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beta-Alanine

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Definition: An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.     
Examples Pantothenic Acid 		Other names 3-Aminopropionic Acid; beta Alanine, Monosodium Salt; beta Alanine, Monopotassium Salt; beta Alanine Hydrochloride; beta Alanine; Hydrochloride, beta-Alanine; 3 Aminopropionic Acid; beta-Alanine, Monosodium Salt; beta-Alanine, Monopotassium Salt; beta-Alanine, Calcium Salt (2:1); beta-Alanine Hydrochloride
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AZ 505  0   *Benzoxazines beta-Alanine/*analogs & derivatives Histone-Lysine N-Methyltransferase/antagonists & inhibitors. Structure. 2011 Sep 7;19(9):1262-73.
3-(allyltrisulfanyl)-2-aminopropanoic acid  0   *Sulfhydryl Compounds beta-Alanine/*analogs & derivatives. J Med Food. 2010 Oct;13(5):1247-53
N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine  0   *Benzimidazoles beta-Alanine/*analogs & derivatives. Drug Metab Dispos 2010 Sep;38(9):1567-75
2-((2,6-dichlorophenyl)carbonylamino)-3-((2,4,8-triaza-2-methyl-1-oxo-4-phenylspiro(4.5)dec-8-yl)carbonylamino)propanoic acid  0   *Spiro Compounds beta-Alanine/*analogs & derivatives Integrin alpha4beta1/antagonists & inhibitors. J Pharm Sci 2010 Sep;99(9):3986-4004
methyl 3-((9-(dimethylamino)nonanoyl)(methoxy)amino)propanoate  0   *Hydroxamic Acids beta-Alanine/*analogs & derivatives Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5629-38
methyl 3-((9-(dimethylamino)nonanoyl)(hydroxy)amino)propanoate  0   *Hydroxamic Acids beta-Alanine/*analogs & derivatives Jumonji Domain-Containing Histone Demethylases/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5629-38
XVA 143  0   *Phthalic Acids beta-Alanine/*analogs & derivatives. Antimicrob Agents Chemother 2009 Nov;53(11):4656-66
mycmycin-2  0   *Sulfonamides beta-Alanine/*analogs & derivatives. Bioorg Med Chem Lett 2009 Nov 1;19(21):6038-41
mycmycin-1  0   *Sulfonamides beta-Alanine/*analogs & derivatives. Bioorg Med Chem Lett 2009 Nov 1;19(21):6038-41
3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid  0   beta-Alanine/*analogs & derivatives. J Am Chem Soc. 2009 Sep 16;131(36):12921-3
beta-alanine-arm-ICAT  0   *Heterocyclic Compounds, 2-Ring beta-Alanine/*analogs & derivatives. Bioconjug Chem. 2008 May;19(5):1095-104
2-(2,6-dichloro-4-((3-furan-2-ylacryloylamino)methyl)benzoylamino)-3-((thiazolidine-4-carbonyl)amino)propionic acid  0   *Acrylamides beta-Alanine/*analogs & derivatives Lymphocyte Function-Associated Antigen-1. Xenobiotics 2008 Mar;38(3):340-52
beta-alanylcholesteryl formylhydrazide  0   Cholesterol/*analogs & derivatives beta-Alanine/*analogs & derivatives. Drug Deliv 2008 Feb;15(2):97-105
1-(2-(1-(3-dimethylaminopropionyl)amino-2-methylpropyl)-4-methylphenyl)-4-(2-methyl-3-(4-chlorophenyl)propionyl)piperazine  0   *Piperazines beta-Alanine/*analogs & derivatives Receptor, Melanocortin, Type 4/antagonists & inhibitors. J Med Chem 2007 Nov 1;50(22):5249-52
4-(2-(3,4,5,6-tetrahydropyrimidin-2-ylamino)ethyloxy)benzoyl-2-(N-(3-aminoneopenta-1-carbonyl))aminoethylsulfonylamino-beta-alanine  0   *Sulfonamides beta-Alanine/*analogs & derivatives. Nucl Med Biol 2007 May;34(4):363-70
4-(2-(3,4,5,6-tetrahydropyrimidin-2-ylamino)ethyloxy)benzoyl-2-aminoethylsulfonylamino-beta-alanine  0   *Sulfonamides beta-Alanine/*analogs & derivatives. Nucl Med Biol 2007 May;34(4):363-70
N-(4-((4-(1-cyclohexen-1-yl)((3,5-dichloroanilino)carbonyl)anilino)methyl)benzoyl)-2-hydroxy-beta-alanine  0   *Aniline Compounds beta-Alanine/*analogs & derivatives. J Pharmacol Exp Ther 2007 May;321(2):743-52
