encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

2-Acetylaminofluorene

More information in Books or onNLM PubMed
Definition: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.  D25-26 qualif   
Pharmacological Action Carcinogens
Examples Acetoxyacetylaminofluorene; Hydroxyacetylaminofluorene 		Other names Fluoren-2-ylacetamide; 2-Acetamidofluorene; N 2 Fluorenylacetamide; Fluoren 2 ylacetamide; 2 Fluorenylacetamide; 2 Acetylaminofluorene; 2 Acetamidofluorene; N-2-Fluorenylacetamide; Acetylaminofluorene; 2-AAF; 2-Fluorenylacetamide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-acetyl-2-aminofluorene  0   2-Acetylaminofluorene/*analogs & derivatives. J Appl Toxicol 1999 Jan-Feb;19(1):1-6
iodo-N-2-(4-hydroxyphenylacetamido)fluorene  0   2-Acetylaminofluorene/*analogs & derivatives Iodine Radioisotopes. J Immunol Methods 1998 Apr 22;109(1):103-12
2,7-diacetylaminofluorene  304-28-9   2-Acetylaminofluorene/*analogs & derivatives.
3-acetylaminofluorene  6292-55-3 Acetamide, N-9H-fluoren-3-yl  *2-Acetylaminofluorene Isomerism.
2-acetylaminofluoren-9-one  3096-50-2   2-Acetylaminofluorene/*analogs & derivatives. Xenobiotica 1993 Mar;23(3):241-57
2-(bromoacetylamino)fluorene  41098-69-5   2-Acetylaminofluorene/*analogs & derivatives. Mol Pharmacol 1992 Jul;42(1):82-93
N-nitroso-N(2)-fluorenylacetamide  114119-92-5   *Nitroso Compounds 2-Acetylaminofluorene/*analogs & derivatives. Mutat Res 1988;201(1):117
2-acetylaminofluorene-N-sulfate  16808-85-8   2-Acetylaminofluorene/*analogs & derivatives. Carcinogenesis 1985;6(11):1635
N-acetoxy-7-ethyl-N-2-acetylaminofluorene  80382-39-4 Acetamide, N-(acetyloxy)-N-(7-ethyl-9H-fluoren-2-yl)  2-Acetylaminofluorene/*analogs & derivatives. Carcinogenesis 1981;2(10):1019
N-myristoyloxy-N-acetyl-2-amino-7-iodofluorene  79127-47-2 Acetamide, N-(7-iodo-9H-fluoren-2-yl)-N-((1-oxotetradecyl)oxy)  2-Acetylaminofluorene/*analogs & derivatives. Carcinogenesis 1981;2(7):655
4-acetylaminofluorene  28322-02-3   2-Acetylaminofluorene/*analogs & derivatives.
Pharma Action Carcinogens 		Cancer Lett 1980;10(2):95
N-myristoyloxy-N-acetyl-2-aminofluorene  63224-44-2 Acetamide, N-9H-fluoren-2-yl-N-((1-oxotetradecyl)oxy)  2-Acetylaminofluorene/*analogs & derivatives. Mutat Res 1980;76(1):1
2,7-bis((pyrrolidino)acetamido)fluoren-9-one  64953-57-7 N,N'-(9-oxo-9H-fluorene-2,7-diyl)bis-1-pyrrolidineacetamide  2-Acetylaminofluorene/*analogs & derivatives. Acta Biol Med Ger 38(5-6):733;1979; Acta Biol Med Ger 38(5-6):745;1979
2,7-bis((morpholino)acetamido)fluoren-9-one  0   2-Acetylaminofluorene/*analogs & derivatives. Acta Biol Med Ger 38(5-6):733;1979
2,7-bis((dipropylamino)acetamido)fluoren-9-one  65091-40-9 N,N'-(9-oxo-9H-fluorene-2,7-diyl)bis(2-(dipropylamino))acetamide  2-Acetylaminofluorene/*analogs & derivatives. Acta Biol Med Ger 38(5-6):733;1979; Acta Biol Med Ger 38(5-6):745;1979
2,7-bis((diethylamino)acetamido)fluoren-9-one  59635-72-2 N,N'-(9-oxo-3H-fluorene-2,7-diyl)bis(2-(diethylamino))acetamide  2-Acetylaminofluorene/*analogs & derivatives. Acta Biol Med Ger 38(5-6):733;1979
7-iodo-N-2-acetylaminofluorene  43146-78-7   2-Acetylaminofluorene/*analogs & derivatives. Mutat Res 67(1):85;1979
7-fluoro-N-2-acetylaminofluorene  343-89-5   2-Acetylaminofluorene/*analogs & derivatives. Mutat Res 67(1):85;1979
N-(deoxyguanosin-8-yl)acetylaminofluorene  37819-60-6   Deoxyguanosine/*analogs & derivatives 2-Acetylaminofluorene/*analogs & derivatives. Cancer Res 39(4):1377;1979

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy