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Vidarabine

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Definition: A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.  an antiviral & antimetabolite   
Pharmacological Action Antimetabolites; Antiviral Agents 		Other names Arabinosyladenine; Arabinofuranosyladenine; Ara-A; Adenine Arabinoside; beta Ara A; alpha D Arabinofuranosyladenine; alpha Ara A; ViraA; Vira A; Arabinoside, Adenine; A, beta-Ara; A, alpha-Ara; A, Ara; 9 beta D Arabinofuranosyladenine; 9 beta Arabinofuranosyladenine; beta-Ara A; alpha-D-Arabinofuranosyladenine; alpha-Ara A; Vira-A; Parke Davis Brand of VidarabineDrugs* : VIRA-A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
R-FCM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Mitoxantrone Vidarabine/analogs & derivatives Antibodies, Monoclonal, Murine-Derived. Leukemia 2007 Mar;21(3):524-8
9-(2,3,5-tri-O-benzylarabinofuranosyl)-2-fluoroadenine  0   Vidarabine/*analogs & derivatives. Nucleosides Nucleotides Nucleic Acids 2006;25(7):735-45
MIFAP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cytarabine Mitoxantrone Vidarabine/analogs & derivatives. J Cancer Res Clin Oncol 2001;127(6):387-95
FBM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Melphalan Vidarabine/analogs & derivatives. Bone Marrow Transplant. 2000 Aug;26(3):243-50
FLU-ID regimen  0   *Antineoplastic Combined Chemotherapy Protocols Vidarabine/analogs & derivatives Idarubicin. Haematologica 1999 Nov;84(11):1002-6
FLAM regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Mitoxantrone Vidarabine/analogs & derivatives. Cancer 1999 Dec 1;86(11):2246-51
Ida-FLAG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Vidarabine/*analogs & derivatives Idarubicin Granulocyte Colony-Stimulating Factor. Ann Hematol 1999 Sep;78(9):418-25
FLIDA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Prednisone Vidarabine/analogs & derivatives Idarubicin. Henatol Oncol 1997 Feb;15(1):27-31
9-arabinofuranosyl-6-azidopurine  53821-43-5   Vidarabine/*analogs & derivatives. J Med Chem 1996 Dec 20;39(26):5202-7
6-azido-2',3'-dideoxy-2'-fluoro-beta-arabinofuranosylpurine  0   *Azides Vidarabine/*analogs & derivatives. J Med Chem 1996 Nov 8;39(23):4676-81
N(6)-methyl-2',3'-dideoxy-2'-fluoro-beta-arabinofuranosyladenine  126502-17-8   Vidarabine/*analogs & derivatives. J Med Chem 1996 Nov 8;39(23):4676-81
FLANG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Mitoxantrone Vidarabine/analogs & derivatives Granulocyte Colony-Stimulating Factor. Leuk Lymphoma 1996 Jun;22(1-2):173-6
FMP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Prednisone Vidarabine/analogs & derivatives. Eur J Haematol 1995 Oct;55(4):262-6
FLAG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Vidarabine/analogs & derivatives Granulocyte Colony-Stimulating Factor. Br J Haematol 1994 Feb;86(2):394-6
FND protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Mitoxantrone Vidarabine/analogs & derivatives. J Clin Oncol 1994 Mar;12(3):575-9
6-methylaminopurine arabinoside  60209-41-8   Vidarabine/*analogs & derivatives. Antimicrob Agents Chemother 1992 Feb;36(2):353-60
6-dimethylaminopurine arabinoside  0   Vidarabine/*analogs & derivatives. Antimicrob Agents Chemother 1992;36(2):353-60
