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Trimethoprim

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Definition: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.  consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria   
Pharmacological Action Antimalarials; Anti-Infective Agents, Urinary; Folic Acid Antagonists
See Also Trimethoprim Resistance
Examples Trimethoprim-Sulfamethoxazole Combination 		Other names Trimpex; ProloprimDrugs* : TRIMPEX; TRIMETHOPRIM; PROLOPRIM; TRIMPEX 200; PRIMSOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,4-diamino-5-(2-methoxy-5-(4-carboxybutyloxy)benzyl)pyrimidine  0   Trimethoprim/*analogs & derivatives. Proteins 2006 Dec 1;65(4):959-69
2,4-diamino-5-(3,4-dimethoxy-5-(5-carboxy-1-pentynyl))benzylpyrimidine  0   Trimethoprim/*analogs & derivatives. Proteins 2006 Dec 1;65(4):959-69
trimethoprim picolinate  0   *Picolinic Acids Trimethoprim/*analogs & derivatives. Acta Crystallogr C. 2006 Feb;62(Pt 2):o107-10
cotrifazid  0   *Isoniazid *Rifampin *Sulfamethoxazole *Trimethoprim Drug Combinations. Chemotherapy 1996 Nov-Dec;42(6):391-401
epiroprim  73090-70-7   Trimethoprim/*analogs & derivatives. Antimicrob Agents Chemother 1993 Jul;37(7):1436-43
potrox  51404-58-1   *Trimethoprim Drug Combinations Sulfamethoxazole/*analogs & derivatives. Acta Vet Scand Suppl 1991;87:359-62
sulfaton  39469-68-6   *Sulfamonomethoxine *Trimethoprim Drug Combinations. Antibiotic Khimoter 1989;34(9):657
Polytrim eyedrops  53320-96-0   *Polymyxin B *Trimethoprim Drug Combinations. Drug Ther Bull 1988;26(11):43TRIMETHOPRIM SULFATE AND POLYMYXIN B SULFATE; POLYTRIM
aditoprim  56066-63-8   Trimethoprim/*analogs & derivatives Tetrahydrofolate Dehydrogenase/antagonists & inhibitors. J Chromatogr 1986;383(1):111
2,4-diamino-5-((3,5-dimethoxy-4-(4-bromoacetamidophenoxy)benzyl)pyrimidine)  78025-83-9   Trimethoprim/*analogs & derivatives. J Biol Chem 1984;259(19):12299
brodimoprim  56518-41-3   Trimethoprim/*analogs & derivatives.
Pharma Action Anti-Infective Agents ; Enzyme Inhibitors ; Folic Acid Antagonists 		Acta Pharmacol Toxicol 1982;51(5):446
metioprim  68902-57-8   Trimethoprim/*analogs & derivatives. Arzneimittelforsch 1982;32(10):1302
trimethoprim sulfamethizole  79735-35-6 Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine  *Sulfamethizole *Trimethoprim Drug Combinations. J Chir (Paris) 1981;116(11):637
kelfiprim  50933-06-7   *Sulfalene *Trimethoprim Drug Combinations. J Antimicrob Chemother 1980;6(5):647
sulfadiazine, trimethoprim drug combination  39474-58-3 benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine  *Sulfadiazine *Trimethoprim Drug Combinations.
Pharma Action Anti-Infective Agents, Urinary 		NZ Med J 1980;91(652):43
Rifaprim  61498-94-0 3-(((4-methyl-1-piperazinyl)imino)methyl)rifamycin, mixt. with 5-((3,4,5-trimethoxyphenyl) methyl)-2,4-pyrimidinediamine  *Rifampin *Trimethoprim Drug Combinations. J Int Med Res 7(2):132;1979
trimerazine  54242-77-2 4-amino-N-(4-methyl-2-pyrimidinyl)benzenesulfonamide, mixt. with 5-((3,4,5-trimethoxyphenyl)meth yl)-2,4-pyrimidinediamine  *Sulfamerazine *Trimethoprim Drug Combinations. Med Weteryn 32(11):684-92;1976
sulfamoxole, trimethoprim drug combination  57197-43-0   *Sulfamoxole *Trimethoprim Drug Combinations. Ther Gaw 115(3):896;1976
lidaprim  63749-94-0   *Sulfanilamides *Trimethoprim Drug Combinations. Int J Clin Pharmacol Biopharm 15(7):310;1977; Wien Klin Wochenschr 87(18):611;1975; Wien Med Wochenschr 129(3):81;1979; Wien Med Wochenschr 1979;129(suppl 59):3
Poteseptyl  54242-79-4   *Sulfamethazine *Trimethoprim Drug Combinations. Chemotherapy 20(2):113;1974; Ther Hung 25(2):79;1977
trimethoprim, sulfadoxine drug combination  39295-60-8   *Sulfadoxine *Trimethoprim Drug Combinations. Schweiz Arch Tierheilk 387;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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