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Glucuronosyltransferase

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Definition: A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.  /defic: consider also CRIGLER-NAJJAR SYNDROME & coord with BILIRUBIN /metab (NIM)    Other names p Nitrophenyl UDP Glucuronosyltransferase; UDP-Glucuronyltransferase, Bilirubin; UDP-Glucuronosyltransferase, p-Nitrophenyl; UDP-Glucuronosyltransferase, Estrogen; UDP-Glucuronosyltransferase, Androsterone; UDP-Glucuronosyltransferase, 17 beta-Hydroxysteroi; UDP Glucuronyltransferase, 7-Hydroxycoumarin; UDP Glucuronic Acid 3 O beta D Galactosyl D Galact; Transferase, UDP Glucuronyl; Transferase, Glucuronic; Glucuronyltransferase, Morphine; Glucuronyltransferase, Estrone; Glucuronyltransferase, 7-Hydroxycoumarin UDP; Glucuronyl Transferase, UDP; Glucuronosyltransferase, UDP; Estrogen UDP Glucuronosyltransferase; Bilirubin UDP Glucuronyltransferase; Androsterone UDP Glucuronosyltransferase; 7 Hydroxycoumarin UDP Glucuronyltransferase; 4 Nitrophenol UDP Glucuronosyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
galacturonosyltransferase 7, Arabidopsis  EC 2.4.1.17   *Glucuronosyltransferase *Arabidopsis Proteins. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20225-30
UGT2B10 protein, human  EC 2.4.1.-   *Glucuronosyltransferase. Drug Metab Dispos. 2010 May;38(5):863-70
UGT3A1 protein, human  EC 2.4.1.-   *Glucuronosyltransferase *N-Acetylglucosaminyltransferases. J Biol Chem 2008 Dec 26;283(52):36205-10
UGT2A3.2 protein, human  EC 2.4.1.17   *Glucuronosyltransferase. Mol Pharmacol. 2008 Sep;74(3):744-54
UGT1A7 protein, human  EC 2.4.1.17   *Glucuronosyltransferase. Eur J Clin Pharmacol 2006 Oct;62(10):829-37
HAS1 protein, human  EC 2.4.1.17   *Glucuronosyltransferase. J Biol. Chem 1996 Sep 20;271(38):23395-9
FRA8 protein, Arabidopsis  EC 2.4.1.17   *Glucuronosyltransferase *Arabidopsis Proteins. Plant Cell 2005 Dec;17(12):3390-408
UGT1A5 protein, human  EC 2.4.1.17   *Glucuronosyltransferase. J Pharmacol Exp Ther 2005 Dec;315(3):1143-9
UDP glucuronosyltransferase 1A2, rat  EC 2.4.1.-   *Glucuronosyltransferase. J Biochem (Tokyo) 2005 Sep;138(3):313-25
UGT2B17 protein, human  EC 2.4.1.17   *Glucuronosyltransferase. Br J Haematol. 2005 Apr;129(2):221-8
Ugt1a1 protein, rat  0   *Glucuronosyltransferase.
UGT2B7 protein, human  EC 2.4.1.-   *Glucuronosyltransferase. Breast Cancer Res 2004;6(5):R488-98
Has3 protein, mouse  EC 2.4.1.-   *Glucuronosyltransferase.
Has3 protein, rat  EC 2.4.1.-   *Glucuronosyltransferase.
HAS3 protein, Xenopus  EC 2.4.1.-   *Glucuronosyltransferase *Xenopus Proteins. Matrix Biol 2003 Nov;22(6):511-7
Has2 protein, mouse  EC 2.4.1.-   *Glucuronosyltransferase.
Has2 protein, rat  EC 2.4.1.-   *Glucuronosyltransferase.
Has2 protein, Xenopus  EC 2.4.1.-   *Xenopus Proteins *Glucuronosyltransferase.
has2 protein, zebrafish  EC 2.4.1.-   *Glucuronosyltransferase *Zebrafish Proteins.
UGT2B4 protein, human  EC 2.4.1.17   *Glucuronosyltransferase.
