Variant Surface Glycoproteins (definition)

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Variant Surface Glycoproteins, Trypanosoma

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Definition: Glycoproteins attached to the surface coat of the trypanosome. Many of these glycoproteins show amino acid sequence diversity expressed as antigenic variations. This continuous development of antigenically distinct variants in the course of infection ensures that some trypanosomes always survive the development of immune response to propagate the infection.

/drug eff /ultrastruct permitted; DF: VSG TRYPAN

Other names SSP-4; Trypanosoma Variant Surface Coat Glycoproteins; Surface Variant Glycoproteins, Trypanosoma; VSG 221; VSG 118; VSG 117

Substance	CAS Registry & name	Categories	Source
glycoprotein GP82, Trypanosoma cruzi	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins.	Acta Trop 2008 Jan;105(1):87-91
MVAT4 protein, Trypanosoma brucei	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins.	J Biol Chem 1999 Jun 11;274(24):16876-83
ESAG 1 protein, Trypanosoma	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins.	J Biol Chem 1996 Apr 19;271(16):9771-7
BENat 1.3 protein, Trypanosoma congolense	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins.	Eur J Biochem 1994 Aug 1;223(3):813-21
BENat 1 protein, Trypanosoma congolense	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins.	Eur J Biochem 1994 Aug 1;223(3):813-21
BENat 1.2 protein, Trypanosoma congolense	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins.	Eur J Biochem 1994 Aug 1;223(3):813-21
GM6 protein, Trypanosoma brucei	148168-22-3	*Variant Surface Glycoproteins, Trypanosoma Trypanosoma brucei gambiense.	Parasitology 1992 Feb;104 Pt 1:111-20
trypomastigote specific surface antigen	138820-03-8	*Variant Surface Glycoproteins, Trypanosoma Trypanosoma cruzi.	Mol Biochem Parasitol 1991;46(2):189
AnTaT 1.1 antigen, Trypanosoma brucei	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins.	EMBO J 1990;9(4):1035
glycoprotein GP90, Trypanosoma cruzi	0	Variant Surface Glycoproteins, Trypanosoma Protozoan Proteins Trypanosoma cruzi.	Philos Trans R Soc Lond Biol 1984;307(1131):63

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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