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Xanthine Oxidase

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Definition: An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria.  /defic: consider also XANTHINES /urine (IM) + PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS (IM)    Other names Hypoxanthine Oxidase; Purine Xanthine Oxidase; Oxidase, Purine-Xanthine; Oxidase, Hypoxanthine-Xanthine; Oxidase, Hypoxanthine; Hypoxanthine Xanthine Oxidase; Dehydrogenase, Hypoxanthine; Purine-Xanthine Oxidase; Hypoxanthine-Xanthine Oxidase; Hypoxanthine Dehydrogenase; Oxidase, Xanthine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tetrahydroamentoflavone  0   *Biflavonoids Xanthine Oxidase/antagonists & inhibitors. J Ethnopharmacol 2011 Feb 16;133(3):1117-20
3,5,2',4'-tetrahydroxychalcone  0   *Chalcones Xanthine Oxidase/antagonists & inhibitors. Chem Biol Interact. 2011 Feb 1;189(3):161-6
3-amino-6-(4-chloro-2-hydroxy-5-methylphenyl)-1H-pyrazolo(3,4-d)thiazolo(3,2-a)pyrimidin-4-one  0   *Pyrimidinones *Thiazoles Xanthine Oxidase/antagonists & inhibitors. J Enzyme Inhib Med Chem 2010 Oct;25(5):615-21
3-amino-6-(2-hydroxyphenyl)-1H-pyrazolo(3,4-d)thiazolo(3,2-a)pyrimidin-4-one  0   *Pyrimidinones *Thiazoles Xanthine Oxidase/antagonists & inhibitors. J Enzyme Inhib Med Chem 2010 Oct;25(5):615-21
4-amino-6-hydroxypyrazolo(3,4-d)pyrimidine  0   Oxypurinol/*analogs & derivatives Xanthine Oxidase/antagonists & inhibitors. Exp Biol Med (Maywood). 2010 Apr 1;235(4):487-96
4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone  0   *Glucosides *Kaempferols Xanthine Oxidase/antagonists & inhibitors. Yao Xue Xue Bao. 2009 Apr;44(4):390-4
kaempherol 3-O-beta-rhamnopyranosyl (1-6)-beta-D-glucopyranoside  0   *Glucosides *Kaempferols Xanthine Oxidase/antagonists & inhibitors. Yao Xue Xue Bao. 2009 Apr;44(4):390-4
loniceraflavone  0   *Flavonoids Xanthine Oxidase/antagonists & inhibitors. Planta Med 2009 Mar;75(4):302-6
renierol  0   *Isoquinolines *Quinones Xanthine Oxidase/antagonists & inhibitors. J Enzyme Inhib Med Chem 2008 Jun;23(3):406-10
aurantiamide benzoate  0   *Dipeptides Xanthine Oxidase/antagonists & inhibitors. Yakugaku Zasshi 2007 Feb;127(2):389-95
4,9-dichlorodibenzodioxin  0   *Dioxins Xanthine Oxidase/analogs & derivatives. Biochemistry (Mosc) 2000 Aug;65(8):972-5
5-hydroxy-3,4,7-triphenyl-2,6-benzofurandione  0   *Benzofurans Xanthine Oxidase/antagonists & inhibitors. J Antibiot (Tokyo) 1998 May;51(5):528-30
hydroxyakalone  0   *Pyrazoles *Pyrimidines Xanthine Oxidase/antagonists & inhibitors. Jpn J antibiot 1997 Nov;50(11):916-8
tetradecadiene-8,10-diyne-1,3-diol diacetate  0   *Fatty Alcohols *Diynes Xanthine Oxidase/antagonists & inhibitors. Biol Pharm Bull 1994 Oct;17(10):1364-8
febuxostat  144060-53-7 5-Thiazolecarboxylic acid, 2-(3-cyano-4-(2-methylpropoxy)phenyl)-4-methyl  *Thiazoles Xanthine Oxidase/antagonists & inhibitors Hyperuricemia.
Pharma Action Gout Suppressants 		Eur J Pharmacol 1993 Sep 14;241(2-3):183-8ULORIC
BOF 4272  142181-44-0   *Triazines Xanthine Dehydrogenase/antagonists & inhibitors Xanthine Oxidase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Adv Exp Med Biol 1991;309A:135-8
6-(bromomethyl)-9H-purine  14225-98-0   *Purines Xanthine Oxidase/antagonists & inhibitors. J Biol Chem 1990;265(23):13540
2,3,4,5,6-pentagalloylglucose  50678-27-8 D-Glucose, 2,3,4,5,6-pentakis(3,4,5-trihydroxybenzoate)  Gallic Acid/*analogs & derivatives Glucose/*analogs & derivatives alpha-Glucosidases/antagonists & inhibitors Xanthine Oxidase/antagonists & inhibitors. Biochem J 1988;255(3):937
1'-acetoxychavicol acetate  52946-22-2 Benzenemethanol, 4-(acetyloxy)-alpha-ethenyl-, acetate, (S)  *Benzyl Alcohols Plant Extracts Xanthine Oxidase/antagonists & inhibitors. Planta Med 1985;(6):507
8-bromoxanthine  10357-68-3   *Xanthines Xanthine Oxidase/antagonists & inhibitors. J Biol Chem 1984;259(3):1570
purpurogallin  569-77-7 2,3,4,6-tetrahydroxy-5H-benzocyclohepten-5-one  *Benzocycloheptenes Xanthine Oxidase/antagonists & inhibitors.
Pharma Action Anti-Infective Agents ; Antioxidants ; Enzyme Inhibitors ; Food Preservatives ; Serine Proteinase Inhibitors 		Mutat Res 68(3):201;1979
arsenite  15502-74-6   *Arsenites Xanthine Oxidase/antagonists & inhibitors.
Pharma Action Teratogens 		Acta Biochim Pol 24:253;1977; Am J Physiol 237(2):F93;1979; Arch Microbiol 113(3):265;1977; Biochim Biophys Acta 1979;574(3):487; Cancer Res 39(6):2195;1979; Experientia 35(2):221;1979; Exptl Cell Res 109:277;1977; J Agric Food Chem 1979;27(6):1229
3-(4-pyrimidinyl)-5-(4-pyridyl)-1,2,4-triazole  36646-37-4   *Triazoles Xanthine Oxidase/antagonists & inhibitors. J Pharmacol Exp Ther 190(3):563;1974
8,8'-dioxo-6,6'-azopurine  52583-98-9   *Purines Curare/antagonists & inhibitors Xanthine Oxidase/antagonists & inhibitors. J Med Chem 17(6):639;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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