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Monophenol Monooxygenase

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Definition: An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and oxygen to yield L-dopa, dopaquinone, and water. It is a copper protein that acts also on catechols, catalyzing some of the same reactions as CATECHOL OXIDASE. EC 1.14.18.1.  /defic: consider also ALBINISM   
See Also Albinism 		Other names Oxidase, Phenol; Oxidase, Dopa; Monooxygenase, Monophenol; Phenoloxidase B; Phenoloxidase A; Phenol Oxidase; Cresolase; Tyrosinase; Phenoloxidase; Dopa Oxidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
morusyunnansin F  0   *Flavonoids Monophenol Monooxygenase/antagonists & inhibitors. J Nat Prod. 2012 Jan 27;75(1):82-7
morusyunnansin E  0   *Flavonoids Monophenol Monooxygenase/antagonists & inhibitors. J Nat Prod. 2012 Jan 27;75(1):82-7
5-hydroxy-4-oxo-4H-pyran-2-yl methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate  0   *Benzopyrans *Pyrones Monophenol Monooxygenase/antagonists & inhibitors. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7466-9.
zibuganshenfang  0   *Drugs, Chinese Herbal Monophenol Monooxygenase/drug effects Vitiligo/drug therapy. Zhongguo Zhong Yao Za Zhi. 2011 Sep;36(18):2567-70
ethyl-alpha-D-glucopyranoside  0   *Glucosides Monophenol Monooxygenase/antagonists & inhibitors. J Sci Food Agric. 2011 Jul;91(9):1541-7
hibiscetin heptamethyl ether  0   *Flavones Monophenol Monooxygenase/antagonists & inhibitors. Nat Prod Res. 2011 Apr;25(7):750-3
2,6-dimethoxy-4-hydroxyacetophenone  0   *Acetophenones Monophenol Monooxygenase/antagonists & inhibitors. Nat Prod Res. 2011 Apr;25(7):750-3
5,2',4'-trihydroxy-2',2'-dimethylchromene(6,7-5',6')flavanone  0   *Flavanones Monophenol Monooxygenase/antagonists & inhibitors. Bioorg Med Chem 2011 Jun 1;19(11):3474-82
4-hydroxybenzyl 2,4-dihydroxybenzoate  0   *Salicylic Acids Monophenol Monooxygenase/antagonists & inhibitors. Bioorg Med Chem 2011 Feb 1;19(3):1167-71
7-phloroeckol  0   *Dioxins Monophenol Monooxygenase/antagonists & inhibitors. J Agric Food Chem. 2009 May 27;57(10):4124
rubasperone B  0   *Naphthalenes *Pyrones alpha-Glucosidases/antagonists & inhibitors Monophenol Monooxygenase/antagonists & inhibitors. Planta Med. 2010 Nov;76(16):1888-91
rubasperone A  0   *Naphthalenes *Pyrones alpha-Glucosidases/antagonists & inhibitors Monophenol Monooxygenase/antagonists & inhibitors. Planta Med. 2010 Nov;76(16):1888-91
alpha-thujaplicin  0   *Monoterpenes Tropolone/*analogs & derivatives Monophenol Monooxygenase/antagonists & inhibitors. Biol Pharm Bull 2001 Jun;24(6):607-11
3,4'-dihydroxy-3',5'-dimethoxybiphenyl-4-carboxylic acid  0   *Biphenyl Compounds *Salicylic Acids Monophenol Monooxygenase/antagonists & inhibitors. Bioorg Med Chem 2010 Sep 15;18(18):6708-14
N-formylanonaine  0   *Aporphines Monophenol Monooxygenase/antagonists & inhibitors. Bioorg Med Chem 2010 Jul 15;18(14):5241-7
5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol  0   *Naphthols Pyrogallol/*analogs & derivatives Monophenol Monooxygenase/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Aug 15;20(16):4882-4
TYRosinase family member 2, C elegans  EC 1.14.18.1   *Monophenol Monooxygenase *Caenorhabditis elegans Proteins. Nature. 2010 Jun 3;465(7298):577-83
4-hydroxy-2,6-dimethyl-5,6-dihydro-4H-1,3-thiazine  0   *Thiazines Monophenol Monooxygenase/antagonists & inhibitors. J Pharm Pharmacol 2009 Dec;61(12):1657-63
1',3'-dilinolenoyl-2'-linoleoylglycerol  0   *Triglycerides Monophenol Monooxygenase/antagonists & inhibitors. J Microbiol Biotechnol 2009 Jul;19(7):681-4
cinnamaldehyde thiosemicarbazone  0   *Thiosemicarbazones Monophenol Monooxygenase/antagonists & inhibitors. J Agric Food Chem 2009 Jun 24;57(12):5518-23
