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Thiorphan

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Definition: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.     
Pharmacological Action Protease Inhibitors 		Other names Thiorphan, (S)-Isomer; Thiorphan, (R)-Isomer; (3-Mercapto-2-benzylpropionyl)glycine; Tiorphan
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
dexecadotril  0   Thiorphan/*analogs & derivatives. Mini Rev Med Chem 2002 Jun;2(3):209-17
S-acetylthiorphan  124735-06-4   Thiorphan/*analogs & derivatives. Eur J Pharmacol 1993 Oct 19;243(2):129-34
retrothiorphan  82154-09-4 Propanoic acid, 3-((1-(mercaptomethyl)-2-phenylethyl)amino)-3-oxo-, (+-)  Thiorphan/*analogs & derivatives Neprilysin/antagonists & inhibitors. J Biol Chem 1992 Feb 5;267(4):2138-41
leucine thiorphan  80970-04-3   Thiorphan/*analogs & derivatives. J Appl Physiol 1987;63(4):1401
GB 52  123902-39-6   Thiorphan/*analogs & derivatives. Neuropharmacology 1986;25(8):819
acetorphan  81110-73-8 Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (+-)  Thiorphan/*analogs & derivatives Neprilysin/antagonists & inhibitors.
Pharma Action Antidiarrheals ; Protease Inhibitors 		J Pharmacol Exp Ther 1986;237(3):937
ES 52  93783-79-0 ES 52  Thiorphan/*analogs & derivatives. Life Sci 1983;33 suppl 1:545
azidothiorphan  83960-29-6 Glycine, N-(3-(4-azidophenyl)-2-(mercaptomethyl)-1-oxopropyl)-, (+-)  *Azides Thiorphan/*analogs & derivatives. Life Sci 11982;31(16-117):1749

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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