2',3'-dideoxy-2'-fluoroarabinofuranosyladenine  110143-09-4   Vidarabine/*analogs & derivatives. Biochem Pharmacol 1987;36(17):2719
cyclaradine-5'-ethoxypropionate  103353-83-9   Vidarabine/*analogs & derivatives. Antimicrob Agents Chemother 1987;31(7):998
9-(5'-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-beta-arabinosyl)adenine  78000-58-5   *Organophosphorus Compounds Vidarabine/*analogs & derivatives. J Med Chem 1985;28(9):1358
9-(5'-(2-oxo-1,3,2-oxazaphosphorinan-2-yl)-beta-arabinosyl)adenine  96790-49-7   *Organophosphorus Compounds Vidarabine/*analogs & derivatives. J Med Chem 1985;28(9):1358
cyclaradine-5'-methoxyacetate  81566-77-0 Acetic acid, methoxy-, (4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl ester, (1alpha,2beta,3alpha,4alpha)-(+-)  Vidarabine/*analogs & derivatives. Antimicrob Agents Chemother 1983;24(4):538
vidarabine 2',3'-diacetate  65174-96-1   Vidarabine/*analogs & derivatives. Antiviral Res 1982;2(1/2):27
vidarabine 2',3',5'-triacetate  15830-52-1   Vidarabine/*analogs & derivatives. Antiviral Res 1982;2(1/2):27
ara-3-deazaadenine  0   Vidarabine/*analogs & derivatives. J Med Chem 1982;25(1):96
ara-A-homocysteine  55267-52-2 9H-Purin-6-amine, 9-(5-S-(3-amino-3-carboxypropyl)-5-thio-beta-D-arabinofuranosyl)-, (S)  Vidarabine/*analogs & derivatives. J Pharmacol Exp Ther 1981;218(3):758
9 beta-D-arabinofuranosyladenine 5'-diphosphate-5'-1,2-dipalmitin  78679-19-3 9H-Purin-6-amine, 9-(5-O-(1,3-dihydroxy-6-((1-oxohexadecyl)oxy)-9-oxo-2,4,8-trioxa-1,3-diphosphatetracos-1-yl)-beta-D-arabinofuranosyl)-, P,P'-dioxide, (R)  Vidarabine/*analogs & derivatives. Cancer Res 1981;41(7):2707
9-alpha-arabinofuranosyl-8-azaadenine  35827-89-5   Vidarabine/*analogs & derivatives. Biochem Pharmacol 1981;30(16):2325
2-amino-2-deoxy-beta-arabinofuranosyladenine  69427-80-1   Vidarabine/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1979;27(3):821
vidarabine 5'-valerate  65926-31-0 9H-Purin-6-amine, 9-(5-O-(1-oxopentyl)-beta-D-arabinofuranosyl)  Vidarabine/*analogs & derivatives. J Pharm Sci 1980;69(7):772
fludarabine  21679-14-1 9H-purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro  Vidarabine/*analogs & derivatives DNA (Cytosine-5-)-Methyltransferase/antagonists & inhibitors Enzyme Inhibitors Myeloablative Agonists.
Pharma Action Antineoplastic Agents 		Cancer Res 1980;40(5):1405
9 beta-D-arabinofuranosyl-8-n-butylaminoadenine  0   Vidarabine/*analogs & derivatives. Biochim Biophys Acta 1979;565(2):379
arazide  69370-82-7 9H-Purin-6-amine, 9-(2-azido-2-deoxy-beta-D-arabinofuranosyl)  Vidarabine/*analogs & derivatives. Biochem Pharmacol 28(13):2105;1979
arabinosyl-N(6)-hydroxyadenine-9-beta-D-arabinofuranosyl-6-hydroxylaminopurine  24822-51-3 6H-Purin-6-one, 9-beta-D-arabinofuranosyl-1,9-dihydro-, oxime  Vidarabine/*analogs & derivatives. Ann NY Acad Sci 284:351;1977; Mol Pharm 14(1):199;1978
carbocyclic arabinosyladenine  13089-44-6   Vidarabine/*analogs & derivatives. J Med Chem 20(4):612;1977
ara-DAP  34079-68-0 9H-Purine-2,6-diamine, 9-beta-D-arabinofuranosyl  Vidarabine/*analogs & derivatives. Ann N Y Acad Sci 255:468;1975; J Antimicrob Chemotherap 3 Suppl A:73;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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