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Thioguanine

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Definition: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.     
Pharmacological Action Antimetabolites, Antineoplastic 		Other names 6-Thioguanine; Tioguanine GlaxoSmithKline Brand; ThioguaninGSK; Thioguanin GSK; 2 Amino 6 Purinethiol; 6 Thioguanine; Wellcome Brand of Thioguanine; Tioguanine; Tioguanina Wellcome; Thioguanine Tabloid; Thioguanine Monosodium Salt; Thioguanine Hemihydrate; Thioguanin-GSK; Tabloid; Lanvis; GlaxoSmithKline Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; Glaxo Wellcome Brand of Thioguanine; 2-Amino-6-PurinethiolDrugs* : THIOGUANINE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-9-(2-(phosphonomethoxy)ethyl)-6-sulfanylpurine  0   Thioguanine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2008;(52):671-2
N2,3-etheno-6-thioguanine  0   Thioguanine/*analogs & derivatives. J Chromatogr B Analyt Technol Biomed Life Sci 2008 Mar 15;864(1-2):149-55
guanine-6-thioguanine  0   Guanine/*analogs & derivatives Thioguanine/*analogs & derivatives. DNA Repair (Amst) 2007 Mar 1;6(3):344-54
POG-8498 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Azacitidine Cytarabine Daunorubicin Etoposide Methotrexate Prednisone Thioguanine Vincristine 6-Mercaptopurine. Pediatr Blood Cancer 2007 Mar;48(3):262-7
NSC35866  0   Thioguanine/*analogs & derivatives. Cancer Res 2005 Aug 15;65(16):7462-9
Berlin-Frankfurt-Muenster protocol II  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Thioguanine Vincristine. Blood 2002 Jul 15;100(2):420-6
TGAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Polyethylene Glycols Thioguanine. Cancer Chemother Pharmacol 2001 Aug;48(2):123-33
TPDCV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Lomustine Mitolactol Procarbazine Thioguanine Vincristine. Neuro-oncol 2000 Jan;2(1):22-8
8-hydroxythioguanine  0   Thioguanine/*analogs & derivatives. J Pharmacol Exp Ther 1999 Nov;291(2):870-4
TPDC-FuHu protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Hydroxyurea Lomustine Mitolactol Procarbazine Thioguanine. J Clin Oncol 1997 Mar;15(3):1063-70
DAT-COAP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Daunorubicin Prednisone Thioguanine Vincristine. Leuk Res 1996 Nov-Dec;20(11-12):987-8
BF-9 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Etoposide Mitoxantrone Thioguanine. Eur J Obstet Gynecol Reprod Biol 1995 Dec;63(2):139-41
DCTER protocol  0   Etoposide *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Dexamethasone Thioguanine. Blood 1996 Jun 15;87(12):4979-89
HR-2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Dexamethasone Ifosfamide Methotrexate Prednisolone Thioguanine Vindesine. Blood 1996 Apr 15;87(8):3143-50
ETI protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Thioguanine Idarubicin. Leukemia 1994 Jan;8(1):11-5
HATP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Harringtonines Prednisone Thioguanine. Chung Hua Nei Ko Tsa Chih 1993 Jul;32(7):470-2
PACET protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Lomustine Prednisolone Thioguanine. Eur J Cancer 1993;29A(2):190-2
DATV regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Thioguanine Vincristine. Chung Hua Nei Ko Tsa Chih 1992 Mar;31(3):146-8
VATA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Etoposide Thioguanine. Sangre (Barc) 1991 Oct;36(5):427-30
6-thioguainine disulfide  90920-73-3   Thioguanine/*analogs & derivatives. Biochem J 1991;275(Pt 1):29
LSA(2)L(2) protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Doxorubicin Prednisone Thioguanine Vincristine. Cancer Genet Cytogenet 1990;50(1):31
CART protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Daunorubicin Thioguanine. Pediatr Hematol Oncol 1986;3(1):1
HAT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Harringtonines Thioguanine. Chung Hua Nei Ko Tsa Chih 1990;29(1):22
D(A)AT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Doxorubicin Thioguanine. Chung Hua Nei Ko Tsa Chih 1990;29(1):22
6-(decyldithio)-1H-purin-2-amine  78263-87-3   Thioguanine/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Biochem Pharmacol 1990;39(9):1484
6-(phenyldithio)-1H-purin-2-amine  2959-10-6   Thioguanine/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Biochem Pharmacol 1990;39(9):1484
MI-MIV maintenance protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Thioguanine. Hamatol Bluttransfus 1990;33:261
PATCO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Prednisolone Thioguanine Vincristine. Cancer 1989;63(8):1457
ATA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Amsacrine Cytarabine Thioguanine. Cancer Chemother Pharmacol 1988;21(1):68
6-thio-3-deazaguanine  52605-85-3   Thioguanine/*analogs & derivatives. Cancer Res 1987;47(7):1863
BFM 78 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Doxorubicin Methotrexate Prednisone Thioguanine Vincristine. Med Oncol Tumor Pharmacother 1985;2(1):17
POCAL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Prednisolone Thioguanine Vincristine. Scand J Haematol 1986;37(2):130
New York protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Methotrexate Prednisone Thioguanine Vincristine. J Clin Oncol 1986;4(5):744
HOAGP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Harringtonines Prednisone Thioguanine Vincristine. Chung Hua I Hsueh Tsa Chih 1985;65(10):590
9-(n-butyl)-6-thioguanine  30546-08-8   Thioguanine/*analogs & derivatives. Cancer Res 1986;46(1):137
DATOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Prednisone Thioguanine Vincristine. Sangre (Barc) 1984;29(6):987
RATE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Podophyllotoxin Thioguanine. J Clin Pathol 1984;37(11):1259
TAPA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Prednisone Thioguanine. Gac Med Mex 1984;120(4):145
TRAMPCOL protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Methotrexate Prednisolone Thioguanine Vincristine. Med Clin North Am 1984;68(3):713
ACT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Thioguanine. J Clin Oncol 1984;2(4):253
BACT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Cytarabine Thioguanine. Eur J Cancer Clin Oncol 1983;19(10):1371
TRAMPCO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Daunorubicin Methotrexate Prednisolone Thioguanine Vincristine. Scand J Haematol 1983;31(5):403
DAT protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Thioguanine. Onkologie 1983;6(4):179
TACC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Lomustine Thioguanine. Presse Med 1983;12(31):1917
COATA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Thioguanine Vincristine. Tumori 1983;69(3):239
TOAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Prednisolone Thioguanine Vincristine. Tumori 1983;69(3):239
DCTP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Prednisolone Thioguanine. Rinsho Ketsueki 1982;23(11):1681
L-6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Cytarabine Daunorubicin Hydroxyurea Methotrexate Thioguanine Vincristine. Cancer 1982;50(8):1462
CT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Thioguanine. Aust NZ J Med 1982;12(3):238
6-methylthioguanine  1198-47-6   Thioguanine/*analogs & derivatives. Eur J Pharmacol 1982;81(3):505
palladium thioguanine  0   *Organometallic Compounds Thioguanine/*analogs & derivatives Palladium. Br J Cancer 38(2):325;1978
1-deaza-6-thioguanine  60282-76-0   Thioguanine/*analogs & derivatives. J Org Chem 41(24):3784;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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