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Verapamil

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Definition: A calcium channel blocker that is a class IV anti-arrhythmia agent.     
Pharmacological Action Anti-Arrhythmia Agents; Calcium Channel Blockers; Vasodilator Agents
Examples Gallopamil
Other names Verapamil Sandoz Brand; Hydrochloride, Verapamil; Iproveratril; Verapamil Hydrochloride; Sandoz Brand of Verapamil; Lekoptin; Izoptin; Isoptine; Isoptin; Finoptin; Falicard; Dexverapamil; Cordilox; CalanDrugs* : COVERA-HS; VERAPAMIL HYDROCHLORIDE; VERAPAMIL HCL; VERELAN; ISOPTIN; VERELAN PM; CALAN; CALAN SR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-hydroxy-2,2,6,6-tetramethyl-1,2,3,6-tetrahydro-pyridine-4-carboxylic acid-(2-(3,4-dimethoxyphenyl)-5-(2-(3,4-dimethoxyphenyl)ethyl)methylamino)-2-isopropyl-pentylamide  0   Verapamil/*analogs & derivatives. Bioorg Med Chem. 2010 Apr 15;18(8):2954-63
HO-4038  0   Verapamil/*analogs & derivatives. Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H140-51
1-hydroxy-2,2,5,5-tetramethyl-2,5-diydro-1H-pyrrole-3-carboxylic acid (2-(3,4-dimethoxyphenyl)-5-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)-2-isopropylpentyl)amide  0   *Pyrroles Verapamil/*analogs & derivatives. J Pharmacol Exp Ther 2007 Oct;323(1):119-27
CL 347099  0   Verapamil/*analogs & derivatives. Parasitol Res 1999 Dec;85(12):1007-11
alpha-(3-((2-(4-hydroxy-3,5-diiodophenyl)ethyl)methylamino)propyl) -3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile  0   Verapamil/*analogs & derivatives Apoptosis. Cancer Res 2004 Jul 15;64(14):4950-6
2-(3,4-dimethoxyphenyl)-8-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile  0   *Nitriles Verapamil/*analogs & derivatives. Drug Metab Dispos. 2003 Jul;31(7):888-91
2-(3,4-dimethoxyphenyl)-5-methylamino-2-isopropylvaleronitrile  0   *Nitriles Verapamil/*analogs & derivatives. Drug Metab Dispos. 2003 Jul;31(7):888-91
2-(3,4-dimethoxyphenyl)-5-amino-2-isopropylvaleronitrile  34245-14-2 3,4-dimethoxy-alpha-(3-(methylamino)propyl)-alpha-(1-methylethyl)benzeneacetonitrile  *Nitriles Verapamil/*analogs & derivatives. Drug Metab Dispos. 2003 Jul;31(7):888-91
KR30031  0   Verapamil/*analogs & derivatives. Pharm Res 2003 Jan;20(1):24-30
noremopamil  0   Verapamil/*analogs & derivatives. J Org Chem 2002 Aug 23;67(17):6228-31
2-(2-isopropyl)-5-hydroxy-2-phenylpentanenitrile  0   Verapamil/*analogs & derivatives. J Org Chem 2002 Aug 23;67(17):6228-31
EDP 96  0   Verapamil/*analogs & derivatives. Chem Biol Interact 2001 Jul 31;137(1):1-13
PB-3 flush solution  0   *Adenosine *Allopurinol *Mannitol *Verapamil Organ Preservation Solutions. Transpl Int 1994;7 Suppl 1:S469-71
D 703  0   Verapamil/*analogs & derivatives. J Pharmacol Exp Ther 2000 May;293(2):376-82
KR 30035  0   *Tetrahydronaphthalenes Verapamil/*analogs & derivatives. Anticancer Drugs 1998 Feb;9(2):157-65
KR 30032  0   *Indenes Verapamil/*analogs & derivatives. Anticancer Drugs 1998 Feb;9(2):157-65
Ro 44-5911  0   Verapamil/*analogs & derivatives. Anticaner Drugs 1996 Jun;7(4):430-6
CVAD-V protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Doxorubicin Verapamil Vincristine. Leuk Lymphoma 1995 Nov;19(5-6):511-4
Ro 44-5912  0   Verapamil/*analogs & derivatives. Anticancer Res 1995 May-Jun;15(3):911-6
nexopamil  136033-49-3   Verapamil/*analogs & derivatives. J Cardiovasc Pharmacol 1993 Nov;22(5):687-94
Osaka University cocktail  0   Epoprostenol/analogs & derivatives Verapamil Organ Preservation Solutions. Transplant Proc 1993 Dec;25(6):3093-4
Bodipy-verapamil  137759-83-2   Verapamil/*analogs & derivatives. Mol Pharmacol 1991;40(4):490
(N-benzoyl)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-N-4-azidobenzoylpentylamine  117638-38-7   Verapamil/*analogs & derivatives. Cancer Res 1989;49(18):5002
D 595  16740-29-7   Verapamil/*analogs & derivatives. Biochem Pharmacol 1989;38(14):2233
devapamil  92302-55-1   Verapamil/*analogs & derivatives.
Pharma Action Calcium Channel Blockers
Naunyn Schmiedeberg Arch Pharmacol 1988;337(2):213
emopamil  78370-13-5   Verapamil/*analogs & derivatives.
Pharma Action Calcium Channel Blockers
Transplantation 1987;43(6):928
LU 49888  109293-21-2   *Azides Verapamil/*analogs & derivatives Tritium. FEBS Lett 1987;212(2):247
5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentyl isothiocyanate  102852-53-9   Verapamil/*analogs & derivatives. J Med Chem 1986;29(9):1789
phenoptin  0   *Verapamil. Sov Med 1985;(6):9
carboxyverapamil  0   Verapamil/*analogs & derivatives. Eur J Pharmacol 1984;104(3-4):267
4-desmethoxyverapamil  93468-87-2 Benzeneacetonitrile, 3,4-dimethoxy-alpha-(3-((2-(3-methoxyphenyl)ethyl)methylamino)propyl)-alpha-(1-methylethyl)-, (-)  Verapamil/*analogs & derivatives. FEBS Lett 1984;176(2):371
quinidine, verapamil drug combination  0   *Quinidine *Verapamil Drug Combinations. ZFA (Stuttgart) 1982;58(8):488
stenoptin  79057-87-7 D-Glucitol, 1,4-3,6-dianhydro-, dinitrate, mixt. with alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile monohydrochloride  *Isosorbide Dinitrate *Verapamil Drug Combinations. ZFA (Stuttgart) 55(25):1399;1979
alpha-(3-aminopropyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile  27487-66-7   Verapamil/*analogs & derivatives. Cardiovasc Res 12(4):247;1978
norverapamil  67018-85-3 alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile  Verapamil/*analogs & derivatives.
Pharma Action Calcium Channel Blockers
Cardiovasc Res 12(4):247;1978; J Chromatogr 1980;181(3-4):484

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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