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Thymidine Phosphorylase

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Definition: An enzyme that catalyzes the transfer of 2-deoxy-D-ribose from THYMIDINE to orthophosphate, thereby liberating thymidine.      Other names Platelet Derived Endothelial Cell Growth Factor; Gliostatin; Platelet-Derived Endothelial Cell Growth Factor; PD-ECGF
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-fluoro-6-((2-iminopyrrolidin-1-yl)methyl)uracil  0   *Pyrrolidines Uracil/*analogs & derivatives Fluorine Radioisotopes Thymidine Phosphorylase/antagonists & inhibitors. Nucleosides Nucleotides Nucleic Acids 2010 Jan;29(1):49-54
Tymp protein, mouse  EC 2.4.2.4   *Thymidine Phosphorylase.
TYMP protein, human  EC 2.4.2.4   *Thymidine Phosphorylase.
1-(3-fluoro-2-(phosphonomethoxy)propyl)thymine  0   *Phosphonic Acids Thymine/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 2005 May 15;69(10):1517-21
6-chloro-5-cyclopent-1-en-1-yluracil  0   Uracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. J Med Chem 2007 Nov 29;50(24):6016-23
5'-O-tritylinosine  0   *Trityl Compounds Inosine/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. J Med Chem 2006 Sep 7;49(18):5562-70
6-imidazolylmethyl-5-fluorouracil  0   *Imidazoles Fluorouracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Nucleosides Nucleotides Nucleic Acids 2005;24(5-7):367-73
1-(8-phosphonooctyl)-7-deazaxanthine  0   *Xanthines Thymidine Phosphorylase/antagonists & inhibitors. FEBS Lett 2002 Jan 2;510(1-2):83-8
1-(8-phosphonooctyl)-2,4-dioxopyrrolo(2,3-d)pyrimidine  0   *Phosphonic Acids *Pyrimidinones Thymidine Phosphorylase/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):971-83
6-amino-5-bromo-1-(8-phosphonooctyl)uracil  0   *Phosphonic Acids Uracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):971-83
5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride  0   *Pyrrolidines Uracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Cancer Res 1999 Apr 15;59(8):1911-6
CA 423  0   *Organophosphorus Compounds *Propionic Acids Thymidine Phosphorylase. Bioorg Khim 1998 Dec;24(12):920-5
7-deazaxanthine  0   *Xanthines Thymidine Phosphorylase/antagonists & inhibitors. FEBS Lett 1998 Oct 30;438(1-2):91-5
N-(2-(hydroxyethoxy)methyl)-5-methyluracil  68724-11-8   Uracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Int J Appl Radiat Isot 1985;36(5):395
5-fluoro-(2',3')-dideoxy-3'-fluorouridine 5'-phosphate  87395-48-0   *Deoxyuracil Nucleotides *Dideoxynucleotides Thymidylate Synthase/antagonists & inhibitors Thymidine Phosphorylase/antagonists & inhibitors. J Med Chem 1984;27(1):11
5-fluoro-2',3'-dideoxy-3'-fluorouridine  41107-55-5   *Dideoxynucleosides Thymidine Phosphorylase/antagonists & inhibitors. J Med Chem 1984;27(1):11
6-amino-5-bromouracil  6312-73-8   Bromouracil/*analogs & derivatives Thymidine Phosphorylase/antagonists & inhibitors. Biochem Pharmacol 1983;32(23):3583

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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