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Uncoupling Agents

More information in Books or onNLM PubMed
Definition: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.  enzyme inhib   
See Also Ionophores
Examples Proton Ionophores 		Other names Agents, Uncoupling
Substances having this pharmacologic action: hedolit; ellipticine; bathophenanthroline; SF 6847; picric acid; mitochondrial uncoupling protein 3; Chlorphenamidine; Alamethicin; Aurovertins; Rotenone; Rutamycin; Tetraphenylborate; Venturicidins; 2,4-Dinitrophenol; Oligomycins; Pentachlorophenol; Dinitrophenols; Dicumarol; glyphosate; bis(1,10-phenanthroline)copper(2+) ion; mitochondrial uncoupling protein 2
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DIO 9  11006-20-5   Organic Chemicals Uncoupling Agents.
mitochondrial uncoupling protein  0   *Ion Channels *Mitochondrial Proteins Mitochondria Uncoupling Agents Adipocytes. J Biol Chem 1983;258(11):6675
carbonyl cyanide phenylhydrazone  306-18-3 Propanedinitrile, (phenylhydrazono)  Carbonyl Cyanide m-Chlorophenyl Hydrazone/*analogs & derivatives Uncoupling Agents. Biochem J 156(3):481;1976; Biochem J 156(3):493;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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