encyclopedia of medical concepts
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Dinoprostone

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Definition: The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.  do not confuse with DINOPROST; /biosyn /physiol permitted   
Pharmacological Action Oxytocics 		Other names Prostaglandin E2alpha; Prostaglandin E2; PGE2alpha; PGE2; alpha, Prostaglandin E2; alpha, PGE2; Gel, Prepidil; E2alpha, Prostaglandin; E2, Prostaglandin; E2 alpha, Prostaglandin; Prostenon; Prostaglandin E2 alpha; Prepidil Gel; PGE2 alphaDrugs* : PREPIDIL; PROSTIN E2; CERVIDIL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CAY 10580  0   *Pyrrolidinones Dinoprostone/*analogs & derivatives. Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12949-54
11,15-O-dimethylprostaglandin E2  0   Dinoprostone/*analogs & derivatives. Eur J Pharmacol 2009 Aug 15;616(1-3):64-7
prostaglandin E2 glyceryl ester  0   Dinoprostone/*analogs & derivatives. J Biol Chem 2001 Oct 5;276(40):36993-8
prostamide H2  0   Dinoprostone/*analogs & derivatives. J Lipid Res. 2005 Dec;46(12):2745-51
9-deoxy-9-chloro-15-deoxy-16-hydroxy-17,17-trimethylene-19,20-didehydroprostaglandin E2  0   Dinoprostone/*analogs & derivatives Receptors, Prostaglandin E/agonists. Br J Pharmacol 2004 Apr;141(7):1141-50
prostaglandin F2alpha ethanolamide  0   Dinoprostone/*analogs & derivatives. J Lipid Res. 2004 Apr;45(4):757-63
prostaglandin D2 ethanolamide  0   Dinoprostone/*analogs & derivatives. J Lipid Res. 2004 Apr;45(4):757-63
11-deoxy,16,16-dimethyl prostaglandin E(2)  0   Dinoprostone/*analogs & derivatives. Chem Res Toxicol. 2003 Jun;16(6):757-67
8-cyano-4-(4-methylpiperidino)-7-morpholinopyrido(3',2'-4,5)thieno(3,2-d)-1,2,3-triazine  0   *Thiophenes *Triazines Nitric Oxide/antagonists & inhibitors Dinoprostone/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4720-4
7-(N-4'-acetylphenylpiperazino)-8-cyano-4-chloropyrido(3',2'-4,5)thieno(3,2-d)-1,2,3-triazine  0   *Thiophenes *Triazines Nitric Oxide/antagonists & inhibitors Dinoprostone/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4720-4
ONO AE 248  0   Dinoprostone/analogs & derivatives. Arterioscler Thromb Vasc Biol 1999 Sep;19(9):2141-7
12-isoprostaglandin F(2alpha)  0   Dinoprostone/*analogs & derivatives. J Biol Chem 1997 Oct 24;272(43):27147-54
prostaglandin E2 ethanolamide  0   Dinoprostone/*analogs & derivatives. J Biol Chem 1997 Aug 22;272(34):21181-6
17-phenyltrinorprostaglandin E2  0   Dinoprostone/*analogs & derivatives. Brain Res 1994 Nov 14;663(2):287-92
16-methyl prostaglandin E2  39746-14-0 Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-16-methyl-9-oxo-, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives. Jpn J Pharmacol 1992;58 suppl 2:289P
