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Thromboplastin

More information in Books or onNLM PubMed
Definition: Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.     
Pharmacological Action Hemostatics
See Also Coagulants 		Other names Tissue Thromboplastin; Tissue Factor; Factor III; Coagulation Factor III; CD142 Antigens; Antigens, CD142; Thromboplastin, Tissue; Procoagulant, Tissue Factor; Procoagulant Activity, Glomerular; Factor III, Coagulation; Activity, Glomerular Procoagulant; Urothromboplastin; Tissue Factor Procoagulant; Prothrombinase; Glomerular Procoagulant Activity; Blood Coagulation Factor III; Coagulin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-amino-5-(1-(2-((4-(amino(imino)methyl)benzyl)amino)-2-oxoethyl)-3-chloro-5-(isopropylamino)-6-oxo-1,6-dihydropyrazin-2-yl)benzoic acid  0   *Aminobenzoic Acids *Pyrazines Thromboplastin/antagonists & inhibitors Factor VIIa/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Sep;306(3):1115-21
5-(5-amidinoindol-2-yl)-6-hydroxy-3-((3-nitrophenyl)phenyl)acetic acid  0   *Amidines *Phenylacetates Thromboplastin/antagonists & inhibitors Factor VIIa/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2253-6
Innovin  0   *Thromboplastin Recombinant Proteins. Blood Coagul Fibrinolysis 1993 Jun;4(3):497-8
endothelial cell procoagulant activity  0   *Thromboplastin. Thromb Res 1987;47(1):69
thromboplastin apoprotein, human  0   *Apoenzymes *Thromboplastin. Thromb Res 1987;45(5):609
prothrombinase complex  0   *Factor V *Factor Xa Thromboplastin. Chem Biol Thrombin WH 310 C748c; p.291;1977; J Biol Chem 255(1):274;1980
Thrombofax  39355-51-6   *Thromboplastin. Acta Haematol (Basel) 56:307;1976; Experientia 28(9):1127;1973; Experientia 34(5):661;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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