Tumor Necrosis Factor-alpha (definition)

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Tumor Necrosis Factor-alpha

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Definition: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Other names Tumor Necrosis Factor alpha; Cachectin Tumor Necrosis Factor; Tumor Necrosis Factor; TNFalpha; TNF Superfamily, Member 2; Cachectin-Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF-alpha; Cachectin

Substance	CAS Registry & name	Categories	Source	Drugs*
3,6'-dithiothalidomide	0	Thalidomide/*analogs & derivatives Tumor Necrosis Factor-alpha/antagonists & inhibitors.	J Neurochem 2011 Sep;118(6):1032-42
TIPE1 protein, human	0	*Intracellular Signaling Peptides and Proteins Tumor Necrosis Factor-alpha.	Mol Immunol. 2011 Jul;48(12-13):1548-55
TIPE1 protein, mouse	0	*Intracellular Signaling Peptides and Proteins Tumor Necrosis Factor-alpha.	Mol Immunol. 2011 Jul;48(12-13):1548-55
agallochaol Q	0	*Diterpenes Tumor Necrosis Factor-alpha/antagonists & inhibitors.	Phytochemistry. 2010 Dec;71(17-18):2124-31
XENP 1595	0	*Tumor Necrosis Factor-alpha.	J Infect Dis 2009 Apr 1;199(7):1053-63
mTNF-PADRE	0	*Tumor Necrosis Factor-alpha.	Cell Immunol 2007 Apr;246(2):55-64
5,N-dihydroxythalidomide	0	Thalidomide/*analogs & derivatives Tumor Necrosis Factor-alpha/antagonists & inhibitors.	Chem Pharm Bull (Tokyo) 2006 Dec;54(12):1709-14
2-amino-6-chloro-9-((5-dihydroxyboryl)pentyl)purine	0	Purines Boron Compounds Tumor Necrosis Factor-alpha/antagonists & inhibitors.	PLoS Med 2005 Sep;2(9):e245
Tipalpha protein, Helicobacter pylori	0	*Bacterial Proteins Tumor Necrosis Factor-alpha.	J Cancer Res Clin Oncol 2005 May;131(5):305-13
N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide	0	Benzamides Thiazoles Tumor Necrosis Factor-alpha/antagonists & inhibitors p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors.	Proc Natl Acad Sci U S A 2005 Sep 20;102(38):5966-79
3-chloro-4-dichloromethyl-5-dichloromethylene-2,4-dihydroxycyclopent-2-enone	0	*Cyclopentanes Tumor Necrosis Factor-alpha/antagonists & inhibitors.	Z Naturforsch (C) 2005 May-Jun;60(5-6):478-84
PEGylated tumor necrosis factor alpha receptor 1	0	Polyethylene Glycols Receptors, Tumor Necrosis Factor, Type I Tumor Necrosis Factor-alpha/antagonists & inhibitors.	Arthritis Rheum 2005 Jan;52(1):128-35
Tnfaip1 protein, mouse	0	*Proteins Tumor Necrosis Factor-alpha.
Tsg-5 protein, mouse	0	*DNA-Binding Proteins Tumor Necrosis Factor-alpha.	Genes Immun 2003 Jun;4(4);298-311
2,6-piperidinedithione	0	Piperidines Thiones Tumor Necrosis Factor-alpha/antagonists & inhibitors.	J Med Chem 2003 Nov 20;46(24):5222-9
LK-805	0	*Tumor Necrosis Factor-alpha.	Ann N Y Acad Sci 2002 Nov;973:194-206
abatacept	0	Immunoconjugates Arthritis, Rheumatoid Tumor Necrosis Factor-alpha. Pharma Action* Immunosuppressive Agents ; Antirheumatic Agents	Nat Immunol 2002 Nov;3(11):1056-7	ORENCIA; NULOJIX
tumor Necrosis Factor-alpha, CNGRC fusion protein, mouse	0	*Tumor Necrosis Factor-alpha.	J Clin Invest 2002 Aug;110(4):475-82
tumor necrosis factor-alpha, CNGRC fusion protein, human	0	Recombinant Fusion Proteins Tumor Necrosis Factor-alpha.	J Clin Invest 2002 Aug;110(4):475-82