AUY 954  0   *Thiophenes beta-Alanine/*analogs & derivatives Receptors, Lysosphingolipid/agonists. Chem Biol 2006 Nov;13(11):1227-34
3-N-oxalyl-L -2,3-diaminopropanoic acid  0   beta-Alanine/*analogs & derivatives. Hum Genet 2006 Jan;118(5):618-25
PC 58538  0   *Phenyl Ethers beta-Alanine/*analogs & derivatives. J Biol Chem 2005 Dec 2;280(48):39709-15
undecyl 3-(dimethylamino)propionate  0   beta-Alanine/*analogs & derivatives. Cell Mol Biol Lett 2004;9(4A):675-83
N-(2-(nicotinoylthio)benzoyl)-beta-alaninamide  0   *Benzamides beta-Alanine/*analogs & derivatives. J Med Chem 2005 Apr 21;48(8):2847-58
N-(2-(5-pyridiniovaleroylthio)benzoyl)-beta-alaninamide  0   *Benzamides beta-Alanine/*analogs & derivatives. J Med Chem 2005 Apr 21;48(8):2847-58
SH 066  0   *Sulfonamides beta-Alanine/*analogs & derivatives Integrin alphaVbeta3/antagonists & inhibitors. Cancer Biother Radiopharm 2003 Aug;18(4):627-41
2-(4-(3-hydroxy-3-(hydroxyphenyl)propyl)-2,6-dichlorophenyl)carbomylamino-3-((thiophen-2-yl)carbonylamino)propanoic acid  0   *Thiophenes beta-Alanine/*analogs & derivatives. Science 2002 Feb 8;295(5557):1086-9
acetoxymethyl N(3)-(4-methoxyfumaroyl)-2,3-diaminopropanoate  0   *Fumarates beta-Alanine/*analogs & derivatives. Microbiology 2001 Jul;147(Pt 7):1955-9
beta-alanine betaine  0   *Quaternary Ammonium Compounds beta-Alanine/*analogs & derivatives. Plant Physiol 2001 Jul;126(3):1241-9
SC 57101B  0   Urea/*analogs & derivatives beta-Alanine/*analogs & derivatives. Thromb Res 2000 Mar 1;97(5):307-15
DMP 745  0   *Isoxazoles beta-Alanine/*analogs & derivatives Receptors, Vitronectin/antagonists & inhibitors. J Med Chem 2000 Jan 13;43(1):27-40
Lys-Nva-FMDP  0   beta-Alanine/*analogs & derivatives. Med Mycol 1998 Jun;36(3):177-80
alaninediacetic acid  0   *beta-Alanine *Acetic Acid. Chemosphere 1997 Feb;34(4):807-15
L 767679  0   *Piperazines beta-Alanine/*analogs & derivatives Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Drug Metab Dispos 1997 Aug;25(8):979-84
cocoamphodiproprionate  86438-79-1   beta-Alanine/*analogs & derivatives. Contact Dermatitis 1996 Oct;35(4):248-9
SC 57461  0   beta-Alanine/*analogs & derivatives. Drug Metab Dispos 1996 Oct;24(10):1124-33
2-methyl-5-nitrophenyl-beta-alanine  0   beta-Alanine/*analogs & derivatives. Biochemistry 1996 Jun 25;35(25):8136-42
GABA-beta-alanine transporter protein, Torpedo marmorata  0   *Fish Proteins *GABA Plasma Membrane Transport Proteins gamma-Aminobutyric Acid beta-Alanine. Eur J Biochem 1995 Dec 15;234(3):794-800
benfuracarb  82560-54-1   *Benzofurans beta-Alanine/*analogs & derivatives. J Toxicol Sci 1995 May;20(2):143-8
L 734217  0   *Piperidines beta-Alanine/*analogs & derivatives. J Med Chem 1995 Aug 18;38(17):3332-41
N(alpha)-(tert-butyloxycarbonyl)-N(beta)-(bromoacetyl)diaminopropionic acid  0   *Carbamates beta-Alanine/*analogs & derivatives. Bioconjug Chem 1995 May-Jun;6(3):269-77
CGP 55461  0   *Benzopyrans beta-Alanine/*analogs & derivatives. J Chromatogr B Biomed Appl 1995 Feb 17;664(2):393-400
CGP 50068  0   *Benzopyrans beta-Alanine/*analogs & derivatives. J Chromatogr B Biomed Appl 1995 Feb 17;664(2):393-400
N-(2-hydroxyethyl)-N-methyl-beta-alanine  0   beta-Alanine/*analogs & derivatives. Exotoxicol Environ Safety 1994 Oct;29(1):113-21
CGS 24128  147861-76-5 beta-Alanine, N-(3-(1,1'-biphenyl)-4-yl-N-(phosphonomethyl)alanyl)  *Phosphonic Acids beta-Alanine/*analogs & derivatives Neprilysin/antagonists & inhibitors. J Cardiovasc Pharmacol 1994 Mar;23(3):358-64
NS 11  150044-75-0   *Guanidines beta-Alanine/*analogs & derivatives. Invest Ophthalmol Vis Sci 1994 Apr;35(5):2585-91
panipenem-betamipron  138240-65-0   Thienamycins beta-Alanine/analogs & derivatives.
