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Sodium Channels

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Definition: Cell membrane glycoproteins selective for sodium ions. Fast sodium current is associated with the action potential in neural membranes.  /biosyn /drug eff /physiol /rad eff /ultrastruct permitted; DF: NA CHANNELS   
See Also Sodium-Potassium-Exchanging ATPase
Examples Epithelial Sodium Channel 		Other names Ion Channels, Sodium; Sodium Ion Channel; Channels, Sodium Ion; Channels, Sodium; Channel, Sodium Ion; Channel, Sodium; Sodium Ion Channels; Sodium Channel; Ion Channel, Sodium
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
FLR-1 protein, C elegans  0   *Sodium Channels *Caenorhabditis elegans Proteins. Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11775-80
SCN3B protein, mouse  0   *Sodium Channels. Oncogene 2004 Oct 14;23(47):7791-8
NALCN protein, human  0   *Sodium Channels. Channels (Autsin) 2009 May-Jun;3(3):161-3
SCN2B protein, mouse  0   *Sodium Channels. Mol Cell Neurosci 2009 Feb;40(2):143-55
Scn1b protein, rat  0   *Sodium Channels. Science 1992 May 8;256(5058):839-42
Ppk1 protein, Drosophila  0   *Sodium Channels *Drosophila Proteins. Curr Biol 2003 Sep 2;13(17):1557-63
Scn1b protein, mouse  0   *Sodium Channels. Genesis 2007 Sep;45(9):547-53
SCN1B protein, zebrafish  0   *Sodium Channels *Zebrafish Proteins. BMC Genomics 2007;8() (dup#93):226
Scn3a protein, mouse  0   *Sodium Channels. Mol Pain 2006;2:33
scn8aa protein, zebrafish  0   *Sodium Channels *Zebrafish Proteins. Development 2006 Oct;133(19):3827-36
Accn3 protein, mouse  0   *Sodium Channels. J Neurosci 2005 Nov 23;25(47):10981-9
Scn8a protein, rat  0   *Sodium Channels. Nat Genet 1995 Aug;10(4):461-5
Ppk25 protein, Drosophila  0   *Sodium Channels *Drosophila Proteins Protein Subunits. Proc Natl Acad Sci U S A 2005 Sep 6;102(36):12831-6
Scn7a protein, mouse  0   *Sodium Channels.
SCN7A protein, human  0   *Sodium Channels.
Scn6a protein, rat  0   *Sodium Channels.
Scn9a protein, rat  0   *Sodium Channels.
Scn9a protein, mouse  0   *Sodium Channels.
Sap1 protein, rat  0   *Sodium Channels *Adaptor Proteins, Vesicular Transport. Mol Cell Neurosci. 2005 Apr;28(4):636-49
Scn4b protein, mouse  0   *Sodium Channels. Neuron. 2005 Jan 20;45(2):233-44
SCN3B protein, human  0   *Sodium Channels Apoptosis. Oncogene 2004 Oct 14;23(47):7791-8
SCN11A protein, human  0   *Sodium Channels.
Scn11a protein, mouse  0   *Sodium Channels.
Scn4a protein, mouse  0   *Sodium Channels.
Scn8a protein, mouse  0   *Nerve Tissue Proteins *Sodium Channels.
apx-1 protein, C elegans  0   *Sodium Channels *Caenorhabditis elegans Proteins Signal Transduction.
