidazo(2,1-b)(1,3,4)thiadiazole  0   *Imidazoles *Thiadiazoles. Eur J Med Chem 2011 Jun;46(6):2109-16
2-(5-(4-bromophenyl)-1-(2-chlorophenyl)-4-(methylsulfonyl)-1H-pyrazol-3-yl)-5-(1-(trifluoromethyl)cyclobutyl)-1,3,4-thiadiazole  0   *Pyrazoles *Thiadiazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Future Med Chem 2009 Aug;1(5):947-67
2-(1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-(methylsulfonyl)-1H-pyrazol-3-yl)-5-(1-(trifluoromethyl)cyclobutyl)-1,3,4-thiadiazole  0   *Pyrazoles *Thiadiazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Future Med Chem 2009 Aug;1(5):947-67
2-(nicotinamide)-1,3,4-thiadiazole  0   *Thiadiazoles Niacinamide/*analogs & derivatives Aquaporin 4/antagonists & inhibitors. Neurol Sci 2011 Feb;32(1):113-6
3,5-(3',3''-bisindolyl)-1,2,4-thiadiazole  0   *Indoles *Thiadiazoles. Phytochemistry. 2011 Feb;72(2-3):199-206
SCH 2047069  0   *Benzopyrans *Thiadiazoles. Mol Cancer Ther 2010 Nov;9(11):2993-3002
poly(2,6-(4,4-bis(2-ethylhexyl)-4H-cyclopenta(2,1-b-3,4-b0)dithiophene))-alt-4,7-(2,1,3-benzothiadiazole)  0   *Polymers *Thiadiazoles. Adv Mater 2010 Oct 8;22(38):4321-4
dithienylbenzobis(thiadiazole)  0   *Thiadiazoles. Chem Commun (Camb). 2010 May 21;46(19):3265-7
2,5-di-(2-pyridyl)-1,3,4-thiadiazole  0   *Thiadiazoles. Dalton Trans. 2010 Feb 21;39(7):1689-91
UK-414,495  0   *Pentanoic Acids *Thiadiazoles. Br J Pharmacol. 2010 May;160(1)48-50
4-(3-(2-fluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl)-1-(methylamino)butan-2-ol  0   *Cyclic S-Oxides *Thiadiazoles. J Med Chem 2010 Jun 10;53(11):4511-21
4-dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide  0   *Sulfonamides *Thiadiazoles Proto-Oncogene Proteins c-akt/antagonists & inhibitors. Mol Cancer Ther 2010 Mar;9(3):706-17
1,3,4-thiadiazolylmethylphenyl glucoside  0   *Glucosides *Thiadiazoles. Bioorg Med Chem. 2010 Mar 15;18(6):2178-94
MF 438  0   *Pyridazines *Thiadiazoles Stearoyl-CoA Desaturase/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Jan 15;20(2):499-502
1,2,4-triazolylmercaptomethyl-1,3,4-thiadiazole  0   *Thiadiazoles *Triazoles. J Enzyme Inhib Med Chem. 2010 Feb;25(1):126-31
4-carboxy-5-((4-chlorophenyl)sulfanyl)-1,2,3-thiadiazole  0   *Thiadiazoles. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Dec 1;65(Pt 12):1246-53
NP12  0   *Thiadiazoles Glycogen Synthase Kinase 3/antagonists & inhibitors. Neurobiol Dis. 2009 Sep;35(3):359-67
2-(tert-butyldithio)-5-methyl-,3,4-thiadiazole  0   *Thiadiazoles. Phys Chem Chem Phys. 2005 Mar 7;7(5):731-7
poly(2,7-(9,9-di-n-octylfluorene)-co-4,7-(2,1,3-benzothiadiazole))  0   *Fluorenes *Thiadiazoles Polymers. J Chem Phys 2009 Jul 21;131(3):035104
ARRY 520  0   *Thiadiazoles. J Transl Med 2009;7:63
N-(2-chloropyridin-3-yl)-2-(4-(2,4-dibromophenyl)-1,2,3-thiadiazol-5-ylthio)acetamide  0   *Acetamides *Thiadiazoles. Bioorg Med Chem. 2009 Aug 15;17(16):5920-7
N-(3-oxo-3-(4-(pyridin-4-yl)piperazin-1-yl)propyl)benzo(c)(1,2,5)thiadiazole-4-sulfonamide  0   *Sulfonamides *Thiadiazoles Receptor, Muscarinic M1/antagonists & inhibitors. Mol Pharmacol 2009 Aug;76(2):356-68
K 858  0   *Thiadiazoles. Cancer Res 2009 May 1;69(9):3901-9
2',3',4',5,5',6,7,8,9,10-decahydro-2-(5-(4-fluorophenyl)-1-methylpyrazol-3-yl)-5'-(2,2,2-trifluoroethyl)spiro(6,9-methanobenzocycloocten-11,3'-(1,2,5)thiadiazole) 1',1'-dioxide  0   *Thiadiazoles *Cyclooctanes Amyloid Precursor Protein Secretases/antagonists & inhibitors. J Med Chem 2009 Jun 11;52(11):3441-4
N-(5-(4-methoxybenzyl)-1,3,4-thiadiazol-2-yl)benzenesulfonamide  0   *Sulfonamides *Thiadiazoles gamma-Glutamyltransferase/antagonists & inhibitors. J Biol Chem 2009 Apr 3;284(14):9059-65
5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine  0   *Thiadiazoles JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):1943-52
1,3,4-thiadiazolium-2-aminide  0   *Thiadiazoles. Antimicrob Agents Chemother 2009 Feb;53(2):839-42
bismerthlazol  0   *Thiadiazoles. Sichuan Da Xue Xue Bao Yi Xue Ban 2008 Mar;39(2):247-9
polythiocyanogen  0   *Polymers *Thiadiazoles. Dalton Trans 2008 Dec 28;(48):6925-32
4-(3-phenyl-(1,2,4)-thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide  0   *Piperazines *Thiadiazoles. Anesth Analg 2009 Jan;108(1):316-29
3-(3-(3-florophenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6- tetrahydro-1-methylpyridine oxalate  0   *Pyridines *Thiadiazoles. Neurosci Bull 2008 Aug;24(4):251-7
3-(3-(3-trifluoropropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine  0   *Pyridines *Thiadiazoles Carbon Radioisotopes. Nucl Med Biol 2008 Apr;35(3):287-98
NP00111  0   *Thiadiazoles. Exp Neurol 2008 Jul;212(1):93-9
2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid  0   *Thiadiazoles Alanine/*analogs & derivatives. J Med Chem 2008 Mar 13;51(5):1459-63
7-(5-ethyl-1,3,4-thiadiazol-2-yl)-9-propyl-7-azaspiro(4,5)decane-6,8-dione  0   *Piperidones *Thiadiazoles. J Med Chem 2007 Nov 29;50(24):6165-76
1,3,4-thiadiazole-2-thione  0   *Thiadiazoles *Thiones. Bioorg Med Chem. 2007 Nov 15;15(22):6975-84
bismuthiol II  0   *Thiadiazoles. Ann Chim 2007 Jan-Feb;97(1-2):109-21
5-(4-chlorophenyl)-3-(2,4,6-trifluorophenyl)-2,3-dihydro-2-(2,3-dimethoxyphenyl)-1,3,4-thiadiazole  0   *Thiadiazoles. J Med Chem 2007 Aug 23;50(17):4255-9
MRK 003  0   *Cyclic S-Oxides *Thiadiazoles Amyloid Precursor Protein Secretases/antagonists & inhibitors. Chem Biol 2007 Feb;14(2):209-19
bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide  0   *Sulfides *Thiadiazoles Glutaminase/antagonists & inhibitors. Biochem J 2007 Sep 15;406(3):407-14
5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole  0   *Thiadiazoles. Bioorg Med Chem 2007 Jun 15;15(12):3981-9
fluoroxanomeline  0   *Thiadiazoles Fluorine Radioisotopes Receptor, Muscarinic M1/agonists. Nucl Med Biol 2007 Feb;34(2):141-52
NP 031112  0   *Thiadiazoles. J Neurosci 2007 May 23;27(21):5766-76
4-(5-(3-hydroxycyclohexylimino)-4-methyl-4,5-dihydro-(1,3,4)thiadiazol-2-yl)benzamide  0   *Benzamides *Thiadiazoles. Pulm Pharmacol Ther 2007;20(1):60-8
dimercaptothiadiazole  0   *Thiadiazoles. Anal Biochem. 2006 Oct 15;357(2):188-93
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy