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1-Naphthylamine

More information in Books or onNLM PubMed
Definition: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.  a carcinogen; D25-26 qualif   
Pharmacological Action Carcinogens
Examples Sertraline 		Other names alpha-Naphthylamine; 1-Aminonaphthalene; alpha Naphthylamine; 8 Aminonaphthalene; 1 Naphthylamine; 1 Aminonaphthalene; Naphthalidine; 8-Aminonaphthalene
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N,N-bis((E)-2-thienylmethylidene)-1,8-naphthalenediamine  0   1-Naphthylamine/*analogs & derivatives. J Photochem Photobiol B. 2011 Sep 2;104(3):449-56
N,N-dimethylaminonapthyl-(acrylo)-nitrile  0   *Nitriles 1-Naphthylamine/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc 2011 May;78(5):1525-34
3-(4,5-bis(dimethylamino)napthalen-1-yl)furan-2,5-dione  0   *Maleic Anhydrides 1-Naphthylamine/*analogs & derivatives. J Org Chem. 2010 Oct 15;75(20):6977-9
N,N-dimethylamino naphthyl acrylic acid ethyl ester  0   *Acrylates 1-Naphthylamine/*analogs & derivatives. Photochem Photobiol Sci 2009 Jan;8(1):101-10
poly(1-naphthylamine)  0   *Polymers 1-Naphthylamine/*analogs & derivatives. J Biomater Sci Polym Ed 2008;19(11):1535-46
1-(2-((1-amino-1,2,3,4-tetrahydronaphthalen-2-yl)carbonylamino)-3-(4-chlorophenyl)propanoyl)-N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide  0   *Piperidines 1-Naphthylamine/*analogs & derivatives Receptor, Melanocortin, Type 4/agonists. Xenobiotica 2008 Nov;38(11):1437-51
1,5-bis(4,6-dichloro-1,3,5-triazinylamino)naphthalene  0   *Triazines 1-Naphthylamine/*analogs & derivatives. Luminescence 2007 Nov-Dec;22(6):581-7
(R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine  0   1-Naphthylamine/*analogs & derivatives. Mol Pharmacol 2006 Nov;70(5):1771-82
N-allyl-4-(4'-methyl-piperazinyl)-1,8-naphthalimide  0   *Piperazines 1-Naphthylamine/*analogs & derivatives. Analyst 2005 Nov;130(11):1551-6
8-(3-(4-cyclohexylpiperazin-1-yl)propyl)-4-methoxy-5,6,7,8-tetrahydronaphthalen-1-ylamine  0   1-Naphthylamine/*analogs & derivatives Ligands. J Med Chem 2006 Jul 13;49(14):4153-8
N-(o-boronic acid)benzyl-1-naphthylamine  0   *Boronic Acids 1-Naphthylamine/*analogs & derivatives. Luminescence 2005 Jul-Oct;20(4-5):331-3
N-phenyl-2-naphthalenamine  0   1-Naphthylamine/*analogs & derivatives. Zhongguo Zhong Yao Za Zhi 2005 Mar;30(5):347-50
N(6)-(1-naphthyl)adenosine diphosphate  0   Adenosine Diphosphate/*analogs & derivatives 1-Naphthylamine/*analogs & derivatives. J Med Chem 2005 Aug 25;48(17):5408-11
4-(2-chloroethyl)-3-(5,6,7-trimethoxyindolyl-2-carboxamido)-1-naphthylamine  0   1-Naphthylamine/*analogs & derivatives. J Med Chem 2005 Jun 2;48(11):3903-18
4-(dimethylamino)naphthalene-1-boronic acid  0   *Boronic Acids 1-Naphthylamine/*analogs & derivatives. Org Lett 2003 Nov 27;5(24):4599-602
1-naphthylphenylamine  0   *Aniline Compounds 1-Naphthylamine/*analogs & derivatives. Appl Environ Microbiol 2002 Sep;68(9):4502-8
1,8-bis(dimethylamino)naphthalene  0   1-Naphthylamine/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc 2000 Aug;56A(9):1801-12
8-dimethylamino-1-dimethylammonionaphthalene  0   1-Naphthylamine/*analogs & derivatives. Acta Crystallogr C 1999 Sep 15;55( Pt 9):1499-503
norsertraline  0   1-Naphthylamine/*analogs & derivatives. Biomed Chromatogr 1996 Nov-Dec;10(6):351-4
3-bromo-4-(hexylamino)-N-hexyl-1,8-naphthalimide  0   *Naphthalimides 1-Naphthylamine/*analogs & derivatives. Antiviral Res 1994 Oct;25(2):133-46
4-amino-1,8-naphthalimide  1742-95-6   *Quinolones *Naphthalimides 1-Naphthylamine/*analogs & derivatives Poly(ADP-ribose) Polymerases. Biochem Biophys Res Commun 1994 Mar 30;199(3):1270-7
1,14-bis-(N-hexyl-3'-bromo-1,8'-naphthalimide-4'-yl)-1,4,11,14-tetraazatetradecane-5,10-dione  149849-59-2   *Naphthalimides 1-Naphthylamine/*analogs & derivatives HIV-1. AIDS Res Hum Retroviruses 1993 Sep;9(9):891-6
FD & C Yellow 11  2478-20-8   1-Naphthylamine/*analogs & derivatives Cosmetics. Contact Dermatitis 1975;1(2):121
CGS 21595  121412-39-3 1,2-Naphthalenediol, 4-(cyclohexylmethylamino)-, diacetate (ester)  1-Naphthylamine/*analogs & derivatives. Vet Pathol 1992 Mar;29(2):145-51
1-benzoyl-2-(naphth-1-ylamino)ethene  69807-62-1   1-Naphthylamine/*analogs & derivatives. Agents Actions 1991;32(1-1):112
N-(guanin-8-yl)-1-naphthylamine  80156-61-2   1-Naphthylamine/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1981;29(9):2730
1-N,N-bis(beta-bromoethyl)amino-3-methylnaphthalene  70974-82-2   1-Naphthylamine/*analogs & derivatives. Br J Cancer 1982;45(6):830
N,N-dimethyl-1-naphthylamine  86-56-6   1-Naphthylamine/*analogs & derivatives. Lab Delo 1982;(3):27
1,5-naphthalenediamine  2243-62-1   1-Naphthylamine/*analogs & derivatives. IARC Monogr Eval Carcinog Risk Chem Human 1982;27:127
1,4-naphthylenediamine  2243-61-0 1,4-Naphthalenediamine  1-Naphthylamine/*analogs & derivatives. Rev Inst Med Trop Sao Paulo 20(4):219;1978
N-hydroxy-1-naphthylamine  607-30-7 N-hydroxy-1-naphthalenamine  1-Naphthylamine/*analogs & derivatives. Cancer Res 38(11):3628;1978
N-heptyl-1,2,3,4-tetrahydro-6-methoxy-1-naphthylamine methanesulfonate  67510-73-0 1-Naphthalenamine, N-heptyl-1,2,3,4-tetrahydro-6-methoxy-, methanesulfonate  1-Naphthylamine/*analogs & derivatives. J Pharm Sci 67(6):882;1978
N-phenyl-1-naphthylamine  90-30-2   1-Naphthylamine/*analogs & derivatives.
Pharma Action Carcinogens ; Fluorescent Dyes 		Biochim Biophys Acta 449:401;1976; Biochim Biophys Acta 497:707;1977; Biochim Biophys Acta 512(1):72;1978; Blood 46(5):751;1975; FEBS Lett 77(2):187;1977; Immunofluorescence Relat Stain Tech W3 IN181T 6th 1978 p.58; J Chromatogr 120(1):211;1976; Mol Aspects Membrane Transport 22:567;1978
N-methyl-N-1-naphthyl-2-fluoroacetamide  5903-13-9   1-Naphthylamine/*analogs & derivatives. Exp Anim (Tokyo) 21(2):89;1972
lometraline  39951-65-0 1-naphthalenamine, 8-chloro-1,2,3,4-tetrahydro-5-methoxy-N,N-dimethyl  1-Naphthylamine/*analogs & derivatives. Curr Ther Res 14(2):65;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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