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Tyrocidine

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Definition: An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.     
Pharmacological Action Anti-Bacterial Agents; Anti-Infective Agents, Local 		Other names Tyrocidines; Rapicidin; Brevicidin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tyrocidine thioesterase  EC 3.1.-   *Esterases *Tyrocidine. Bioorg Med Chem Lett. 2002 Mar 25;12(6):989-92
7-ornithine-tyrocidine A  79774-99-5 Tyrocidine A, 10-L-ornithine-, dihydrochloride  Tyrocidine/*analogs & derivatives. Int J Pept Protein Res 1981;18(2):127
6-valine-tyrocidine A  79774-98-4 Tyrocidine A, 9-L-valine-, monohydrochloride  Tyrocidine/*analogs & derivatives. Int J Pept Protein Res 1981;18(2):127

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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