Pharma Action Anti-Bacterial Agents 		Jpn J Antibiot 1992 Feb;45(2):143-54
N-(4-cyanophenyl)-N'-(2-carboxyethyl)urea  74390-15-1   *Phenylurea Compounds beta-Alanine/*analogs & derivatives Sweetening Agents. J Med Chem 1992 May 15;35(10):1747-51
N-(4-cyanophenyl)-N'-((sodiosulfo)methyl)urea  134555-22-9   *Phenylurea Compounds beta-Alanine/*analogs & derivatives. J Med Chem 1992 May 15;35(10):1747-51
N(3)-(chloroacetyl)-2,3-diaminopropanoic acid  135630-95-4   beta-Alanine/*analogs & derivatives Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/antagonists & inhibitors. Biochim Biophys Acta 1992 Jan 23;1115(3):225-9
N(3)-(bromoacetyl)-2,3-diaminopropanoic acid  77215-58-8   beta-Alanine/*analogs & derivatives Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/antagonists & inhibitors. Biochim Biophys Acta 1992 Jan 23;1115(3):225-9
2-methylene-beta-alanine  4452-16-8   beta-Alanine/*analogs & derivatives. J Antibiot (Tokyo) 1991;44(7):795
sulfosuccinimidyl-N-(3-(acetylthio)-3-methylbutyryl)-beta-alanine  131068-49-0   *Succinimides beta-Alanine/*analogs & derivatives. Bioconjug Chem 1990;1(6):400
N-(3-mercapto-3-methylbutyryl)-beta-alanine  131068-51-4   *Sulfhydryl Compounds beta-Alanine/*analogs & derivatives. Bioconjug Chem 1990;1(6):400
N(3)-(iodoacetyl)-2,3-diaminopropanoic acid  129365-02-2   beta-Alanine/*analogs & derivatives. J Med Chem 1990;33(10):2755
beta-naphthylalanine  63024-43-1   beta-Alanine/*analogs & derivatives. Biopolymers 1990;29(1):179
insect repellent M 3535  95328-09-9   beta-Alanine/*analogs & derivatives. Geogr Med 1989;(Suppl 2):61
N-chenodeoxycholyl-2-fluoro-beta-alanine  114818-27-8   Chenodeoxycholic Acid/*analogs & derivatives beta-Alanine/*analogs & derivatives. Drug Metab Dispos 1988;16(6):892
N(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid  96920-07-9   *Fumarates beta-Alanine/*analogs & derivatives Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/antagonists & inhibitors. Biochemistry 1988;27(7):2282
technetium TC 99m 2,3-diaminopropionic acid  0   *Organotechnetium Compounds beta-Alanine/*analogs & derivatives. Int J Rad Appl Instrum (B) 1987;14(6):599
N-cholyl-2-fluoro-beta-alanine  110501-27-4 Propanoic acid, 2-fluoro-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)  *Cholic Acids beta-Alanine/*analogs & derivatives. Proc Natl Acad Sci USA 1987;84(15):5439
N,N'-bis(S-benzoylmercaptoacetyl)-2,3-diaminopropionic acid ethyl ester  85916-30-9 Alanine, N-((benzoylthio)acetyl)-3-(((benzoylthio)acetyl)amino)-, (2S-(2alpha,3alpha(S*),5alpha,6beta))  beta-Alanine/*analogs & derivatives. J Nucl Med 1984;25(2):223
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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