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6-Mercaptopurine

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Definition: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.     
Pharmacological Action Antimetabolites; Antimetabolites, Antineoplastic; Immunosuppressive Agents; Nucleic Acid Synthesis Inhibitors 		Other names Wellcome Brand of 6 Mercaptopurine; Puri Nethol; GlaxoSmithKline Brand of 6 Mercaptopurine; Glaxo Wellcome Brand of 6 Mercaptopurine; BW 57323H; BW 57 323H; 6 Thiopurine; 6 Thiohypoxanthine; 6 Mercaptopurine Monohydrate; 6 Mercaptopurine; Wellcome Brand of 6-Mercaptopurine; Purinethol; Purimethol; Puri-Nethol; Mercaptopurine; Mercaptopurina Wellcome; Leupurin; GlaxoSmithKline Brand of 6-Mercaptopurine; Glaxo Wellcome Brand of 6-Mercaptopurine; BW 57-323HDrugs* : PURINETHOL; MERCAPTOPURINE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-carboxymethylthiopurine  0   6-Mercaptopurine/*analogs & derivatives. Chem Biol Drug Des 2008 Jun;71(6):563-7
S6-methylthio-2-aminopurne  0   2-Aminopurine/*analogs & derivatives 6-Mercaptopurine/*analogs & derivatives. Nucleic Acids Res 2007;35(11):3693-704
POG-8498 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Azacitidine Cytarabine Daunorubicin Etoposide Methotrexate Prednisone Thioguanine Vincristine 6-Mercaptopurine. Pediatr Blood Cancer 2007 Mar;48(3):262-7
ALL-BFM-95 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Prednisolone Vincristine 6-Mercaptopurine. Orv Hetil. 2005 Jan 9;146(2):75-80
APO combination  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. J Clin Oncol 2005 Jan 20;23(3):541-7
azathiopurine  0   6-Mercaptopurine/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2003 Nov;59(13):3131-7
ALL-85 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Dexamethasone Etoposide Methotrexate Teniposide Vincristine 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
ALL-82 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Methotrexate Teniposide 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
ALL-80 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
BHAC-AMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Prednisolone 6-Mercaptopurine Aclarubicin. Int J Hematol 2001 Jul;74(1):53-7
tris(6-mercaptopurine)iron(II)  0   *Ferrous Compounds 6-Mercaptopurine/*analogs & derivatives. Acta Crystallogr C 2000 Aug;56( Pt 8):957-9
methyl-6-mercatopurine  0   6-Mercaptopurine/*analogs & derivatives. J Chromatogr B Biomed Sci Appl 1999 Jul 9;730(2):273-4
(9H-purin-6-yl)thiomethyl glutamate  0   6-Mercaptopurine/*analogs & derivatives. Immunopharmacology 1997 Aug;37(1):95-104
AIEOP 8703 protocol  0   Asparaginase *Antineoplastic Combined Chemotherapy Protocols Leucovorin Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1997 Aug 1;90(3):1226-32
POG 8602 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Hydrocortisone Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1990 Jul 1;76(1):117-22
M-DOMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Leuk Lymphoma 1996 Jun;22(1-2):71-6
butocin  22181-94-8   6-Mercaptopurine/*analogs & derivatives.
BFM-86 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1996 Jun 15;87(12):5207-12
HR-1 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Dexamethasone Methotrexate Prednisolone Vincristine 6-Mercaptopurine. Blood 1996 Apr 15;87(8):3143-50
6-methylmercapto-8-hydroxypurine  0   6-Mercaptopurine/*analogs & derivatives. Clin Chem 1996 Mar;42(3):380-6
BMF phase II protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Methotrexate 6-Mercaptopurine. Am J Hematol 1996 Jan;51(1):85-9
6-mercaptopurine 7-N-oxide  0   *Cyclic N-Oxides 6-Mercaptopurine/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1995 Mar;43(3):408-13
TOTAL-XII protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Methotrexate Teniposide 6-Mercaptopurine. Blood 1995 Apr 1;85(7):1897-902
ACOP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Prednisone Vincristine 6-Mercaptopurine. J Clin Oncol 1991 Jul;9(7):1189-95
POG 8493 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cortisone/analogs & derivatives Cyclophosphamide Cytarabine Methotrexate Prednisone Vincristine 6-Mercaptopurine. Acta Haematol Pol 1993;24(2):131-8
BHAC-DMPV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Daunorubicin Prednisolone Vincristine 6-Mercaptopurine. Leuk Lymphoma 1993 Jan;9(1-2):43-8
T-8801 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparagine Cytarabine Etoposide Methotrexate Vincristine 6-Mercaptopurine. Am J Pediatr Hematol Oncol 1993 Feb;15(1):99-104
AIEOP protocol 8202  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Haematologica 1992 Sep-Oct;77(5):427-9
carsatrin  125363-87-3 1-Piperazineethanol, 4-(bis(4-fluorophenyl)methyl)-alpha-((1H-purin-6-ylthio)methyl)  *Piperazines 6-Mercaptopurine/*analogs & derivatives. J Med Chem 1992 Nov 27;35(24):4509-15
non-Hodgkin's lymphoma protocol 8503  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Methotrexate Prednisolone Vincristine 6-Mercaptopurine Trimethoprim-Sulfamethoxazole Combination. Br J Haematol 1992 Oct;82(2):310-6
7+3 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Daunorubicin 6-Mercaptopurine. Ter Arkh 1992;64(8):87-9
AIEOP acute lymphoblastic leukemia protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Haematologica 1992 Jan-Feb;77(1):49-53
GAP-POMP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Am J Pediatr Hematol Oncol 1992 May;14(2):136-9
St Jude's regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Methotrexate Prednisolone Vincristine 6-Mercaptopurine. Hematol Oncol 1991;9(4-5):275
arabinosyl-6-mercaptopurine  892-49-9 9-(beta-D-arabinofuranosyl)-9H-purine-6-thiol  6-Mercaptopurine/*analogs & derivatives.
