encyclopedia of medical concepts
ψ 
ψ 

Valproic Acid

More information in Books or onNLM PubMed
Definition: A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.     
Pharmacological Action Anticonvulsants; Antimanic Agents; Enzyme Inhibitors; GABA Agents 		Other names Sodium Valproate; Divalproex; Dipropyl Acetate; Valproate, Sodium; Valproate, Semisodium; Valproate, Magnesium; Valproate, Calcium; Sodium, Valproate; Sodium, Divalproex; Acid, Valproic; Acid, Propylisopropylacetic; Acetate, Dipropyl; 2 Propylpentanoic Acid; Vupral; Valproic Acid, Sodium Salt (2:1); Valproate Sodium; Semisodium Valproate; Propylisopropylacetic Acid; Magnesium Valproate; ValproateDrugs* : VALPROIC ACID; DIVALPROEX; STAVZOR; DIVALPROEX SODIUM; DEPAKENE; DEPAKOTE CP; DEPAKOTE; DEPAKOTE ER; VALPROATE SODIUM; DEPACON
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
sec-butyl-propylacetamide  0   *Amides Valproic Acid/*analogs & derivatives Anticonvulsants Seizures/drug therapy. Epilepsia. 2012 Jan;53(1):134-46
2,4-diene-valproic acid  0   Valproic Acid/*analogs & derivatives. J Appl Toxicol. 2010 Nov;30(8):775-8
Propylisopropylactic Acid  0   Valproic Acid/*analogs & derivatives.
Valproic acid antenatal infection  0   *Abnormalities, Drug-Induced Valproic Acid/adverse effects.
ACS33 compound  0   Valproic Acid/*analogs & derivatives Histone Deacetylases/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Mar 15;18(6):1893-7
ACS2 compound  0   Valproic Acid/*analogs & derivatives Histone Deacetylases/antagonists & inhibitors. Bioorg Med Chem Lett 2008 Mar 15;18(6):1893-7
pentyl-4-pentynoic acid  0   Valproic Acid/*analogs & derivatives. Drug Metab Dispos. 2006 Apr;34(4):612-20
S-2-pentyl-4-pentynoic hydroxamic acid  0   Valproic Acid/*analogs & derivatives. Drug Metab Dispos. 2006 Apr;34(4):612-20
3-keto-valproate  0   *Ketones Valproic Acid/*analogs & derivatives. Clin Chim Acta. 2003 Aug;334(1-2):145-51
DP-VPA  0   Valproic Acid/*analogs & derivatives. Curr Opin Investig Drugs 2002 Jun;3(6):921-3
3-oxovalproyl-CoA  0   *Acyl Coenzyme A Valproic Acid/*analogs & derivatives. Biochem J 2002 Mar 15;362( Pt 3):755-60
3-aminopentanoic acid  0   *Valproic Acid. J Nat Prod 2002 Jan;65(1):29-31
pentyl-4-yn-valproic acid  0   Valproic Acid/*analogs & derivatives. J Neurochem 2001 Aug;78(4):704-14
Epilim  0   *Valproic Acid. Aust N Z J Psychiatry 2000 Feb;34(1):172
dimethylenexylitol valproate  0   Valproic Acid/*analogs & derivatives Xylitol/*analogs & derivatives. Epilepsy Res 1998 Nov;32(3):345-55
glucose valproate  0   Glucose/*analogs & derivatives Valproic Acid/*analogs & derivatives. Epilepsy Res 1998 Nov;32(3):345-55
valproic acid pivaloyl oxymethyl ester  0   Valproic Acid/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 1998 Apr-Jun;23(2):223-9
delta(3) valproic acid  0   Valproic Acid/*analogs & derivatives. Arch Biochem Biophys 1998 Aug 1;356(1):63-70
N,N'-bis-(2-propylpentanoyl)-1,3-propanediamine  0   Valproic Acid/*analogs & derivatives. Arch Pharm (Weinheim) 1997 Oct;330(9-10):273-6
