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Tumor Markers, Biological

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Definition: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.  IM; coord with specific substance (IM) if pertinent; DF: TUMOR MARKERS; Manual 24.4.4.5   
Examples alpha-Fetoproteins; Antigens, CD30; Antigens, Tumor-Associated, Carbohydrate; Carcinoembryonic Antigen; Chorionic Gonadotropin, beta Subunit, Human; Hormones, Ectopic; Ki-67 Antigen; Mammaglobin A; Nephroblastoma Overexpressed Protein; Neprilysin; Normetanephrine; Proliferating Cell Nuclear Antigen; Prostate-Specific Antigen; Receptor, erbB-2; Receptor, erbB-3; Synaptophysin; Tissue Kallikreins; Tissue Polypeptide Antigen 		Other names Tumor Metabolite Markers; Tumor Markers; Tumor Marker, Biological; Tumor Marker, Biologic; Tumor Marker, Biochemical; Neoplasm Metabolite Marker; Metabolite Marker, Tumor; Metabolite Marker, Neoplasm; Markers, Carcinogen; Markers, Biologic Tumor; Biologic Tumor Markers; Tumor Markers, Biochemical; Metabolite Markers, Neoplasm; Markers, Tumor; Carcinogen Markers; Biologic Tumor Marker; Biochemical Tumor Marker; Tumor Metabolite Marker; Tumor Markers, Biologic; Neoplasm Metabolite Markers
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
exposed proliferation antigen 210  0   *Peptide Fragments *Thymidine Kinase Tumor Markers, Biological. BJU Int. 2012 Feb;109(4):634-8.
FSTL5 protein, human  0   *Follistatin-Related Proteins Tumor Markers, Biological. J Clin Oncol. 2011 Oct 10;29(29):3852-61
PLXDC2 protein, human  0   *Receptors, Cell Surface Neoplasm Proteins Tumor Markers, Biological. Ophthalmology. 2011 Apr;118(4):642-8
melanoma-derived CT16 cancer testis antigen, human  0   *Melanoma-Specific Antigens Tumor Markers, Biological. Int J Cancer. 2011 May 15;128(10):2382-92
Nope protein, human  0   *Immunoglobulins *Nerve Tissue Proteins Carcinoma, Hepatocellular Tumor Markers, Biological. Int J Cancer. 2011 May 15;128(10):2353-63
EM66 peptide  0   *Peptide Fragments *Secretogranin II Tumor Markers, Biological. Neurosci Lett. 2007 Mar 13;414(3):268-72
Biot2 protein, human  0   *Neoplasm Proteins Tumor Markers, Biological. Oncol Rep 2011 Jan;25(1):75-80
MALAT1 long non-coding RNA, human  0   *RNA, Untranslated Tumor Markers, Biological. Oncogene. 2007 Feb 8;26(6):851-8
Malat1 long non-coding RNA, mouse  0   *RNA, Untranslated Tumor Markers, Biological. Oncogene. 2007 Feb 8;26(6):851-8
MUC12 protein, human  0   *Mucins Tumor Markers, Biological. Int J Cancer. 2010 Nov 15;127(10):2292-9
PAM4 protein, human  0   *Antigens, Neoplasm Pancreatic Neoplasms Tumor Markers, Biological. Cancer. 2010 Jun 1;116(11):2505-6
CHDL1 protein, mouse  EC 3.6.1.-   *DNA Helicases *DNA-Binding Proteins Tumor Markers, Biological. PLoS One. 2009;4(8) (dup#10):e6727
CHD1L protein, human  EC 3.6.1.-   *DNA Helicases *DNA-Binding Proteins Tumor Markers, Biological. Science. 2009 Sep 4;325(5945):1240-3
claudin-5 protein, dog  0   *Claudins Tumor Markers, Biological. Histol Histopathol. 2009 Jul;24(7):801-13
GBP2 protein, human  EC 3.6.1.-   *GTP-Binding Proteins Tumor Markers, Biological. Int J Cancer 2009 Jan 15;124(2):272-9
FBXL17 protein, human  0   *F-Box Proteins Tumor Markers, Biological. Cancer Genomics Proteomics. 2008 May-Aug;5(3-4):151-60
MIRN125 microRNA, human  0   *MicroRNAs Tumor Markers, Biological. Am J Hum Genet 2008 Aug;83(2):243-53
integrin alphaupsilonbeta6  0   *Integrins Colonic Neoplasms Tumor Markers, Biological. Int J Cancer 2008 Sep 15;123(6):1311-7
BJ-TSA-9 protein, human  0   *Neoplasm Proteins Tumor Markers, Biological. Biochem Biophys Res Commun 2008 Aug 8;372(4):756-60
CRALBPL protein, human  0   *Carrier Proteins Tumor Markers, Biological. DNA Cell Biol 2008 Mar;27(3):159-63
colon cancer-specific antigen 2, human  0   *Antigens, Neoplasm *Nuclear Proteins Colorectal Neoplasms Tumor Markers, Biological. Clin Cancer Res 2008 Mar 1;14(5):1349-54
Antxr1 protein, mouse  0   *Tumor Markers, Biological *Receptors, Peptide. Microb Pathog 2007 Jul;43(1):37-45
4C5 monoclonal antibody  0   *Antibodies, Monoclonal Tumor Markers, Biological. Clin Cancer Res 2007 Mar 15;13(6):1831-8
TRA-1-81 antigen, human  0   *Antigens, Surface Tumor Markers, Biological. Stem Cells 2007 Mar;25(3):723-30
TCTP protein, Drosophila  0   *Tumor Markers, Biological *Drosophila Proteins. Nature. 2007 Feb 15;445(7129):785-8
MIEN1 protein, human  0   *Neoplasm Proteins *Intracellular Signaling Peptides and Proteins Tumor Markers, Biological. Mol Cancer Ther 2006 Nov;5(11):2919-30
BAT26 microsatellite DNA  0   *Genetic Markers *Tumor Markers, Biological *Microsatellite Repeats. World J Gastroenterol. 2006 Aug 28;12(32):5148-52
Adnab-9  0   *Tumor Markers, Biological. Dig Dis Sci. 2006 Dec;51(12):2213-9
FAM163A protein, human  0   *Membrane Proteins *Neoplasm Proteins Tumor Markers, Biological. J Pediatr Surg 2007 Jan;42(1):148-52
FAM129A protein, human  0   *Neoplasm Proteins *Tumor Markers, Biological. Hum Pathol 2006 Dec;37(12):1592-600
UCA1 RNA, human  0   *RNA, Untranslated Tumor Markers, Biological. Clin Cancer Res 2006 Aug 15;12(16):4851-8
Car8 protein, mouse  0   *Nerve Tissue Proteins *Tumor Markers, Biological.