6-(decyldithio)-1H-purine  78263-73-7   6-Mercaptopurine/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Biochem Pharmacol 1990;39(9):1484
6-(phenyldithio)purine  2958-91-0   6-Mercaptopurine/*analogs & derivatives Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors. Biochem Pharmacol 1990;39(9):1484
6-trimethylsilylthio-9-trimethylsilylpurine  132151-80-5   *Trimethylsilyl Compounds 6-Mercaptopurine/*analogs & derivatives. Arzneimittleforschung 1990;40(1):80
S-(6-purinyl)cysteine  125136-34-7   6-Mercaptopurine/*analogs & derivatives. J Pharmacol Exp Ther 1989;251(2):448
B-DOMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Daunorubicin Prednisolone Vincristine 6-Mercaptopurine. Nippon Ketsueki Gakkai Zasshi 1988;51(8):1641
Cloturin  104789-46-0   *Mustard Compounds 6-Mercaptopurine/*analogs & derivatives. Cesk Farm 1988;37(6):246
protocol 8001  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Hydrocortisone Methotrexate Prednisone Vincristine 6-Mercaptopurine. Am J Pediatr Hematol Oncol 1987;9(4):356
BFHM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Fluorouracil Hydroxyurea 6-Mercaptopurine. Cancer Treat Rep 1986;70(11):1271
9-(n-butyl)-6-mercaptopurine  6165-01-1   6-Mercaptopurine/*analogs & derivatives. Cancer Res 1986;46(1):137
9-ethyl-6-mercaptopurine  5427-20-3   6-Mercaptopurine/*analogs & derivatives. Cancer Res 1986;46(1):137
VEMP protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisolone Vincristine 6-Mercaptopurine. Rinsho Ketsueki 1985;26(7):1140
DOAPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Prednisolone Vincristine 6-Mercaptopurine. J Assoc Physicians India 1985;33(3):203
BH-AC-DMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Daunorubicin Prednisolone 6-Mercaptopurine. Rinsho Ketsueki 1985;26(4):494
POMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Prednisone Vincristine 6-Mercaptopurine. J Pediatr 1985;106(5):723
ACMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Prednisolone 6-Mercaptopurine. Rinsho Ketsueki 1985;26(1):36
A-VBM-FH6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Fluorouracil Hydroxyurea Methotrexate Vincristine 6-Mercaptopurine. Eur J Surg Oncol 1985;11(1):37
BH-AC-AMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine/analogs & derivatives Prednisolone 6-Mercaptopurine Aclarubicin. Rinsho Ketsueki 1984;25(11):1766
MOPA-6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Mechlorethamine Prednisolone Vincristine 6-Mercaptopurine. Hematol Oncol 1984;2(2):151
DCMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Daunorubicin Prednisolone 6-Mercaptopurine. Rinsho Ketsueki 1982;(23)11:1706
DC(M)VP protocol  0   Prednisolone *Antineoplastic Combined Chemotherapy Protocols Daunorubicin Vincristine 6-Mercaptopurine. Rinsho Ketsueki 1982;23(11):1706
bismuth-6-mercaptopurine  66626-12-8 Bismuth, tris(1,9-dihydro-6H-purine-6-thionato-N7,S6)  *Organometallic Compounds 6-Mercaptopurine/*analogs & derivatives Bismuth. Res Comm Chem Pathol Pharmacol 1983;39(1):99
CCG-141 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Methotrexate Prednisone Vincristine 6-Mercaptopurine. Cancer 1983;51(6):1041
6-mercapto-9-(tetrahydro-2-furyl)purine  0 9-(tetrahydro-2-furyl)-6-purinethiol  6-Mercaptopurine/*analogs & derivatives. Biochem Pharmacol 28(7):1057;1979
6-(2,4-dinitrophenyl)mercaptopurine  0   6-Mercaptopurine/*analogs & derivatives. Acta Biol Med Germ 37(4):645;1978
palladium-6-mercaptopurine  20224-80-0 Palladium, bis(1,7-dihydro-6H-purine-6-thionato-N7,S6)  *Organometallic Compounds 6-Mercaptopurine/*analogs & derivatives Palladium. Br J Cancer 38(2):325;1978
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