TNF-selectokine	0	Tumor Necrosis Factor-alpha Single-Chain Antibodies.	Oncogene 2002 Jun 20;21(27):4257-65
adalimumab	0	Antibodies, Monoclonal, Humanized Arthritis, Rheumatoid Tumor Necrosis Factor-alpha. Pharma Action* Anti-Inflammatory Agents ; Antirheumatic Agents	Ann Rheum Dis 2002 Apr;61(4):311-8	HUMIRA
LZ-TRAIL protein, recombinant	0	Membrane Glycoproteins Recombinant Fusion Proteins *Tumor Necrosis Factor-alpha Apoptosis.	Leukemia 2002 Jan;16(1):67-73
His-TRAIL protein, recombinant	0	Membrane Glycoproteins Peptide Fragments Recombinant Fusion Proteins Tumor Necrosis Factor-alpha.	Leukemia 2002 Jan;16(1):67-73
3-(1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl)-1,6-dimethyl-2,4-(1H,3H)-quinazolinedione	0	Quinazolines Pyrimidinones Tumor Necrosis Factor-alpha/antagonists & inhibitors.	J Pharmacol Exp Ther 2002 Jan;300(1):200-5
TNF protein, human	0	*Tumor Necrosis Factor-alpha.	J Hepatol 2001 May;34(5):711-5
procurcumenol	21698-40-8	*Sesquiterpenes Stereoisomerism Tumor Necrosis Factor-alpha/antagonists & inhibitors.	Planta Med 2001 Aug;67(6):550-2
1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one	0	*Phenols Tumor Necrosis Factor-alpha/antagonists & inhibitors.	Planta Med 2001 Aug;67(6):550-2
1-(4-aminophenyl)methyl-3-(3-nitrophenyl)-1,3-dihydroimidazo(4,5-b)pyridine-2-one	0	*Pyridines Tumor Necrosis Factor-alpha/antagonists & inhibitors.	J Pharm Pharmacol 2000 May;52(5):531-8
tumor necrosis factor (41-62)	0	Peptide Fragments Tumor Necrosis Factor-alpha.	Thromb Haemost 2000 Apr;83(4):598-604
tumor necrosis factor (78-96)	0	Peptide Fragments Tumor Necrosis Factor-alpha.	Thromb Haemost 2000 Apr;83(4):598-604
TJU 103	0	*Organic Chemicals Interferon-gamma/antagonists & inhibitors Interleukin-1/antagonists & inhibitors Tumor Necrosis Factor-alpha/antagonists & inhibitors Interleukin-6/antagonists & inhibitors.	Antimicrob Agents Chemother 2000 Apr;44(4):1067-9
CDP 571	0	Antibodies, Monoclonal Tumor Necrosis Factor-alpha/antagonists & inhibitors. Pharma Action* Anti-Inflammatory Agents, Non-Steroidal ; Gastrointestinal Agents ; Antirheumatic Agents	Drugs R D 1999 Mar;1(3):253-5
RM4-TNF protein, recombinant	0	Immunoglobulin Fab Fragments Recombinant Fusion Proteins *Tumor Necrosis Factor-alpha.	Cancer Gene Ther 1998 Nov-Dec;5(6):371-9
TNFAIP1 protein, human	0	*Proteins Tumor Necrosis Factor-alpha.	Biochim Biophys Acta 1998 Nov 8;1442(2-3):394-8
tumor necrosis factor alpha (70-80)	0	Peptide Fragments Tumor Necrosis Factor-alpha.	Infect Immun 1998 Jun;66(6):2822-6
mutein TNF 471	0	*Tumor Necrosis Factor-alpha.	Cancer Res 1998 Apr 15;58(8):1677-83
mutein 5	0	*Tumor Necrosis Factor-alpha.	Leuk Res 1997 Sep;21(9):857-65
mutein 3	0	*Tumor Necrosis Factor-alpha.	Leuk Res 1997 Sep;21(9):857-65
tumor necrosis factor (1-12)	0	Peptide Fragments Tumor Necrosis Factor-alpha.	Eur J Immunol 1997 Oct;27(10):2588-92
TNF-SAM2	0	*Tumor Necrosis Factor-alpha.	Cytokines Mol Ther 1995 Sep;1(3):197-210
infliximab	0	Antibodies, Monoclonal Arthritis, Rheumatoid Crohn Disease Tumor Necrosis Factor-alpha. Pharma Action* Anti-Inflammatory Agents ; Dermatologic Agents ; Gastrointestinal Agents ; Antirheumatic Agents	N Engl J Med 1997 Oct 9;337(15):1029-35	REMICADE
