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Thiazepines

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Definition:      
Examples Dibenzothiazepines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
S107 compound  0   *Thiazepines. J Mass Spectrom. 2011 Feb;46(2):112-30
5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-2,3,6,7-tetrahydro-1,4-thiazepine  0   *Pyrans *Thiazepines. Pharmazie. 2011 Feb;66(2):98-104
(E)-3-(2-(thiophene-2-yl)-2,3-dihydrobenzo(b)(1,4)thiazepin-4-yl)phenol  0   *Thiazepines. Theor Biol Med Model. 2010;7() (dup#17):22
rac-5-formyl-2,2,4-trimethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine  0   *Thiazepines. Acta Crystallogr C. 2009 Nov;65(Pt 11):o579-82
rac-5-diphenylacetyl-2,2,4-trimethyl-2,3,4,5-tetrahydro-1,5-benzothiazepine  0   *Thiazepines. Acta Crystallogr C. 2009 Nov;65(Pt 11):o579-82
S-107 compound  0   *Thiazepines. Rapid Commun Mass Spectrom 2009 Apr;23(8):1139-46
1,4-bis(dibenzo(b,f)(1,4)thiazpein-11-yl)piperazine  0   *Piperazines *Thiazepines. Pharm Dev Technol 2009;14(1):27-37
11-(3-chloro-4-fluorophenyl)dibenzo(b,f)(1,4)thiazepine-8-carboxylic acid butylamide  0   *Thiazepines Receptor, Cannabinoid, CB1/agonists. J Med Chem 2009 Apr 9;52(7):1975-82
9-piperazin-1-ylpyrrolo(2,1-b)benzothiazepine  0   *Piperazines *Pyrroles *Thiazepines. Int J Neuropsychopharmacol 2008 May;11(3):309-19
4-(2-dimethylaminoethyl)-4,5,6,7-tetrahydro-7-(4-methoxyphenyl)-5-oxothieno(2,3-b)(1,4)thiazepin-6-yl acetate  0   *Thiazepines *Thiophenes. Arzneimittelforschung 2007;57(12):757-61
benzimidazolo(2,1-b)benzo(e)thiazepin-5(10H)-one  0   *Benzimidazoles *Thiazepines. Arch Pharm (Weinheim). 2008 Jan;341(1):49-54
tetrahydroquino(7,8-b)(1,4)benzothiazepine  0   *Quinolines *Thiazepines. Molecules 2007;12(8):1558-68
2,8-dioxohexahydro(1,4)thiazepino(2,3-h)quinoline  0   *Thiazepines *Quinolones. Molecules 2007;12(8):1558-68
discorhabdin W  0   *Quinones *Spiro Compounds *Thiazepines. J Nat Prod 2005 Dec;68(12):1796-8
1-(4-methoxyphenylethyl)-6-methylbenzo(c)-1,2-dihydropyrido(2,3-f)(1,2,5)thiadiazepine 5,5-dioxide  0   *Cyclic S-Oxides *Thiazepines. J Med Chem 2005 Nov 17;48(23):7363-73
FR255031  0   *Thiazepines. Br J Pharmacol 2005 Jan;144(1):133-43
9-(4-methylpiperazin-1-yl)pyrrolo(2,1-b)benzothiazepine  0   *Pyrroles *Thiazepines Receptors, Dopamine D2/antagonists & inhibitors Receptor, Serotonin, 5-HT2A/antagonists & inhibitors. J Med Chem 2004 Jan 1;47(1):143-57
discorhabdin A  0   *Quinones *Thiazepines. Angew Chem Int Ed Engl 2002 Jan 18;41(2):348-50
PR835  0   *Thiazepines. FASEB J 2003 Feb;17(2):265-7
discorhabdin R  0   *Quinones *Spiro Compounds *Thiazepines. J Nat Prod 2000 Nov;63(11):1527-8
3,7-dicarboxy-10,11-dihydroxy-2,3,4,5,6,7,8,9-octahydropyrido(4,3-g)(1,4)benzothiazepine  0   *Thiazepines. J Org Chem 2000 Jul 14;65(14):4269-73
JMV 1640  0   *Oligopeptides *Thiazepines Receptors, Bradykinin/antagonists & inhibitors. J Med Chem 2000 Jun 15;43(12):2387-94
N-hydroxy-4-((4--methoxyphenyl)sulfonyl)-2,2-dimethylhexahydro-1,4-thiazepine-3-carboxamide 1,1-dioxide  0   *Cyclic S-Oxides *Thiazepines Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4547-62
N-hydroxy-4-((4-methoxyphenyl)sulfonyl)-2,2-dimethylhexahydro-1,4-thiazepine-3-carboxamide  0   *Thiazepines Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4547-62
1,13a-dihydro-3H,5H,13H-naphtho(2,3-f)thiazolo(4,3-c)(1,4)thiazepine-5,13-dione  0   *Thiazepines *Thiazolidinediones. J Med Chen 1999 Aug 26;42(17):3334-41
2,3-dihydro-5H-naphtho(2,3-f)thiazolo(2,3-c)(1,4)thiazepine-5,13(1aH)-dione  0   *Thiazepines *Thiazolidinediones. J Med Chem 1999 Aaug 26;42(17):3334-41
2169W 94  0   *Thiazepines. Drug Metb Dispos 1999 Jun;27(6):637-44
264W 94  0   *Thiazepines. Drug Metab Dispos 1999 Jun;27(6):637-44
discorhabdin-Q  0   *Quinones *Spiro Compounds *Thiazepines. J Nat Prod 1999 Apr;62(4):636-7
1-(N-(2-(3,4-dimethoxyphenyl)-ethyl)-N-methylaminopropionyl)-1,2,3,4-tetrahydropyrido(2,3-b)(1,4)thiazepine  0   *Pyridines *Thiazepines. Biol Pharm Bull 1999 Jan;22(1):31-6
1-(N-(2-(3,4-dimethoxyphenyl)ethyl)-N-methylaminoacetyl)-1,2,3,4-tetrahydropyrido(2,3-b)(1,4)thiazepine  0   *Pyridines *Thiazepines. Biol Pharm Bull 1999 Jan;22(1):31-6
discorhabdin P  0   *Quinones *Spiro Compounds *Thiazepines. J Nat Prod 1999 Jan;62(1):173-5
7-chloro-9-(4-methylpiperazin-1-yl)-9,10-dihydropyrrolo(2,1-b)(1,3)benzothiazepine  0   *Pyrroles *Thiazepines. J Med Chem 1998 Sep 24;41(20):3763-72
MDL 201307  0   *Thiazepines. J Exp Ther Oncol 1996 Mar;1(2):109-18
K201 compound  0   *Thiazepines. Biochim Biophys Acta 1997 Nov 13;1330(1):1-7
1,5-benzothiazepine  0   *Thiazepines. Mol Pharmacol 1997 Feb;51(2):262-8
omapatrilat  0   *Pyridines *Thiazepines Metalloendopeptidases/antagonists & inhibitors.