N,N'-bis-(2-propylpentanoyl)-1,2-ethanediamine  0   Valproic Acid/*analogs & derivatives. Arch Pharm (Weinheim) 1997 Oct;330(9-10):273-6
N-(2-propylpentanoyl)urea  0   Urea/*analogs & derivatives Valproic Acid/*analogs & derivatives. Res Commun Mol Pathol Pharmacol 1997 Aug;97(2):151-64
3-hydroxymethylphenytoin valproic acid ester  0   Valproic Acid/*analogs & derivatives. Arch Pharm (Weinheim) 1996 Dec;329(12):554-6
2-fluoro-2-propyl-4-pentenoic acid  0   Valproic Acid/*analogs & derivatives. Chem Res Toxicol 1995 Jul-Aug;8(5):671-82
encorat  0   Valproic Acid/*analogs & derivatives. Zh Nevropatol Psikhiatr Im S S Korsakova 1994;94(6):28-33
5-hydroxyvalproate  53660-23-4   Valproic Acid/*analogs & derivatives. Mater Med Pol 1994 Jan-Mar;26(1):29-32
4-hydroxyvalproate  60113-82-8   Valproic Acid/*analogs & derivatives. Mater Med Pol 1994 Jun-Mar;26(1):29-32
3-aminovalproic acid  0   Valproic Acid/*analogs & derivatives. Pharm Res 1994 Apr;11(4):571-4
4-aminovalproic acid  0   Valproic Acid/*analogs & derivatives. Pharm Res 1994 Apr;11(4):571-4
glyceryl trivalproate  146356-76-5   *Triglycerides Valproic Acid/*analogs & derivatives. Biopharm Drug Dispos 1993 Jan;14(1):51-9
1,4-butanediol divalproate  77656-73-6   *Butylene Glycols Valproic Acid/*analogs & derivatives. Biopharm Drug Dispos 1993 Jan;14(1):51-9
1,3-dihexadecanoylamino-2-valproyl-propan-ol  138404-96-3   Valproic Acid/*analogs & derivatives. J Pharm Pharmacol 1991 Nov 43(11):815-6
valproyl-adenylic acid  140233-88-1   Adenosine Monophosphate/*analogs & derivatives Valproic Acid/*analogs & derivatives. J Biol Chem 1992 Feb 15;267(5):3143-46
2-n-propyl-3-oxopentanoic acid  60113-81-7   Valproic Acid/*analogs & derivatives. Drug Metab Dispos 1991;19(4):823
lysine valproate  86827-89-6   Lysine/*analogs & derivatives Valproic Acid/*analogs & derivatives. Farmaco (Prat) 1988;43(9):291
valproic acid hydroxamate  106132-78-9   Valproic Acid/*analogs & derivatives. Biomed Environ Mass Spectrom 1986;13(11):599
valproic acid glucuronide  60113-83-9   Valproic Acid/*analogs & derivatives. Drug Metab Dispos 1984;12(2):247
3-hydroxypropylpentanoic acid ethyl ester  80173-34-8 Pentanoic acid, 3-hydroxy-2-propyl-, ethyl ester  Valproic Acid/*analogs & derivatives. Can J Neurol Sci 1981;8(3):259
3-ketovalproic acid ethyl ester  67244-24-0   Valproic Acid/*analogs & derivatives. Can J Neurol Sci 1981;8(3):259
valproic acid ethyl ester  17022-31-0   Valproic Acid/*analogs & derivatives. Can J Neurol Sci 1981;8(3):259
valpronic acid  0   Valproic Acid/*analogs & derivatives. Arzneim Forsch 1980;30(8):1213
valproate phenacyl ester  71683-26-6   Valproic Acid/*analogs & derivatives. Clin Chem 1980;26(11):1528
dipropylacetamide  2430-27-5 2-ethylvaleramide  Valproic Acid/*analogs & derivatives.
Pharma Action Anticonvulsants 		Acta Psychiatr Belg 1979;79(2):210; Acta Psychiatr Belg 76(3):458;1976; Actas Luso Esp Neurol Psiquiatr 6(3):249;1978; Ann Med Psychol 2(5):915;1977; Drug Interfer Drug Measure Clin Chem QV38 I602:186;1975c; Encephale (Paris) 4(3):251;1978

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy