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Tobramycin

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Definition: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.     
Pharmacological Action Anti-Bacterial Agents 		Other names Sulfate, Tobramycin; Tobramycin Sulfate; Tobracin; Obracin; Nebicin; Nebcin; Brulamycin; Nebramycin Factor 6Drugs* : TOBRAMYCIN SULFATE; TOBREX; AKTOB; TOBRAMYCIN; TOBRAMYCIN SULFATE IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER; TOBRAMYCIN SULFATE (PHARMACY BULK); NEBCIN; TOBI
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2''-(adenosine-5'-phosphoryl)tobramycin  114550-26-4   Adenosine Monophosphate/*analogs & derivatives Tobramycin/*analogs & derivatives. Arch Biochem Biophys 1990;280(2):284
2''-(adenosine-5'-thiophosphoryl)tobramycin  129545-98-8   Adenosine Monophosphate/*analogs & derivatives Tobramycin/*analogs & derivatives. Arch Biochem Biophys 1990;280(2):284
6''-O-carbamoyltobramycin  51736-77-7   Tobramycin/*analogs & derivatives. Acta Microbiol Hung 1988;35(2):89
6'-N-4-azidobenzyltobramycin  85733-85-3 D-Streptamine, O-2-amino-6-(((4-azidophenyl)methyl)amino)-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4)-O-(3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6))-2-deoxy  *Azides Tobramycin/*analogs & derivatives. Eur J Biochem 1983;131(3):581
6'-N-acetyltobramycin  61083-42-9 O-6-(acetylamino)-2-amino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4)-O-(3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6))-2-deoxy-D-strept amine  Tobramycin/*analogs & derivatives. Eur J Biochem 102(1):73;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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