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Tryptophan Hydroxylase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.     
See Also Tryptophan Oxygenase 		Other names Tryptophan Monooxygenase; Monooxygenase, Tryptophan; Hydroxylase, Tryptophan
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-3-(4-(2-amino-6-(2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)-pyrimidin-4-yl)phenyl)propionic acid  0   *Biphenyl Compounds Phenylalanine/*analogs & derivatives Tryptophan Hydroxylase/antagonists & inhibitors. IDrugs 2010 Dec;13(12):921-8
tph1 protein, rat  EC 1.14.16.4   *Tryptophan Hydroxylase. Eur J Neurosci. 2005 Aug;22(4):895-901
tph2 protein, rat  EC 1.14.16.4   *Tryptophan Hydroxylase. Eur J Neurosci. 2005 Aug;22(4):895-901
TPH1 protein, human  EC 1.14.16.4   *Tryptophan Hydroxylase Biological Markers. Genes Brain Behav. 2004 Dec;3(6):328-36
TPH2 protein, human  EC 1.14.16.4   *Tryptophan Hydroxylase. Science 2003 Jan 3;299(5603):76
Tph2 protein, mouse  EC 1.14.16.4   *Tryptophan Hydroxylase. Science 2003 Jan 3;299(5603):76
Tph1 protein, mouse  EC 1.14.16.4   *Tryptophan Hydroxylase. J Soc Biol 2004;198(1):7-17
p-ethynylphenylalanine  0   Alanine/*analogs & derivatives Tryptophan Hydroxylase/antagonists & inhibitors. J Neurochem 2000 May;74(5):2067-73
AGN 2979  53873-21-5   *Piperidones Tryptophan Hydroxylase/antagonists & inhibitors. Biochem Pharmacol 1986;35(9):1521
3,4-dihydroxystyrene  6053-02-7   *Styrenes Phenylalanine Hydroxylase/antagonists & inhibitors Tryptophan Hydroxylase/antagonists & inhibitors Tyrosine 3-Monooxygenase/antagonists & inhibitors. Biochim Biophys Acta 1984;789(2):111

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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