bilirubin uridine-diphosphoglucuronosyl transferase 1A10  EC 2.4.1.-   *Glucuronosyltransferase. Cancer. 2003 Aug 15;98(4):872-80
B3GAT2 protein, human  EC 2.4.1.135   *Glucuronosyltransferase. J Hum Genet 2002;47(12);677-80
GlcAT-P protein, Drosophila  EC 2.4.1.17   *Glucuronosyltransferase *Drosophila Proteins. J Biol Chem 2003 Mar 14;278(11):9116-24
GlcAT-S protein, Drosophila  EC 2.4.1.17   *Glucuronosyltransferase *Drosophila Proteins. J Biol Chem 2003 Mar 14;278(11):9116-24
UDP-glucuronosyltransferase 2B15, human  EC 2.4.1.17   *Glucuronosyltransferase. Drug Metab Dispos 2002 Nov;30(11):1257-65
chondroitin sulfate glucuronyltransferase  EC 2.4.1.17   *Glucuronosyltransferase. J Biol Chem 2002 Oct 11;277(41):38179-88
UDP-glucuronosyltransferase, UGT1A8  EC 2.4.1.17   *Glucuronosyltransferase. Biochem Pharmacol 2002 Feb 15;63(4):767-75
UDP-glucuronosyltransferase 2B22  EC 2.4.1.-   *Glucuronosyltransferase. Mol Pharmacol 2001 Nov;60(5):1040-8
UDP-glucuronosyltransferase 2B21  EC 2.4.1.-   *Glucuronosyltransferase. Mol Pharmacol 2001 Nov;60(5):1040-8
alpha-1,4-galacturonosyltransferase  EC 2.4.1.17   *Glucuronosyltransferase. Plant Physiol 2001 Sep;127(1):360-71
glycosaminoglycan glucuronyltransferase I  EC 2.4.1.-   *Glycosaminoglycans *Glucuronosyltransferase. Biochem J 2001 Sep 15;358(Pt 3):539-46
GelK protein, Sphingomonas paucimobilis  EC 2.4.1.-   *Bacterial Proteins *Glucuronosyltransferase. Biochem J 2001 Sep 1;358(Pt 2):457-64
UDP-glucuronosyltransferase, UGT2B28  EC 2.4.1.-   *Glucuronosyltransferase. Biochemistry 2001 Apr 3;40(13):3869-81
UDP-glucuronosyltransferase isoenzyme 1.1  EC 2.4.1.-   *Glucuronosyltransferase. Am J Gastroenterol 2001 Mar;96(3):910-3
bilirubin uridine-diphosphoglucuronosyl transferase 1A1  EC 2.4.1.-   *Glucuronosyltransferase. Pharmacogenetics 2000Aug;10(6):539-44
UDP-glucuronosyltransferase 1A9  EC 2.4.1.17   *Glucuronosyltransferase. Life Sci 2000 Oct 6;67(20):2473-84
UDP-glucuronate baicalein 7-O-glucuronosyltransferase  EC 2.4.1.-   *Glucuronosyltransferase. Phytochemistry 2000 Mar;53(5):533-8
UDP-glucuronosyltransferase, UGT2B7  EC 2.4.1.-   *Glucuronosyltransferase. J Steroid Biochem Mol Biol 1999 Jul-Aug;70(1-3):101-8
UDP-glucuronosyltransferase, UGT1A3  EC 2.4.1.-   *Glucuronosyltransferase. J Steroid Biochem Mol Biol 1999 Jul-Aug;70(1-3):101-8
galactoside beta-1,3-glucuronyltransferase  EC 2.4.1.-   *Glucuronosyltransferase. J Biol Chem 1999Jun 11;274(24):17115-22
thyroxine-UDP-glucuronosyltransferase  EC 2.4.1.-   *Glucuronosyltransferase. Carcinogenesis 1999 Jan;20(1):173-6
UGT2B11 protein, human  EC 2.4.1.-   *Glucuronosyltransferase. Biochem Biophys Res Commun 1998 Jul 9;248(1):44-50
galactosylgalactoylxylosylprotein 3-beta-glucuronosyltransferase  EC 2.4.1.135   *Glucuronosyltransferase. J Biol Chem 1998 Mar 20;273(12):6615-8
UDP-glucuronosyltransferase, UGT2B9  EC 2.4.1.-   *Glucuronosyltransferase. J Mol Biol 1998 Feb 6;275(5):785-94
UDP-glucuronosyltransferase, UGT1A6  EC 2.4.1.-   *Glucuronosyltransferase. Arch Biochem Biophys 1998 Feb 1;350(1):72-8
UDP-glucuronosyltransferase, UGT1A7  EC 2.4.1.17   *Glucuronosyltransferase. Arch Biochem Biophys 1997 Aug 15;344(2):357-64
HAS3 protein, human  EC 2.4.1.-   *Glucuronosyltransferase. J Biol Chem 1997 Apr 4;272(14):8957-61
HAS2 protein, human  EC 2.4.1.-   *Glucuronosyltransferase. J Biol Chem 1996 Sep 20;271(38):22945-8; J Biol Chem 1996 Sep 20;271(38):23400-6
5'-O-(((2-decanoyl-amino-3-hydroxy-3-phenylpropyloxycarbonyl)amino)sulfonyl)-2',3'-O-isopropylideneuridine  149992-49-4   *Propanolamines Uridine/*analogs & derivatives Glucuronosyltransferase/antagonists & inhibitors. Biochim Biophys Acta 1995 Jan 18;1243(1):9-14
cytosine-UDP-glucuronosyltransferase  EC 2.4.1.-   *Glucuronosyltransferase. J Bacteriol 1994 Mar;176(5):1282-6
phenol glucuronosyltransferase  EC 2.4.1.-   *Glucuronosyltransferase. J Biol Chem 1992 Feb 15;267(5):3257-61
2,2,2-triphenylethyl-UDP  127424-42-4   Uridine Diphosphate/*analogs & derivatives Glucuronosyltransferase/antagonists & inhibitors. Mol Pharmacol 1991;40(2):316
glucuronyltransferase GlcAT-1  EC 2.4.1.-   *Glucuronosyltransferase. J Biol Chem 1991;266(8):5238
triphenylacetic acid  595-91-5   *Phenylacetates Glucuronosyltransferase/antagonists & inhibitors. Biochim Biophys Acta 1986;883(2):190
4-methylumbelliferone glucuronyltransferase  EC 2.4.1.-   *Glucuronosyltransferase. Biochem J 124(1):19;1971
hyaluronan synthase  EC 2.4.1.212   *Glucuronosyltransferase. Biochem J 162:539;1977; Biochem Pharmacol 27(11):1551;1978; Biochim Biophys Acta 338:352;1974; FEBS Lett 1980;111(2):295; J Cell Physiol 86(1):121;1975; J Cell Physiol 87(2):189;1975; J Cell Physiol 91:323;1977; J Cell Physiol 91:79;1977; Prostaglandins 14(5):983;1977
bilirubin glucuronoside glucuronosyltransferase  EC 2.4.1.95   *Glucuronosyltransferase. Biochem Pharmacol 26:902;1977; Biomedicine 25(2):61;1976; Eur J Biochem 29(3):433;1972; J Clin Invest 62(1):191;1978; Med Chir Dig 7(2):149;1978

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