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Vasoactive Intestinal Peptide

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Definition: A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE).     
Pharmacological Action Gastrointestinal Agents; Neuroprotective Agents; Vasodilator Agents 		Other names Polypeptide, Vasoactive Intestinal; Peptide, Vasointestinal; Peptide, Vasoactive Intestinal; Intestinal Polypeptide, Vasoactive; Intestinal Peptide, Vasoactive; Vasointestinal Peptide; Vasoactive Intestinal Polypeptide; VIP (Vasoactive Intestinal Peptide)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RO5024118  0   *Vasoactive Intestinal Peptide. Br J Pharmacol. 2010 Nov;161(6):1329-42
vasoactive intestinal peptide-glycyl-arginyl-arginine, arginyl(15,20,21)-leucyl(17)-alanyl(24,25)-desasparagyl(28)  0   Vasoactive Intestinal Peptide/*analogs & derivatives. Int J Pharm 2011 May 30;410(1-2):54-60
vasoactive intestinal peptide, gamma-Gln(16)-diaminopropane  0   Vasoactive Intestinal Peptide/*analogs & derivatives. Amino Acids 2010 Aug;39(3):661-70
techentium 99m tricarbonyl VD5 peptide  0   *Organotechnetium Compounds Vasoactive Intestinal Peptide/*analogs & derivatives. Appl Radiat Isot 2006 Apr;65(4):382-6
technetium 99m tricarbonyl VD4 peptide  0   *Organotechnetium Compounds Vasoactive Intestinal Peptide/*analogs & derivatives. Appl Radiat Isot 2006 Apr;65(4):382-6
technetium 99m tricarbonyl VP05 peptide  0   *Organotechnetium Compounds Vasoactive Intestinal Peptide/*analogs & derivatives. Appl Radiat Isot 2006 Apr;65(4):382-6
vasoactive intestinal peptide, N-succinimidyl 4-fluorobenzoate-Arg(8,15,21)-Leu(17)  0   Vasoactive Intestinal Peptide/*analogs & derivatives Fluorine Radioisotopes. Chem Biol Drug Des 2006 Dec;68(6):319-25
(Bz2-K24)-vasoactive intestinal peptide  0   *Vasoactive Intestinal Peptide. Ann N Y Acad Sci 2006 Jul;1070:575-80
vasoactive intestinal peptide-GRR, Arg(15,20,21)-Leu(17)  0   Vasoactive Intestinal Peptide/*analogs & derivatives. Life Sci 2006 Jun 6;79(2):138-43
vasoactive intestinal polypeptide, N-hexanoyl  0   *Vasoactive Intestinal Peptide. Peptides 2004 Dec;25(12):2079-86
TP3982  0   *Vasoactive Intestinal Peptide. J Nucl Med 2004 Aug;45(8);1381-9
JV 1-53  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors Vasoactive Intestinal Peptide/antagonists & inhibitors. Int J Cancer 2002 Apr 1;98(4):624-9
JV 1-52  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors Vasoactive Intestinal Peptide/antagonists & inhibitors. Int J Cancer 2002 Apr 1;98(4):624-9
stearyl-Nle(17)-neurotensin(6-11)VIP(7-28)  0   *Neurotensin *Vasoactive Intestinal Peptide. Cancer 2001 Oct 15;92(8):2172-80
aviptadil  0   *Phentolamine *Vasoactive Intestinal Peptide Drug Combinations Erectile Dysfunction. Curr Opin Investig Drugs 2001 Apr;2(4):545-9
vasoactive intestinal peptide (1-7)-growth hormone-releasing factor (8-27), lysyl(15)-arginyl(16)-leucyl(27)  0   Growth Hormone-Releasing Hormone Vasoactive Intestinal Peptide Receptors, Vasoactive Intestinal Peptide/agonists. Eur J Neurosci 2001 Feb;13(4):839-43
vasoactive intestinal peptide (6-23)  0   *Peptide Fragments *Vasoactive Intestinal Peptide. Dev Biol 2000 Oct 15;226(2):1035-41
vasoactive intestinal peptide (1-7)-GRF (8-27), Lys(15)-Arg(16)-Leu(27)  0   *Peptide Fragments Vasoactive Intestinal Peptide. Am J Physiol Gastrointest Liver Physiol 2000 Jan;278(1):G64-G74
iodinated vasoactive intestinal peptide  0   *Vasoactive Intestinal Peptide Iodine Radioisotopes. Nucl Med Biol 1999 Nov;26(8):931-6
TP 3654  0   *Oligopeptides *Vasoactive Intestinal Peptide. J Nucl Med 1999 Feb;40(2):352-60
vasoactive intestinal peptide (6-28)  0   *Peptide Fragments *Vasoactive Intestinal Peptide. J Neurosci 1998 Jul 15;18(14):5285-93
Arg(15,20,21)-Leu(17)-VIP-Gly-Lys-Arg-NH2  0   *Vasoactive Intestinal Peptide. Peptides 1998;19(3):593-7
PG 97-269  0   *Peptide Fragments Vasoactive Intestinal Peptide Vasoactive Intestinal Peptide/antagonists & inhibitors. Peptides 1997;18(10):1555-60
Ro 25-1392  0   *Peptides, Cyclic *Vasoactive Intestinal Peptide. J Pharmacol Exp Ther 1997 May;281(2):629-33