Pharma Action Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Cardiovascular Agents ; Protease Inhibitors 		J Med Chem 1997 May 23;40(11):1570-7
10-(4-methylpiperazin-1-yl)pyrido(4,3-b)(1,4)benzothiazepine  136772-40-2   *Thiazepines. Eur J Pharmacol 1996 Aug 22;310(1):9-12
7-acetoxy-2-chloro-6,7-dihydro-10-((N,N-dimethylamino)methyl)-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine  0   *Pyrroles *Thiazepines. J Med Chem 1996 Jul 19;39(15):2922-38
2164U90  0   *Thiazepines. J Lipid Res 1995 May;36(5):1098-105
CGP 37157  75450-34-9   *Thiazepines Clonazepam/*analogs & derivatives. J Biol Chem 1993 Jan 15;268(2):938-47
4-(2-chlorodibenzo(bf)(1,4)thiazepin-11-yl)piperazine  5747-63-7   *Piperazines *Thiazepines. Yakugaku Zasshi 1992 Jul;112(7):479-88
RS 5773  129173-57-5   *Thiazepines. Arzneimittelforschung 1992 May;42(5):617-21
6-methyl-6,11-dihydro-11-((N,N-dimethylamino)acetyl)dibenzo(c,f)-(1,2,5)-thiadiazepine 5,5-dioxide  128377-70-8   *Thiazepines. Arzneimittelforschung 1991;41(6):573
KT2 230  134296-41-6 1,5-Benzothiazepine, 2,3,4,5-tetrahydro-5-(3-((2-(3-methylphenoxy)ethyl)amino)-1-oxopropyl)-, (E)-2-butenedioate (1:1)  *Thiazepines. Gen Pharmacol 1991;22(3):443
temocaprilat  110221-53-9   *Thiazepines. J Immunoassay 1991;12(1):15
7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine  131403-76-4   *Pyrroles *Thiazepines. Farmaco 1990;45(5):545
6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepin-7(6H)-ol  131403-79-7   *Pyrroles *Thiazepines. Farmaco 1990;45(5):545
tianeptine MC(5)  104732-22-1   *Thiazepines. Eur J Drug Metab Pharmacokinet 1990;15(1):69
naltiazem  108383-95-5   *Thiazepines. Biomed Environ Mass Spectrom 1989;18(11):978
8-amino-10,11-dihydrodibenzo(b,e)1,4-thiazepin-11-one  105554-89-0   *Thiazepines. Pharmazie 1989;44(4):265
azidodiltiazem  124255-99-8   *Azides *Thiazepines. Ann N Y Acad Sci 1989;560:198
temocapril hydrochloride  110221-44-8 1,4-Thiazepine-4(5H)-acetic acid, 6-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S-(2alpha,6beta(R*)))  *Thiazepines.
Pharma Action Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents 		Biochem Biophys Res Commun 1988;152(1):456
CV 5975  100277-62-1   *Thiazepines. Chem Pharm Bull (Tokyo) 1987;35(6):2319
BTM 1073  107784-01-0 Piperazinium, 1-butyl-1-methyl-4-((2,3,4,5-tetrahydro-4-oxo-2-phenyl-1,5-benzothiazepin-3-yl)methyl)-, bromide, cis  *Thiazepines. Gen Pharmacol 1987;18(1):91
KT 362  105394-80-7 1,5-Benzothiazepine, 5-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)-1-oxopropyl)-2,3,4,5-tetrahydro-, (E)-2-butenedioate (1:1)  *Thiazepines.
Pharma Action Anti-Arrhythmia Agents ; Calcium Channel Blockers ; Vasodilator Agents 		J Pharmacol Exp Ther 1987;240(1):16
tianeptine  66981-73-5   *Thiazepines Analgesics.
Pharma Action Antidepressive Agents, Tricyclic 		J Chromatogr 1986;381(1):115
CGS 10746B  81382-52-7   *Thiazepines. Life Sci 1986;39(8):699
BTM 1042  72293-40-4   *Thiazepines. Jpn J Pharmacol 1980;30(5):647
perhydro-1,4-thiazepine-3,5-dicarboxylic acid  56217-96-0 1,4-Thiazepine-3,5-dicarboxylic acid, hexahydro  *Thiazepines. Physiol Chem Phys 7(2):147;1975
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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