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Thrombopoietin

More information in Books or onNLM PubMed
Definition: A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.      Other names c-mpl Ligand; Megakaryocyte Growth and Development Factor; Thrombocytopoiesis Stimulating Factor; Ligand, mpl; Ligand, c-mpl; mpl Ligand; Thrombocytopoietin; Thrombocytopoiesis-Stimulating Factor; Myeloproliferative Leukemia Virus Oncogene Ligand; Megakaryocyte Colony Stimulating Factor; MGDF Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ALXN4100TPO  0   *Antibodies, Monoclonal *Thrombopoietin Receptors, Thrombopoietin/agonists. Radiat Res. 2011 Jun;175(6):746-58
RWJ 800088  0   *Peptides Thrombopoietin/antagonists & inhibitors. Clin Pharmacol Ther 2008 Oct;84(4):481-7
romiplostim  0   *Receptors, Fc *Recombinant Fusion Proteins *Thrombopoietin Receptors, Thrombopoietin/agonists. Cytokine 2004 Jan 21;25(2):52-60NPLATE
promegapoietin-1a  0   *Interleukin-3 *Recombinant Fusion Proteins *Thrombopoietin. Stem Cells 2001;19(4):329-38
GW395058  0   *Peptides Thrombopoietin Molecular Mimicry. Stem Cells 1999 ;17(4):203-9
polyethylene glycol-recombinant human megakaryocyte growth and development factor  0   *Polyethylene Glycols *Thrombopoietin Recombinant Proteins. Blood 1997 Jan 1;89(1):155-65
megapoietin protein, Ovis aries  158254-29-6 Megapoietin  *Thrombopoietin. Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11104-8
MPL protein, human  143641-95-6   *Receptors, Thrombopoietin Thrombopoietin. Embo J 1993 Jul;12(7):2645-53; Proc Natl Acad Sci USA 1992 Jun 15;89(12):5640-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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