SCN9A protein, human  0   *Sodium Channels. EMBO J 1995 Mar 15;14(6):1084-90
Scn3a protein, rat  0   *Nerve Tissue Proteins *Sodium Channels. J Neurosci 2003 Oct 1;23(26);8881-92
SCN4B protein, human  0   *Sodium Channels. J Neurosci 2003 Aug 20;23(20):7577-85
SCN1B protein, human  0   *Sodium Channels. J Biol Chem 1994 Mar 11;269(10):7571-8
para protein, Drosophila  0   *Sodium Channels *Drosophila Proteins. Cell 1989 Sep 22;58(6):1143-54
Scn4a protein, rat  0   *Muscle Proteins *Sodium Channels. Eur J Biochem 2002 Aug;269(16):3920-33
BNaC2 protein, mouse  0   *Nerve Tissue Proteins *Sodium Channels. Proc Natl Acad Sci U S A 1997 Feb 18;94(4):1459-64
sodium channel protein type 5 subunit alpha  0   *Sodium Channels Ion Channel Gating. Pflugers Arch 2001 Oct;443(1):18-30
NaChBac protein, bacteria  0   *Bacterial Proteins *Sodium Channels. Science 2001 Dec 14;294(5550):2372-5
scn8ab protein, zebrafish  0   *Sodium Channels *Zebrafish Proteins. DNA Cell Biol 2001 May;20(5):249-55
SCN3A protein, human  0   *Sodium Channels. J Mol Neurosci 1998 Feb;10(1):67-70
N-(2,6-dimethylphenyl)-2-pyrrolidinecarboxamide  0   *Pyrrolidines Sodium Channels/antagonists & inhibitors. J Med Chem 2000 Oct 5;43(20):3792-8
SUN N8075  0   *Aniline Compounds *Piperazines Sodium Channels/antagonists & inhibitors. J Med Chem 2000 Sep 7;43(18):3372-6
PcTX1 protein, Psalmopoeus cambridgei  0   *Spider Venoms Sodium Channels/antagonists & inhibitors. J Biol Chem 2000 Aug 18;275(33):2516-21
ACCN5 protein, human  0   *Sodium Channels. FEBS Lett 2000 Apr 14;471(2-3):205-10
sodium channel, voltage-gated, type I, alpha protein  0   *Nerve Tissue Proteins *Sodium Channels. Nat Genet 2000 Apr;24(4):343-5
N,N-(diphenyl)-4-ureido-5,7-dichloro-2-carboxyquinoline  0   *Phenylurea Compounds *Quinolines Sodium Channels/antagonists & inhibitors Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. J Pharmacol Exp Ther 2000 Jan;292(1):215-27
Scn7a protein, rat  0   *Nerve Tissue Proteins *Sodium Channels. J Neurochem 1999 Dec;73(6):2575-85
lysyl-isoleucyl-phenylalanyl-methionyl-lysine  0   *Oligopeptides Sodium Channels/antagonists & inhibitors. J Physiol (Lond) 1999 Jul 1;518(Pt 1):13-22
sodium channel, voltage-gated, type II, alpha 1 subunit  0   *Nerve Tissue Proteins *Sodium Channels Brain. J Mol Neurosci 1998 Dec;11(3):179-82
BIIR 561 CL  0   *Oxadiazoles Sodium Channels/antagonists & inhibitors Receptors, AMPA/antagonists & inhibitors. J Pharmacol Exp Ther 1999 Jun;289(3):1343-9
SCN2B protein, human  0   *Nerve Tissue Proteins *Sodium Channels Charcot-Marie-Tooth Disease. Eur J Hum Genet 1998 Nov-Dec;6(6):629-34
gamma-zeathionin proteins, Zea mays  0   *Plant Proteins *Antimicrobial Cationic Peptides Sodium Channels. FEBS Lett 1998 Dec 4;440(3):302-6
4030W92  0   *Pyrimidines Sodium Channels/antagonists & inhibitors. Br J Pharmacol 1998 Jul;124(5):953-63
Scn11a protein, rat  0   *Sodium Channels. Proc Natl Acad Sci U S A 1998 Jul 21;95(15):8963-8
1,3-bis(4-sec-butylphenyl)-4,5-dihydroimidazol-2-ylamine  0   *Imidazoles Sodium Channels/antagonists & inhibitors. J Med Chem 1998 Jul 30;41(16):3048-61
1,3-bis(4-sec-butylphenyl)tetrahydropyrimidin-2-ylideneamine  0   *Pyrimidines Sodium Channels/antagonists & inhibitors. J Med Chem 1998 Jul 30;41(16):3048-61
ACCN3 protein, human  0   *Sodium Channels. Biochem Biophys Res Commun 1998 Apr 17;245(2):589-93
rpk protein, Drosophila  0   *Sodium Channels *Drosophila Proteins. J Biol Chem 1998 Apr 17;273(16):9424-9
SCN1 protein, Polyorchis penicillatus  0   *Sodium Channels Ion Channel Gating. Biochem Biophys Res Comm 1998 Mar 27;244(3):772-80
dimethylaminoethyl p-butylaminobenzoate  0   *Benzoates Sodium Channels/antagonists & inhibitors. Biull Eksp Biol Med 1998 Jan:125(1):59-62
ASIC channel  0   *Nerve Tissue Proteins *Sodium Channels. J Biol Chem 1997 Aug 22;272(34):20975-8
BdNa1 protein, Bdelloura candida  0   *Sodium Channels *Helminth Proteins. Parasitology 1997 Sep;115( Pt 3):289-96
PomB protein, Vibrio  0   *Bacterial Proteins *Sodium Channels. J Bacteriol 1997 Aug;179(16):5104-10
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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