17-(4-azidophenyl)-18,19,20-trinorprostaglandin E2  117625-46-4   Dinoprostone/*analogs & derivatives. Eicosanoids 1991;4(1):57
11-deoxyprostaglandin E2-1-alcohol  138898-70-1   Dinoprostone/*analogs & derivatives. Adv Prostaglandin Thromboxane Leukotriene Res 1991;21A:375
prostaglandin E2 azidophenacyl ester  129163-95-7   *Azides Dinoprostone/*analogs & derivatives. Febs Lett 1990;265(1-2):117
15-fluoro-15-deoxyprostaglandin E2  88736-32-7 Prosta-5,13-dien-1-oic acid, 15-fluoro-11-hydroxy-9-oxo-, (5Z,11alpha,13E)  Dinoprostone/*analogs & derivatives. Izv Akad Nauk SSR (Biol) 1989;(6):831
prostaglandin E2 methyl oxime  86659-90-7   Dinoprostone/*analogs & derivatives. Prostaglandins Leukot Esent Fatty Acids 1989;37(3):187
18-hydroxyprostaglandin E2  67355-95-7   Dinoprostone/*analogs & derivatives. Prostaglandins 1988;35(4):523
15-keto-13,14-dihydroprostaglandin E2-thyroglobulin conjugate  0   *Thyroglobulin Dinoprostone/*analogs & derivatives. Am J Physiol 1988;255(6 Pt 1):G723
19,20-dehydroprostaglandin E2  111219-93-3   Dinoprostone/*analogs & derivatives. Prostaglandins 1987;34(1):3
20-hydroxyprostaglandin E2  57930-95-7 Prosta-5,13-dien-1-oic acid, 11,15,20-trihydroxy-9-oxo-, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives. J Biol Chem 1986;261(20):9216
19-hydroxyprostaglandin E2  55123-68-7 Prosta-5,13-dien-1-oic acid, 11,15,19-trihydroxy-9-oxo-, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives. J Biol Chem 1986;261(20):9216
11-deoxy-11,12-methanoprostaglandin E2  102769-45-9   Dinoprostone/*analogs & derivatives. J Pharm Sci 1986;75(3):307
15-hydroperoxyprostaglandin E2  65380-05-4 Prosta-5,13-dien-1-oic acid, 15-hydroperoxy-11-hydroxy-9-oxo-, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives Prostaglandin Endoperoxides. J Biol Chem 1986;261(11):5023
HOE 260  58687-40-4   Dinoprostone/*analogs & derivatives. Biomed Biochim Acta 1984;43(8-9):S235
9-enol-prostaglandin E2 methyl ester trimethylsilyl ether  90293-03-1 Prosta-5,8,13-trien-1-oic acid, 9,11,15-tris((trimethylsilyl)oxy)-, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives. Biomed Mass Spectrom 1984;11(3):114
16-methyl-16-methoxyprostaglandin E2  61408-68-2   Dinoprostone/*analogs & derivatives. Prostaglandins 1984;27(4):583
prostaglandin E2 methyl ester  31753-17-0   Dinoprostone/*analogs & derivatives. Life Sci 1984;34(19):1861
FCE 20700  89648-76-0 Prost-5-en-13-yn-1-oic acid, 15-hydroxy-16-methyl-9-oxo-, methyl ester, (5Z,15S,16S)  Dinoprostone/*analogs & derivatives. Int J Tissue React 1983;5(4):349
trimoprostil  69900-72-7   Dinoprostone/*analogs & derivatives.
Pharma Action Anti-Ulcer Agents 		Arzneimittelforsch 1983;33(6):905; J Clin Invest 1983;72(1):295
viprostol  73621-92-8   Dinoprostone/*analogs & derivatives.