vasoactive intestinal peptide (11-28)-NH2  0   *Peptide Fragments *Vasoactive Intestinal Peptide. Pept Res 1996 Nov-Dec;9(6):327-30
vasoactive intestinal peptide, Lys(1)--Pro(2,5)-Leu(17)  0   Vasoactive Intestinal Peptide. Cardiovasc Res 1997 Feb;33(2):392-9
vasoactive intestinal peptide (4-11)  0   *Peptide Fragments *Vasoactive Intestinal Peptide. Dokl Akad Nauk 1996 Aug;349(5):690-3
vasoactive intestinal peptide, Lys(1)-Pro(2,5)-Arg(3,4)-Tyr(6)  0   Vasoactive Intestinal Peptide. J Endocrinol 1996 May;149(2):287-95
vasoactive intestinal peptide, Cys(2)  0   Vasoactive Intestinal Peptide. Adv Exp Med Biol 1995;371A:553-8
Ro 24-9981  0   *Peptides, Cyclic Vasoactive Intestinal Peptide. Am J Physiol 1995 Nov;269(5 Pt 2):H1648-55
vasoactive intestinal peptide, 17-norleucine  0   *Vasoactive Intestinal Peptide. Am J Physiol 1995 Oct;269(4 Pt 1):G584-90
Ro 25-1553  0   *Peptides, Cyclic Vasoactive Intestinal Peptide Receptors, Vasoactive Intestinal Peptide/agonists. J Pharmacol Exp Ther 1994 Sep;270(3):1282-8
vasoactive intestinal peptide, 4-Cl-Phe  0   Vasoactive Intestinal Peptide. Pediatr Res 1994 Apr;35(4 Pt 1):470-3
stearyl-norleucine(17)-vasoactive intestinal peptide  0   *Vasoactive Intestinal Peptide. Endocrinology 1994 May;134(5):2121-5
vasoactive intestinal peptide, (N-Ac-His(1)-Nle(17)-Arg(20,21)-Ala(26))  0   Vasoactive Intestinal Peptide. Proc Natl Acad Sci USA 1993 Apr 1;90(7):2618-22
vasoactive intestinal peptide (1-11)  144119-83-5   *Peptide Fragments *Vasoactive Intestinal Peptide. Mol Pharmacol 1992 Jan;41(1):104-9
vasoactive intestinal peptide, Gly  0   *Protein Precursors *Vasoactive Intestinal Peptide. Biochem Biophys Res Commun 1991;178(1):173
(VIP-neurotensin) hybrid antagonist  125093-93-8   *Neurotensin *Vasoactive Intestinal Peptide Recombinant Fusion Proteins. J Pharmacol Exp Ther 1991;257(3):959
vasoactive intestinal peptide (1-16)  0   *Peptide Fragments Vasoactive Intestinal Peptide. Cancer 1991;67(6):1487
vasoactive intestinal peptide-neurotensin hybrid  0   *Neurotensin *Peptide Fragments *Vasoactive Intestinal Peptide. Endocrinology 1989;125(6):2945
vasoactive intestinal peptide (22-28)  47900-24-3   *Peptide Fragments *Vasoactive Intestinal Peptide. Peptides 1989;10(3):621
vasoactive intestinal peptide, Ac-(Lys(12,14)-Nle(17)-Val(26)-Thr(28))  117811-28-6   Vasoactive Intestinal Peptide. Biochemistry 1989;28(6):2399
vasoactive intestinal peptide, 4-azidobenzoyl  0   *Azides Vasoactive Intestinal Peptide. Biochem J 1988;250(3):679
vasoactive intestinal peptide (7-11)  107531-14-6   *Peptide Fragments *Vasoactive Intestinal Peptide. Ann N Y Acad Sci 1988;527;574
vasoactive intestinal peptide (1-12)  112160-96-0   *Peptide Fragments *Vasoactive Intestinal Peptide Antigens, CD4. Ann N Y Acad Sci 1988;527:574
preprovasoactive intestinal peptide  81032-41-9   *Protein Precursors *Vasoactive Intestinal Peptide. Regul Pept 1988;30(3):199
peptide histidine valine 42  111366-38-2   *Peptide Fragments *Protein Precursors *Vasoactive Intestinal Peptide. J Biol Chem 1987;262(29):14010
vasoactive intestinal peptide precursor  87502-47-4   *Peptide PHI *Protein Precursors *Vasoactive Intestinal Peptide. Proc Natl Acad Sci USA 1987;84(2):605
preprovasoactive intestinal peptide (111-122)  123025-94-5   *Peptide Fragments *Protein Precursors *Vasoactive Intestinal Peptide. Biochem Biophys Res Commun 1986;139(3):1142
vasoactive intestinal peptide, iodo-Tyr(10)-Met sulfoxide(17)  98575-84-9   Vasoactive Intestinal Peptide Iodine Radioisotopes. J Biol Chem 1986;261(12):5320
vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)  102805-45-8   Vasoactive Intestinal Peptide.
Pharma Action Hormone Antagonists 		Am J Physiol 1986;250(4 Pt 1):G553
vasoactive intestinal peptide (10-28)  69856-17-3   *Peptide Fragments *Vasoactive Intestinal Peptide Receptors, Vasoactive Intestinal Peptide/antagonists & inhibitors. Proc Natl Acad Sci USA 1986;83(4):1159

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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