CA8 protein, human  0   *Tumor Markers, Biological.
OR51E1 protein, human  0   *Neoplasm Proteins *Receptors, G-Protein-Coupled Tumor Markers, Biological. Prostate 2006 Jun 1;66(8):847-57
PLXDC1 protein, human  0   *Neoplasm Proteins *Receptors, Cell Surface Tumor Markers, Biological. Cancer Res 2001 Sep 15;61(18):6649-55
CHMP2A protein, human  0   *Endosomal Sorting Complexes Required for Transport Tumor Markers, Biological. Nucleic Acids Res. 2006;34(2) (dup#5):e13; Trends Biochem Sci. 2007 Dec;32(12):561-73
S100A7 protein, mouse  0   *S100 Proteins Tumor Markers, Biological. BMC Cancer 2005 Feb 17;5(1):17
PCA-1 antigen, human  0   *Antigens, Neoplasm Prostatic Neoplasms Tumor Markers, Biological. Clin Cancer Res 2005 Jul 15;11(14):5090-7
PPP2R5C protein, human  EC 3.1.3.16   *Protein Phosphatase 2 Tumor Markers, Biological. Exp Hematol 2005 Aug;33(8):883-93
B305D-C protein, human  0   *Neoplasm Proteins Tumor Markers, Biological. Clin Cancer Res 2005 May 15;11(10):3722-32
TEM7 protein, rat  0   *Membrane Proteins *Nerve Tissue Proteins Tumor Markers, Biological. Brain Res Mol Brain Res. 2005 May 20;136(1-2):189-98
monoclonal antibody D2-40  0   *Antibodies, Monoclonal, Murine-Derived Tumor Markers, Biological. Hum Pathol 2005 Apr;36(4):372-80
RM2 antigen, human  0   *Antigens, Tumor-Associated, Carbohydrate Tumor Markers, Biological. Int J Cancer 2005 May 20;115(1):105-13
KIAA1524 protein, human  0   *Autoantigens *Membrane Proteins Tumor Markers, Biological. Prostate 2005 May 15;63(3):252-8
VWA2 protein, human  0   *Tumor Markers, Biological. Oncogene. 2005 Jan 20;24(4):724-31
MECT1-MAML2 fusion protein, human  0   *Oncogene Proteins, Fusion Tumor Markers, Biological. J Mol Diagn. 2004 Aug;6(3):205-10
CRxA-01 antibody, human  0   *Antibodies, Neoplasm Tumor Markers, Biological. Cancer 2004 Dec 25;102(6):368-72
Cep290 protein, human  0   *Antigens, Neoplasm *Neoplasm Proteins Tumor Markers, Biological. Biochem Biophys Res Commun 2004 Nov 12;324(2):922-30
ARID4B protein, human  0   *Antigens, Neoplasm *Neoplasm Proteins DNA-Binding Proteins Tumor Markers, Biological. Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1136-45
Tdgf1 protein, mouse  0   *Epidermal Growth Factor *Membrane Glycoproteins *Neoplasm Proteins Growth Substances Tumor Markers, Biological.
PGP9.5 protein, rat  EC 3.1.2.-   *Ubiquitin Thiolesterase Tumor Markers, Biological. Nagoya J Med Sci 2004 May;67(1-2):25-34
PIP protein, human  0   *Carrier Proteins *Glycoproteins Tumor Markers, Biological.
AZGP1 protein, human  0   *Carrier Proteins *Glycoproteins Tumor Markers, Biological.
Hspb1 protein, rat  0   *HSP27 Heat-Shock Proteins Tumor Markers, Biological.
Hspb1 protein, mouse  0   *Heat-Shock Proteins *Neoplasm Proteins Tumor Markers, Biological.
BPIFA1 protein, human  0   *Glycoproteins *Phosphoproteins Tumor Markers, Biological Leucine Zippers.
PIK3CA protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases Tumor Markers, Biological. Science 2004 Apr 23;304(5670):554
HSAJ2425 protein, human  0   *Carrier Proteins *Neoplasm Proteins Tumor Markers, Biological.
Cdr1 protein, mouse  0   *Nerve Tissue Proteins Autoantigens Tumor Markers, Biological.
UCHL1 protein, human  EC 3.1.2.15   *Ubiquitin Thiolesterase Tumor Markers, Biological. Eur J Cancer. 2004 Mar;40(4); 614-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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