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Thiophenes

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Definition:      
Examples Carticaine; Ketotifen; Morantel; Pizotyline; Pyrantel; Thenoyltrifluoroacetone; Thienopyridines; Thioctic Acid; Ticrynafen; Tiletamine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-((2-methylbenzofuran-3-yl)methyl)-3-(thiophen-2-ylmethyl)urea  0   *Methylurea Compounds *Thiophenes. Mol Pharm. 2011 Dec 5;8(6):2424-33.
4,11-bis((2-((acetimido)amino)ethyl)amino)anthra(2,3-b)thiophene-5,10-dione  0   *Anthraquinones *Thiophenes. PLoS One. 2011;6(11):e27151.
4-(3-ethylthiophenyl)-2-(3-thienyl)-1H-imidazole  0   *Imidazoles *Thiophenes Cholinesterase Inhibitors. Eur J Pharm Sci. 2012 Jan 23;45(1-2):169-83
3-bromo-N-(4-fluorobenzyl)-benzo(b)thiophene-2-carboxamide  0   *Thiophenes Antimalarials. IUBMB Life. 2011 Dec;63(12):1111-5
methyl 2-(cyclohexanecarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate  0   *Thiophenes Adamantane/*analogs & derivatives GABA-B Receptor Agonists. J Pharmacol Exp Ther. 2012 Mar;340(3):529-38.
methyl 2-(1-adamantanecarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate  0   *Thiophenes Adamantane/*analogs & derivatives GABA-B Receptor Agonists. J Pharmacol Exp Ther. 2012 Mar;340(3):529-38.
3-(2-(3-(morpholinomethyl)phenyl)thieno(3,2-b)pyridin-7-ylamino)phenol  0   *Aminopyridines *Thiophenes. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9.
N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide  0   *Indoles *Thiophenes Nitric Oxide Synthase Type I/antagonists & inhibitors. J Med Chem. 2012 Jan 26;55(2):943-55.
desmethylarzoxifene  0   *Piperidines *Thiophenes. Mol Cell Endocrinol. 2004 May 31;220(1-2):97-107.
2-(6-amino-2-(hex-1-enyl)-9H-purine-9-yl)tetrahydrothiophene-3,4-diol  0   *Thiophenes Adenosine/*analogs & derivatives Adenosine A2 Receptor Agonists Adenosine A3 Receptor Antagonists. J Med Chem. 2012 Jan 12;55(1):342-56
2-(6-amino-2-(hex-1-ynyl)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol  0   *Thiophenes Adenosine/*analogs & derivatives Adenosine A2 Receptor Agonists Adenosine A3 Receptor Antagonists. J Med Chem. 2012 Jan 12;55(1):342-56
1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone  0   *Thiophenes. Chem Biol. 2011 Nov 23;18(11):1401-12.
9-methyl-4-phenyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine  0   *Azepines *Thiophenes. Br J Pharmacol. 2011 Nov;164(6):1642-51.
DB1127  0   *Guanidines *Thiophenes. Antimicrob Agents Chemother. 2011 Oct;55(10):4866-72.
garlicnin A  0   *Thiophenes. Chem Pharm Bull (Tokyo). 2011;59(11):1340-3
poly(2,7-(9,9-bis(2'-ethylhexyl)fluorene)-alt-2,5-terthiophene)  0   *Fluorenes *Thiophenes. J Phys Chem B. 2011 Oct 27;115(42):12028-35
echinopsacetylene B  0   *Thiophenes *Polyacetylenes. Org Lett. 2011 Dec 2;13(23):6228-31
echinopsacetylene A  0   *Thiophenes *Polyacetylenes Isoptera/drug effects. Org Lett. 2011 Dec 2;13(23):6228-31
1-benzothiophen-2-yl-(4-dimethylaminophenyl)methanol  0   *Thiophenes. Exp Hematol. 2012 Jan;40(1):22-34
3'-O-methylponkoranol  0   *Thiophenes. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6491-4
3,4-dimethylthieno(2,3-b)thiophene  0   *Thiophenes. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Nov;82(1):340-4
poly(3,4-ethyleneoxythiathiophene)  0   *Thiophenes. J Am Chem Soc. 2011 Oct 5;133(39):15627-34
4-(benzo(b)thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one  0   *Thiophenes 4-Butyrolactone/*analogs & derivatives. J Pharmacol Exp Ther. 2011 Nov;339(2):716-25.
1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one  0   *Piperazines *Thiophenes Thioctic Acid/*analogs & derivatives Cholinesterase Inhibitors. Neurochem Int. 2011 Oct;59(5):722-8
3-amino-N-(4-chlorobenzyl)-6-(3-methoxyphenyl)thieno(2,3-b)pyridine-2-carboxamide  0   *Pyridines *Thiophenes. Cancer Lett. 2011 Dec 26;313(1):44-53.
4-thiophenyl-N-(N',N'-dimethylaminoethyl)-1,8-naphthalimide  0   *Thiophenes *Naphthalimides. J Photochem Photobiol B. 2011 Oct 5;105(1):75-80
(2R,3R,4S,5S,6R)-2-(5-chloro-4-(4-ethylbenzyl)thiophen-2-yl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol  0   *Thiophenes Hypoglycemic Agents. Bioorg Med Chem. 2011 Oct 1;19(19):5813-32
6-bromo-3-methylthieno(3,2-b)thiophene-2-carboxylic acid  0   *Thiophenes. J Med Chem. 2011 Oct 27;54(20):7385-96.
4-benzyloxyphenyl-(2-thienyl)iodonium bromide  0   *Onium Compounds *Thiophenes. Molecules. 2011;16(9) (dup#20):7621-6
tris(4-(thien-2-yl)phenyl)amine  0   *Aniline Compounds *Thiophenes. Chemphyschem. 2011 Apr 18;12(6):1155-64
3,6-dithiophen-2-yl-9H-carbazole  0   *Carbazoles *Thiophenes. J Org Chem. 2011 Jul 15;76(14):5685-95
2,7,12-tri(2-thiophenevinyl)-5,5',10,10',15,15'-hexaethyltruxene  0   *Thiophenes *Vinyl Compounds. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1112-5
2,7-di(2-thiophenevinyl)-5,5',10,10',15,15'-hexaethyltruxene  0   *Thiophenes *Vinyl Compounds. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1112-5
2-phenylacetylthiophene  0   *Thiophenes. J Phys Chem B. 2011 Jun 30;115(25):8102-11
1,2-bis(2-methyl-6-nitro-1-benzothiophen-3-yl)perfluorocyclopentene  0   *Cyclopentanes *Fluorocarbons *Thiophenes. Chemistry. 2011 Aug 22;17(35):9825-31
3-chloro-N-((1-methylpiperidin-2-yl)(thiophen-3-yl)methyl)-4-(trifluoromethyl)picolinamide  0   *Thiophenes Niacinamide/*analogs & derivatives Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors. PLoS One 2011;6(6):e21322
2-acetyl-3-hydroxy-5-(prop-1-ynyl)thiophen 3-O-beta-D-glucopyranoside  0   *Glucosides *Thiophenes. J Asian Nat Prod Res. 2011 Sep;13(9):845-50
SR 3335  0   *Sulfonamides *Thiophenes. ACS Chem Biol 2011 Mar 18;6(3):218-22
N-(3-fluoro-4-(5-phenylthieno(2,3-d)pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide  0   *Pyrimidines *Thiophenes. Bioorg Med Chem 2011 Jul 1;19(13):3906-18
3-(4,8,12,16-tetramethyl-heptadeca-3,7,11,15-tetraenyl)thiophene-1-oxide  0   *Thiophenes *Sesterterpenes. J Asian Nat Prod Res. 2011 Sep;13(9):879-83
GSK 461364  0   *Benzimidazoles *Thiophenes. Clin Cancer Res 2011 May 15;17(10):3420-30
ethyl 2-methylthiophene-3-carboxylate  0   *Thiophenes. Chem Pharm Bull (Tokyo). 2011;59(6):797-8
3-(2-(dimethylamino)ethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):
3-(diethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):4077-91
N-hydroxy-4-(3-(3-methoxy-4-(thiophen-2-ylmethyl)phenyl)propanamido)benzamide  0   *Benzamides *Thiophenes Breast Neoplasms/drug therapy. Cancer Biol Ther. 2011 Mar 1;11(5):477-89
2,6-dibromo-dithienothiophene  0   *Thiophenes. J Org Chem. 2011 May 20;76(10):4088-93
2,4,6-tris(thiophen-2-yl)-1,3,5-triazine  0   *Thiophenes *Triazines. Phys Chem Chem Phys. 2011 May 21;13(19):8838-46
2,7-dioctyl(1)benzothieno(3,2-b)(1)benzothiophene  0   *Thiophenes. Nature. 2011 Jul 21;475(7356):364-7
N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-2-carboxamide  0   *Pyrimidinones *Thiophenes. J Pharmacol Exp Ther 2011 Jul;338(1):154-63
BDM 31343  0   *Oxadiazoles *Thiophenes. Nat Med 2009 May;15(5):537-44
1-(thiophen-3-yl)ethanone  0   *Thiophenes. Acta Crystallogr C. 2011 Jun;67(Pt 6):o209-11
N-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide  0   *Isoxazoles *Thiophenes. Differentiation 2011 Apr;81(4):233-42
1,4-dideoxy-1,4-((2,3-dihydroxypropyl)episulfoniumylidene)arabinitol  0   *Sugar Alcohols *Thiophenes alpha-Glucosidases. Bioorg Med Chem 2011 Mar 15;19(6):2015-22
1,4-dideoxy-1,4-((2,3,4,5,6-pentahydroxyhexyl)episulfoniumylidene)arabinitol  0   *Sugar Alcohols *Thiophenes alpha-Glucosidases/antagonists & inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):2015-22
2,5-bis(amidinophenyl)-3,4-ethylenedioxythiophene  0   *Thiophenes. Eur J Med Chem. 2011 Feb;46(2):743-55
2-(benzo(b)thiophen-3'-yl)-6,8,8-triethyldesmosdumotin B  0   *Chromones *Thiophenes. J Med Chem 2011 Mar 10;54(5):1244-55
SR 8278  0   *Isoquinolines *Thiophenes Nuclear Receptor Subfamily 1, Group D, Member 1/antagonists & inhibitors. ACS Chem Biol 2011 Feb 18;6(2):131-4
ELR 510444  0   *Sulfonamides *Thiophenes Tubulin Modulators. J Pharmacol Exp Ther 2011 Mar;336(3):652-60
ibodutant  0   *Dipeptides *Thiophenes Receptors, Neurokinin-2/antagonists & inhibitors. Neurogastroenterol Motil 2011 Jan;23(1):96-102,e10
STF 083010  0   *Sulfonamides *Thiophenes. Blood 2011 Jan 27;117(4):1311-4
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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