6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione  0   *Quinazolines Monophenol Monooxygenase/antagonists & inhibitors. Arch Pharm Res. 2008 Oct;31(10):1363-8
2-butyl-5-hydroxyphenyl dihydrocaffeate  0   *Caffeic Acids Monophenol Monooxygenase. J Pharm Pharmacol 2008 Mar;60(3):343-8
3-(2,4-dihydroxyphenyl)propionic acid  0   *Phenylpropionates Monophenol Monooxygenase/antagonists & inhibitors. J Med Chem 2007 May 31;50(11):2676-81
3,5-dihydroxystilbene  0   *Stilbenes Monophenol Monooxygenase/antagonists & inhibitors. Biochem Biophys Res Commun 2006 Apr 21;342(4):1147-51
17-ethyl-17-hydroxyandrost-4-en-3-one  0   Testosterone/*analogs & derivatives Monophenol Monooxygenase/antagonists & inhibitors. Steroids 2005 Nov;70(12):798-802
5,7,4',5'',7'',3''',4'''-heptahydroxy(3-8'')biflavanone  0   *Flavanones Monophenol Monooxygenase/antagonists & inhibitors. Biosci Biotechnol Biochem 2005 Jan;69(1):197-201
5,7,4',5'',7'',3''',4'''-heptahydroxyflavanone(3-8'')flavone  0   *Flavanones *Flavones Monophenol Monooxygenase/antagonists & inhibitors. Biosci Biotechnol Biochem 2005 Jan;69(1):197-201
polyhemoglobin-tyrosinase  0   *Hemoglobins *Monophenol Monooxygenase. Artif Cells Blood Substit Immobil Biotechnol 2004 May;32(2):293-302
3,7,4'-trihydroxyflavone  0   *Flavonoids Monophenol Monooxygenase/antagonists & inhibitors. Biochemistry (Mosc) 2003 Apr;68(4):487-91
barbarin  0   *Oxazoles Monophenol Monooxygenase/antagonists & inhibitors. Planta Med 1999 Dec;65(8):683-6
2-hydroxy-4-methoxybenzaldehyde  673-22-3   *Benzaldehydes Rhus Monophenol Monooxygenase/antagonists & inhibitors Anacardiaceae Asclepiadaceae. Planta Med 1999 Feb;65(1):19-22
methyl gentisate  0   *Hydroxybenzoic Acids Cosmetics Skin Pigmentation/drug effects Monophenol Monooxygenase/antagonists & inhibitors. Biochem Pharmacol 1999 Mar15;57(6):663-72
2-O-(5-hydroxy-4H-pyran-4-one-2-methyl)ascorbic acid  0   Ascorbic Acid/*analogs & derivatives Monophenol Monooxygenase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1996 Sep;44(9):1647-55
3-O-((tocopheryloxy)-2-hydroxypropyl)ascorbic acid  0   Ascorbic Acid/*analogs & derivatives Monophenol Monooxygenase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1996 Sep;44(9):1647-55
oscillapeptin G  0   *Peptides, Cyclic Monophenol Monooxygenase/antagonists & inhibitors. J Nat Prod 1996 Jan;59(1):90-2
3,4',5-trihydroxystilbene-4'-O-(6''-O-galloyl)glucopyranoside  80446-63-5   *Glucosides *Stilbenes Melanins/antagonists & inhibitors Monophenol Monooxygenase/antagonists & inhibitors. Planta Med 1995 Oct;61(5):425-8
3,4',5-trihydroxystilbene-4'-O-(2''-O-galloyl)glucopyranoside  105304-51-6   *Glucosides *Stilbenes Melanins/antagonists & inhibitors Monophenol Monooxygenase/antagonists & inhibitors. Planta Med 1995 Oct;61(5):425-8
pseudostellarin H  0   *Peptides, Cyclic Monophenol Monooxygenase/antagonists & inhibitors. J Nat Prod 1995 Jun;58(6):943-7
phenol oxidase inhibitor, housefly  0   *Peptides Monophenol Monooxygenase/antagonists & inhibitors Insect Proteins. Proc Natl Acad Sci U S A 1995 Mar 28;92(7):2964-8
5-(8,11,14-pentadecatrienyl)resorcinol  15071-61-1   *Resorcinols Monophenol Monooxygenase/antagonists & inhibitors. J Nat Prod 1994 Apr;57(4):545-51
S-(2-(N,N-diisopropylamino)ethyl)isothiourea  142620-95-9   Dimaprit/*analogs & derivatives Monophenol Monooxygenase/antagonists & inhibitors. Biochem Biophys Res Commun 1994 Jun 15;201(2):687-93
gamma-glutaminyl-4-hydroxy-3-iodobenzene  147139-63-7   *Phenols Glutamine/*analogs & derivatives Monophenol Monooxygenase. Biochem Pharmacol 1993 Jan 26;45(2):473-81
N-acetyl-6-hydroxytryptophan oxidase  EC 1.14.18.-   *Monophenol Monooxygenase. J Gen Microbiol 1990;136(Pt 9):1725

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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