RU 36156	0	*Hydroxamic Acids Metalloendopeptidases/antagonists & inhibitors Tumor Necrosis Factor-alpha.	Eur J Immunol 1997 May;27(5):1275-82
copper smelter dust	67711-90-4	*Copper Tumor Necrosis Factor-alpha.	J Toxicol Environ Health 1997 Jun 6;51(2):189-202
TNFR-Fc fusion protein	185243-69-0	Immunoglobulin G Receptors, Tumor Necrosis Factor Arthritis, Rheumatoid Recombinant Fusion Proteins Tumor Necrosis Factor-alpha. Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Gastrointestinal Agents ; Immunologic Factors ; Immunosuppressive Agents ; Antirheumatic Agents	J Immunol 1995 Nov 15;155(10):5038-45	ENBREL
mutein 6	0	*Tumor Necrosis Factor-alpha.	Int J Tissue React 1996;18(2-3):57-65
1-(3-(4-morpholinyl)propyl)-4-(4-fluorophenyl)-5-(4-pyridyl)imidazole	0	Imidazoles Morpholines Tumor Necrosis Factor-alpha/antagonists & inhibitors.	J Med Chem 1996 Sep 27;39(20):3929-37
tumor necrosis factor-alpha convertase	EC 3.4.24.-	*ADAM Proteins Tumor Necrosis Factor-alpha Amyloid Precursor Protein Secretases.	Biochem Biophys Res Commun 1996 Aug 14;225(2):400-5
tetrafluorothalidomide	0	Thalidomide/*analogs & derivatives Tumor Necrosis Factor-alpha/antagonists & inhibitors.	J Med Chem 1996 Aug 2;39(16):3044-5
Ro 45-2081	0	Immunoglobulin gamma-Chains Receptors, Tumor Necrosis Factor Recombinant Fusion Proteins Tumor Necrosis Factor-alpha/antagonists & inhibitors.	Am J Respir Cell Mol Biol 1996 May;14(5):454-60
trichodimerol	0	*Bridged Compounds Tumor Necrosis Factor-alpha/antagonists & inhibitors.	J Antibiot (Tokyo) 1996 Mar;49(3):234-40
F 4168	0	*Tumor Necrosis Factor-alpha.	J Interferon Cytokine Res 1995 Feb;15(2):161-9
F 4614	0	*Tumor Necrosis Factor-alpha.	J Interferon Cytokine Res 1995 Aug;15(8):677-84
serum tumorlytic factor	0	*Tumor Necrosis Factor-alpha Cytotoxins.	Immunol Lett 1995 May;46(1-2):101-6
pirfenidone	53179-13-8	Pyridones Tumor Necrosis Factor-alpha/antagonists & inhibitors. Pharma Action* Analgesics ; Anti-Inflammatory Agents, Non-Steroidal ; Antineoplastic Agents	J Lab Clin Med 1995 Jun;125(6):779-85
CGP 47969A	0	*Piperazines Interleukin-1/antagonists & inhibitors Cytokines/antagonists & inhibitors Tumor Necrosis Factor-alpha/antagonists & inhibitors Interleukin-6/antagonists & inhibitors.	J Rheumatol 1994 Nov;21(11):1992-7
PEG-modified tumor necrosis factor-alpha	0	Polyethylene Glycols Tumor Necrosis Factor-alpha Drug Carriers.	Jpn J Cancer Res 1994 Dec;85(12):1185-8
58 kDa tumor necrosis factor-inducing protein, Mycobacterium tuberculosis	0	Bacterial Proteins Tumor Necrosis Factor-alpha.	Infect Immun 1993 Feb;61(2):627-32
TNFAIP3 protein, human	EC 6.3.2.19	Nuclear Proteins Intracellular Signaling Peptides and Proteins Tumor Necrosis Factor-alpha Zinc Fingers Ubiquitin-Protein Ligases.	J Biol Chem 1992 Sep 5;267(25):17971-6
tumor necrosis factor (1-26)	0	Peptide Fragments Tumor Necrosis Factor-alpha.	Cytokine 1992 Jul;4(4):313-9
TNFAIP6 protein, human	0	*Cell Adhesion Molecules Tumor Necrosis Factor-alpha.	J Cell Biol 1992;116(2):545

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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