Pharma Action Antihypertensive Agents 		Prostaglandins 1982;23(2):185
15-deoxy-16-hydroxy-16-vinylprostaglandin E2  68666-91-1   Dinoprostone/*analogs & derivatives. Prostaglandins 1982;23(2):185
8,12-epi-prostaglandin E2  39265-67-3   Dinoprostone/*analogs & derivatives. J Reprod Fertil 1981;63(2):359
17,17-dimethylprostaglandin E2  80003-50-5 Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-17,17-dimethyl-9-oxo-, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives. J Reprod Fertil 1981;63(2):359
18,18,20-trimethylprostaglandin E2  80003-51-6 Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-18,18,20-trimethyl-9-oxo-, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives. J Reprod Fertil 1981;63(2):359
11-deoxy-11alpha-(2-hydroxyethylthio)-prostaglandin E2 methyl ester  74412-44-5 Prosta-5,13-dien-1-oic acid, 15-hydroxy-11-((2-hydroxyethyl)thio)-9-oxo-, methyl ester, (5Z,11alpha,13E,15S)  Dinoprostone/*analogs & derivatives. Prostaglandins 1981;21(3):457
16-methyl-13,14-didehydroprostaglandin E2  0   Dinoprostone/*analogs & derivatives. Prostaglandins Med 1979;2(6):459
20-methyl-13,14-didehydroprostaglandin E2  0   Dinoprostone/*analogs & derivatives. Prostaglandins Med 1979;2(6):459
13,14-didehydroprostaglandin E2  0   Dinoprostone/*analogs & derivatives. Prostaglandins Med 1979;2(6):459
16-methyl-20-methoxy-PGE2  61218-31-3   Dinoprostone/*analogs & derivatives. Arch Int Pharmacodyn Ther 1980;244(1):157
15-ketoprostaglandin E2  26441-05-4   Dinoprostone/*analogs & derivatives. Eur J Obstet Gynaecol Reprod Biol 1980;10(5):297
13,14-dihydro-16-phenyl-omega-tetranorprostaglandin E2  63814-25-5   Dinoprostone/*analogs & derivatives. Prostaglandins 1980;20(3):515
13,14-dihydroprostaglandin E2  363-22-4 prost-5-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,15S)  Dinoprostone/*analogs & derivatives. Prostaglandins 1980;19(3):391
11-deoxy-15-keto-13,14-dihydro-11 beta,16-cycloprostaglandin E2  74158-09-1 5-Heptenoic acid, 7-(4-butyloctahydro-2,5-dioxo-1H-inden-1-yl)  Dinoprostone/*analogs & derivatives. Adv Prostaglandin Thromboxane Res 1980;6:181
15-keto-13,14-dihydroprostaglandin E2  363-23-5 prost-5-en-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11 alpha)  Dinoprostone/*analogs & derivatives. Adv Prostaglandin Thromboxane Res 1980;6:181; Adv Prostaglandin Thromboxane Res 1980;6:585
N-acetylprostaglandin E2 carboxamide  52533-44-5 (5Z,11 alpha,13E,15S)-N-acetyl-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-amide  Dinoprostone/*analogs & derivatives. Prostaglandins 1979;18(5):773; Prostaglandins 1979;18(5):779
20-isopropylidene prostaglandin E2  59982-03-5 5-Heptenoic acid, 7-(3-hydroxy-2-(3-hydroxy-9-methyl-1,8-decadienyl)-5-oxocyclopentyl)-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha))  Dinoprostone/*analogs & derivatives. Adv Prostaglandin Thromboxane Res 1980;7;985
1a,1b-dihomoprostaglandin E2  26198-80-1 (1R-(1 alpha(Z),2 beta(1E,3S*),3 alpha))-9-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-7- nonenoic acid  Dinoprostone/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 10(3):443;1975; Prostaglandins 18(4):617;1979
sulprostone  60325-46-4   Dinoprostone/*analogs & derivatives.
Pharma Action Abortifacient Agents, Nonsteroidal ; Menstruation-Inducing Agents 		Contraception 16(4):377;1977; Contraception 18(6):635;1978; Contraception 19(1):29;1979; Lancet 1980;1(8159):90; Med Klin 73(37):1281;1978; Prostaglandins 15(1):171;1978; Prostaglandins 1979;18(2):292; Prostaglandins 1979;18(3):479
8-isoprostaglandin E2  27415-25-4   *Isoprostanes Dinoprostone/*analogs & derivatives Isomerism.
Pharma Action Vasoconstrictor Agents 		Prostaglandins 17(2):259;1979

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